BK polyoma virus nephropathy in the native kidney

Sharma, Smriti; Nickeleit, Volker; Herlitz, Leal; González, Anne Koehne de; Stokes, Michael B.; Singh, Harsharan K.; Markowitz, Glen S.; D’Agati, Vivette D.

doi:10.1093/ndt/gfs537

Cited by 58 publications

(61 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a report of eight cases of BKVN in the native kidney by Sharma et al (11), the median duration of immunosuppression was 3.15 years (1-10 years). Six cases had a hematological malignancy, three cases were on chemotherapy due to bone marrow transplantation, three cases were on chemotherapy due to hematological malignancy, one case was on immunosuppressive therapy due to cystic fibrosis and one case was on immunosuppressive therapy due to diabetes and tuberculosis.…”

Section: Resultsmentioning

confidence: 99%

“…immunosuppression. BKVN of the native kidney has been reported to occur after transplantation of solid organs such as the liver, pancreas, heart and lungs and after bone marrow transplantation (11). Ducharme et al (13) reported that prolonged time after heart transplantation, low glomerulofiltration rates, prior EBV infection and use of sirolimus were risk factors of BK in heart transplant recipients.…”

Section: Discussionmentioning

confidence: 99%

“…Reactivation of BKV in these immunosuppressed patients is similar to that observed after renal transplantation. Sharma et al have reported eight cases of BKVN in the native kidney presenting with acute renal failure (11).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of Renal Biopsies for BK Virus Nephropathy in Non-Renal Transplant Immunosuppressed Patients

Merhametsiz¹,

Yıldırım²,

Oğuz³

et al. 2016

Turk Neph Dial Transpl

View full text Add to dashboard Cite

OBJeCtIVe: Although BK virus nephropathy (BKVN) has mostly been reported to occur in transplanted kidneys, there has been a gradual increase in cases of BKVN in the native kidney. This study was directed towards investigating the incidence of BKVN in patients undergoing renal biopsy due to acute kidney injury (AKI) who were also immunosuppressed due to a condition other than organ transplantation. MAterIAl and MethOds:Out of the 1223 patients undergoing renal biopsy for various conditions between January 2001 and January 2013, 52 patients who underwent a biopsy for AKI and were immunosuppressed at the time of the biopsy were included into the study. After renal biopsies of all patients were reevaluated, all biopsy specimens were exposed to immunohistochemical staining for SV40 antibody. results:Of the 52 patients, 29 had primary glomerulonephritis, 18 had secondary glomerulonephritis and 5 had a malignancy. All patients except one case of acute lymphoblastic leukemia and one case of non-Hodgkin lymphoma were immunosuppressed due to immunosuppressive therapy. None of the patients had any signs of BKVN on immunohistochemical staining of renal biopsy specimens.COnClusIOn: Failure to detect BKVN in this study may be because BKV causes gradual impairment of renal functions and the sample did not include patients frequently observed to have BKVN in the native kidney.keY wOrds: Acute kidney injury, BK virus nephropathy, Immunosuppression, Renal biopsy, Renal transplantation, SV40 antibody Öz AMAÇ: BK virüs nefropatisi (BKVN) çoğunluğu böbrek nakli olgularında tanımlansa da, öz böbreklerde de giderek artan oranda BKVN olguları tanımlanmaktadır. Çalışmada, akut böbrek yetmezliği nedeniyle böbrek biyopsisi yapılan organ nakli dışında bir nedene bağlı immünsüpresif hastaların renal biyopsi örneklerinde BKVN sıklığını araştırmayı amaçladık. GereÇ ve YÖnteMler:Ocak 2001-Ocak 2013 tarihleri arasında çeşitli nedenlerle böbrek biyopsisi yapılmış 1223 hastadan akut böbrek hasarı nedeniyle biyopsi yapılmış ve biyopsi esnasında immünsüpresif olup çalışmaya uygun olan 52 hasta çalışmaya dahil edildi. Çalışmaya alınan hastaların böbrek biyopsileri tekrar değerlendirilerek ışık mikroskopisinde BKV'ye ait olabilecek değişiklikler arandıktan sonra tüm biyopsi materyallerine SV40 immünhistokimyasal antikor boyaması yapıldı.BulGulAr: Olguların tanısal dağılımı şu şekildeydi; 29 hasta primer glomerülonefrit (GN), 18 hasta sekonder GN ve 5 hasta malignite. Hastaların ikisi (ALL ve NHL olguları) hariç hepsi immünsüpresif tedavi nedeniyle immünsüpresiftiler. Böbrek biyopsilerinde yapılan immün histokimyasal boyamada 52 olgunun hiçbirinde BKVN'ye ait bulguya rastlanmadı ve tüm olgularda SV40 negatif saptandı.sOnuÇ: Sonuç olarak çalışmamızda, akut böbrek hasarı nedeniyle böbrek biyopsisi yapılmış olgularda BKVN'yi saptayamamış olmamız, BKVN'nin böbrek fonksiyonlarında yavaş seyirli bir bozulmaya sebep olmasından veya bu çalışmanın BKV'nin öz böbrek nefropatisinin daha çok izlendiği hastaları içermemesinden kaynaklanmış olabilir.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of Renal Biopsies for BK Virus Nephropathy in Non-Renal Transplant Immunosuppressed Patients

Merhametsiz¹,

Yıldırım²,

Oğuz³

et al. 2016

Turk Neph Dial Transpl

View full text Add to dashboard Cite

show abstract

“…3 The virus is prevalent in humans, with more than 80% of the population estimated to be seropositive up to early adolescence. [4][5][6] Under the pressures of immune responses, BK polyomavirus infection is suppressed but not eradicated, and latent forms of the disease can evolve. Therefore, BK polyomavirus may be reactivated when the immune system is suppressed.…”

Section: Introductionmentioning

confidence: 99%

“…7 Virus reactivation is a main complication after renal transplant, inducing BK virus-associated nephropathy (BKVAN). [4][5][6]8 BK virus-associated nephropathy is characterized by inflammatory interstitial nephropathy. 9 It appears that immunologic parameters may be involved in the pathogenesis of BKVAN.…”

Section: Introductionmentioning

confidence: 99%

Untitled

Kariminik

Yaghobi

Dabiri³

2018

Exp Clin Transplant

View full text Add to dashboard Cite

Objectives: It has been hypothesized that BK polyomavirus infection leads to nephropathy in kidney transplant patients via various plausible mechanisms, such as stimulation of chemokines. The CXCL11 gene may also play a role in BK polyomavirusassociated nephropathy. Our aim was to compare expression levels of CXCL11 in BK polyomavirusinfected versus noninfected kidney transplant patients with nephropathy and healthy controls. Materials and Methods: We performed a cross-sectional study of 58 kidney transplant patients with the risk of BK polyomavirus infection; these patients were subgrouped as BK polyomavirus-infected (23 patients) and noninfected (35 patients). We also enrolled 30 healthy patients as controls in this study. The BK polyomavirus genome load was evaluated using a quantitative real-time polymerase chain reaction protocol in kidney transplant patients. We analyzed CXCL11 gene expression and protein levels using inhouse SYBR green real-time polymerase chain reaction and enzyme-linked immunosorbent assay protocols. Results: The expression level of the CXCL11 gene was increased 22.37 ± 23.1-fold in BK polyomavirusinfected kidney recipients and 12 ± 24-fold in noninfected patients versus that shown in controls. Conclusion: From these results, we concluded that BK polyomavirus infection can induce CXCL11 gene expression in kidney transplant patients compared with that shown in patients without BK infection and healthy patients. However, further studies are needed to determine the accurate counteraction between BK polyomavirus infection and CXCL11 in kidney transplant patients.

show abstract

Native kidney BK nephropathy: A case report

Zein

Price

Chen

et al. 2019

Clinical Case Reports

View full text Add to dashboard Cite

Key Clinical Message BK virus nephropathy ( BKN ) is uncommonly reported in native kidneys; mostly reported in bone marrow transplant patients. This case report represents an interesting clinical scenario of biopsy‐proven BKN in native kidneys, in the presence of more than one million copies/ mL of BK virus in serum.

show abstract

BK polyoma virus nephropathy in the native kidney

Abstract: A high level of suspicion in immunocompromised patients is needed to diagnose PVN in an early stage that may respond more favorably to antiviral therapy.

Cited by 58 publications

References 52 publications

Evaluation of Renal Biopsies for BK Virus Nephropathy in Non-Renal Transplant Immunosuppressed Patients

Evaluation of Renal Biopsies for BK Virus Nephropathy in Non-Renal Transplant Immunosuppressed Patients

Untitled

Native kidney BK nephropathy: A case report

Contact Info

Product

Resources

About