BK Nephropathy as a Cause of Renal Dysfunction in an ABO-incompatible Liver Transplant Patient

Lai, Christina; Bleasel, J. F.; McGrath, J.; Majumdar, Avik; Kirwan, Paul; Anderson, Lyndal; Strasser, Simone I.; Gracey, David

doi:10.1097/tp.0000000000003044

Cited by 3 publications

(6 citation statements)

References 5 publications

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“…Diagnosis of biopsy-proven BK nephropathy (Figs. 1 and 2 ) occurred twenty-two months post-transplant with 754 976 copies/mL, which was previously reported in Transplantation [ 9 ]. At diagnosis, creatinine was 297 mg/dL with an eGFR of 19 mL/min/1.73m 2 ; and the haemoglobin was 73 g/L.…”

Section: Introductionsupporting

confidence: 67%

BK viraemia as a cause of anaemia in after ABO-incompatible liver transplant: a case report

McMullen,

Khoo,

Anderson

et al. 2023

BMC Infect Dis

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Background While anaemia following liver transplant is common, anaemia in the context of BK viraemia is not a commonly recognised phenomenon. Case presentation We present the case of 59-year old gentleman with severe anaemia in the context of BK viraemia and nephropathy following ABO incompatible liver transplant. Severity of anaemia appeared to correlate with high titres of BK virus in the serum. Bone marrow biopsy revealed hypocellular marrow with normal cytogenetics. Anaemia improved with treatment with cidofovir, intravenous immunoglobulin, reduction in immunosuppression and erythropoietin stimulating agent. Conclusion To our knowledge, this is the first case of anaemia post liver transplant contributed to by BK viraemia.

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Section: Introductionsupporting

confidence: 67%

BK viraemia as a cause of anaemia in after ABO-incompatible liver transplant: a case report

McMullen,

Khoo,

Anderson

et al. 2023

BMC Infect Dis

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“…Seven out of these eleven patients had diabetes mellitus that was being treated with medications. Our literature search revealed 24 previous reports of biopsy‐proven native BKV nephropathy in NRSOT patients bringing the total to 28 12‐35 Table 3 summarizes the renal outcome in these patients categorized by type of solid organ transplant. It can be seen that a majority of NRSOT patients with biopsy‐proven native kidney BKV nephropathy were reported to have developed CKD or ESRD.…”

Section: Resultsmentioning

confidence: 99%

“…Native kidney BKV associated disease in non‐renal solid organ transplant (NRSOT) recipients has been described in case reports and series over the years, but it has not been systematically studied 12‐35 . BKV nephropathy in the NRSOT recipient has the potential to lead to chronic kidney disease (CKD) or end‐stage renal disease (ESRD) with associated morbidity and mortality 36‐38 .…”

Section: Introductionmentioning

confidence: 99%

BK virus nephropathy in non‐renal solid organ transplant recipients: Are we looking hard enough?

Mallavarapu

Sanoff

Howell

et al. 2021

Clinical Transplantation

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We retrospectively examined the clinical characteristics, pathological features, and outcomes of BK viremia and nephropathy in a population of non‐renal solid organ transplant patients (NRSOT) referred for outpatient nephrology consultation over a period of 5 years. In the entire cohort of liver, heart, and lung transplant recipients referred to this clinic, 14% percent were found to have BK viremia with a median peak serum BK viral load of 35 500 copies/ml (range 250 to 21 100 000 copies/ml). BK viremia resolved in six of the seventeen patients (35%). Four out of five patients biopsied showed BK virus (BKV) nephropathy. Eleven out of seventeen patients with BK viremia developed advanced (stage 4 or 5) chronic kidney disease. Four patients developed rejection of their solid organ transplant within the first year post detection of BK viremia after immunosuppression reduction. We conclude that a multi‐center study is required to evaluate whether implementation of a systematic BK screening program would be effective in early detection and management of this problem in the NRSOT population.

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“…Lai et al. 6 described a 59-year-old male who had a liver transplant 2 years earlier and presented acutely with biopsy-proven cytomegalovirus colitis, acute kidney injury (serum creatinine of 280 μmol/l), biopsy-proven BKVN, and 754,976 copies per milliliter of BK virus in his serum. 6 Zeng et al.…”

Section: Discussionmentioning

confidence: 99%

“… 6 described a 59-year-old male who had a liver transplant 2 years earlier and presented acutely with biopsy-proven cytomegalovirus colitis, acute kidney injury (serum creatinine of 280 μmol/l), biopsy-proven BKVN, and 754,976 copies per milliliter of BK virus in his serum. 6 Zeng et al. 7 described a 59-year-old man who had a liver transplant 7 years earlier who had an increase in creatinine from 90 μmol/l to 165 μmol/l over 6 months which was initially ascribed to tacrolimus toxicity.…”

Section: Discussionmentioning

confidence: 99%

BK Virus Nephropathy in the Native Kidney of a Liver Transplant Recipient

Sekulic

Sloan

Guo

et al. 2021

Kidney International Reports

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BK Nephropathy as a Cause of Renal Dysfunction in an ABO-incompatible Liver Transplant Patient

Cited by 3 publications

References 5 publications

BK viraemia as a cause of anaemia in after ABO-incompatible liver transplant: a case report

BK viraemia as a cause of anaemia in after ABO-incompatible liver transplant: a case report

BK virus nephropathy in non‐renal solid organ transplant recipients: Are we looking hard enough?

BK Virus Nephropathy in the Native Kidney of a Liver Transplant Recipient

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