Bizarre giant cells in human angiosarcoma exhibit chemoresistance and contribute to poor survival outcomes

Tan, Grace Fangmin; Goh, Shane; Lim, Abner Herbert; Liu, Wei; Lee, Jing Yi; Rajasegaran, Vikneswari; Sam, Xin Xiu; Tay, Timothy Kwang Yong; Selvarajan, Sathiyamoorthy; Ng, Cedric Chuan‐Young; Teh, Bin Tean; Chan, Jason Yongsheng

doi:10.1111/cas.14726

Cited by 10 publications

(8 citation statements)

References 32 publications

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“…STC1 is one of the downstream genes of HIF‐1α, and the presence of HRE (hypoxia‐response element) in the promoter region of STC1 has been confirmed in previous studies 12 . It also has been reported by many literatures that STC1 expression could be upregulated by HIF‐1α in certain human tumors, 11,20–22 and is also believed to be involved in tumor development and chemotherapy resistance 23,24 …”

Section: Discussionmentioning

confidence: 53%

“…12 It also has been reported by many literatures that STC1 expression could be upregulated by HIF-1α in certain human tumors, 11,[20][21][22] and is also believed to be involved in tumor development and chemotherapy resistance. 23,24 However, as a transcription factor, HIF-1α could regulate a series of downstream genes, recently researchers found that HIF-1α drives gemcitabine resistance in pancreatic cancer by modulating the transcription of IL37. 25 And STC1 transcription is not only regulated by HIF-1α, research has proved that STC1 transcription could be promoted by DROSHA to maintain the stemness of breast cancer cells.…”

Section: Discussionmentioning

confidence: 99%

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HIF‐1α‐regulated stanniocalcin‐1 mediates gemcitabine resistance in pancreatic ductal adenocarcinoma via PI3K/AKT signaling pathway

Zhao

Qiu

et al. 2022

Molecular Carcinogenesis

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Pancreatic ductal adenocarcinoma (PDAC) has a poor response to the first‐line chemotherapy drug gemcitabine. We previously identified stanniocalcin‐1 as a gemcitabine‐resistant‐related gene, but its specific role and function in pancreatic cancer remain unclear. RT‐qPCR and Western blot were used to evaluate differential protein and mRNA expressions. The biological functions of genes were determined using proliferation and drug‐resistance experiments. Subcutaneous tumorigenesis experiment was performed on nude mice. Prognostic analysis was performed using public databases and our clinical data. We found HIF‐1α‐regulated STC1 expression mediated chemoresistance in pancreatic cancer. Deeper, we explored the action mechanism of STC1 and identified PI3K/AKT as the downstream signaling pathway of STC1. Furthermore, we analyzed clinical data and found that STC1 expression was related to the prognosis of gemcitabine‐treated patients after surgery. In general, we proved the HIF‐1α/STC1/PI3K‐AKT axis participated in PDAC progression and chemoresistance, and STC1 may serve as a potential prognostic factor and therapeutic target for PDAC treatment.

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Section: Discussionmentioning

confidence: 53%

Section: Discussionmentioning

confidence: 99%

HIF‐1α‐regulated stanniocalcin‐1 mediates gemcitabine resistance in pancreatic ductal adenocarcinoma via PI3K/AKT signaling pathway

Zhao

Qiu

et al. 2022

Molecular Carcinogenesis

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“…The Di-Electro-Phoretic Array (DEPArray) system is a microchip-based digital sorter combining precise microfluidics and microelectronics in a highly automated platform, allowing the isolation of single cells for downstream genomic amplification and sequencing [ 145 ]. Its application, though limited in terms of scalability and high costs involved, enables the recovery of individual rare cells of interest from heterogeneous samples for detailed analysis [ 146 ]. A more cost-efficient strategy for single cell genomic analysis is to use a targeted sequencing approach for the detection of specific gene mutations and clonal structure within the tumor, achievable using the Tapestri system [ 147 , 148 , 149 ].…”

Section: Emergence Of Single-cell Technologiesmentioning

confidence: 99%

The Multi-Dimensional Biomarker Landscape in Cancer Immunotherapy

Lee

Kannan

Lim

et al. 2022

IJMS

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The field of immuno-oncology is now at the forefront of cancer care and is rapidly evolving. The immune checkpoint blockade has been demonstrated to restore antitumor responses in several cancer types. However, durable responses can be observed only in a subset of patients, highlighting the importance of investigating the tumor microenvironment (TME) and cellular heterogeneity to define the phenotypes that contribute to resistance as opposed to those that confer susceptibility to immune surveillance and immunotherapy. In this review, we summarize how some of the most widely used conventional technologies and biomarkers may be useful for the purpose of predicting immunotherapy outcomes in patients, and discuss their shortcomings. We also provide an overview of how emerging single-cell spatial omics may be applied to further advance our understanding of the interactions within the TME, and how these technologies help to deliver important new insights into biomarker discovery to improve the prediction of patient response.

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“…In the sample of angiosarcoma containing giant cells, the COL11A1 gene was overexpressed with up-regulation of immune-related metabolic stress and metastasis/matrix remodeling pathways. 73 COL11A1 was overexpressed in bladder cancer and was found to be associated with tumor invasion and metastasis. 74,75 Whole transcriptome analysis of 36 fresh osteosarcoma samples revealed that COL11A1 was involved in the development of osteosarcoma.…”

Section: Other Cancermentioning

confidence: 99%

Collagen XI alpha 1 chain, a potential therapeutic target for cancer

et al. 2021

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Cancer has become the third leading cause of death worldwide, with approximately 1 742 650 confirmed cancer cases and 606 880 cancer deaths in the United States in 2019. 1 Although clinical classification, staging, and treatment guidelines for various cancers are constantly being updated, improving the long-term prognosis in cancer patients remains difficult. It is very important to explore effective cancer treatment strategies. In the past, scientists have only studied the biological mechanisms in a single tumor cell, while ignoring the relationship between cancer cells and the surrounding tissues. More and more recent studies have focused on the tumor microenvironment, proving that it is involved in the progression of cancer.Extracellular matrix (ECM) is a non-cellular component that exists in all tissues and organs. There are two types of

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Bizarre giant cells in human angiosarcoma exhibit chemoresistance and contribute to poor survival outcomes

Abstract: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Cited by 10 publications

References 32 publications

HIF‐1α‐regulated stanniocalcin‐1 mediates gemcitabine resistance in pancreatic ductal adenocarcinoma via PI3K/AKT signaling pathway

HIF‐1α‐regulated stanniocalcin‐1 mediates gemcitabine resistance in pancreatic ductal adenocarcinoma via PI3K/AKT signaling pathway

The Multi-Dimensional Biomarker Landscape in Cancer Immunotherapy

Collagen XI alpha 1 chain, a potential therapeutic target for cancer

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