BK virus replication in renal transplant recipients: Analysis of potential risk factors may contribute in reactivation

Shenagari, Mohammad; Monfared, Ali Shabestani; Eghtedari, Hadise; Pourkazemi, Aydin; Hasandokht, Tolou; Khosravi, Masoud; Asharfkhani, Babak

doi:10.1016/j.jcv.2017.09.004

Cited by 21 publications

(16 citation statements)

References 30 publications

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“…This percentage was relatively higher than the prevalence stated in previous studies including Hirsch et al (13%), Awadalla et al (9%), and Masutani et al (10%). On the other hand, Borni‐Duval et al and Shenagari et al reported a BKV prevalence of up to 20%. These differences in prevalence can be explained by center‐to‐center variation in immunosuppressive protocols as the immune status of the renal transplant recipient plays a crucial role in BKV.…”

Section: Discussionmentioning

confidence: 97%

Impact of human leukocyte antigen and calculated panel reactive antibody on BK viremia in kidney transplant recipients: A single‐center experience and literature review

El‐Husseini

Hassan

Yaseen

et al. 2019

Transplant Infectious Dis

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Background The aim of this retrospective analysis was to investigate the effect of human leukocyte antigen (HLA) and calculated panel reactive antibody (cPRA) on BK virus activation as evidenced by BK viremia (BKV). Patients and Methods At our institution, 649 kidney transplant patients were screened for BKV from 2009 to 2017. Patients were considered to have BKV if they had >10 000 copies/mL of BK DNA in their blood. Donor and recipient HLA and cPRA, demographic, clinical and laboratory data, as well as immunosuppressive medications were collected. Results We identified 122 BK positive and 527 BK negative patients. Only 25% of the patients had cPRA of 20% or more, and 64% had more than three HLA‐A, ‐B, and ‐DR mismatches. In both univariate and multivariate analyses, male gender, age, and maintenance of steroid therapy significantly increased the risk of BKV (P = 0.005, 0.005 and <0.001, respectively). The degree of cPRA and the individual HLA allele and HLA allele matching did not significantly affect BKV. Conclusion Neither the degree of HLA mismatching nor cPRA appears to affect BKV. Moreover, no specific HLA allele, HLA allele matching, or cPRA were associated with BKV.

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Section: Discussionmentioning

confidence: 97%

Impact of human leukocyte antigen and calculated panel reactive antibody on BK viremia in kidney transplant recipients: A single‐center experience and literature review

El‐Husseini

Hassan

Yaseen

et al. 2019

Transplant Infectious Dis

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“…Allograft dysfunction occurs due to leakage of urine from injured tubules into the surrounding interstitium and peritubular capillaries . Though BK nephropathy occurs infrequently in patients following other solid organ transplant or bone marrow transplant, it is much more common after kidney transplantation …”

Section: Introductionmentioning

confidence: 99%

“…In addition to the overall degree of immunosuppression, certain agents have been associated with higher risk of BK nephropathy in studies, including rabbit antithymocyte globulin induction . and maintenance immunosuppression with tacrolimus and mycophenolate . Corticosteroid maintenance therapy has also been associated with increased risk of BK viremia or nephropathy in limited studies .…”

Section: Introductionmentioning

confidence: 99%

“…6 Though BK nephropathy occurs infrequently in patients following other solid organ transplant or bone marrow transplant, it is much more common after kidney transplantation. 1,7 Coincident with the adoption of increasingly aggressive immunosuppressive regimens, the incidence and prevalence of BK nephropathy has increased in recent years compared to when the condition was first described in the mid-1990s. 2 Higher-potency immunosuppression regimens are thought to create a permissive environment for BK viral replication and represent an important risk factor for viral reactivation.…”

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confidence: 99%

“…8,9 and maintenance immunosuppression with tacrolimus and mycophenolate. 1,2,7,9,10 Corticosteroid maintenance therapy has also been associated with increased risk of BK viremia or nephropathy in limited studies. 2,[8][9][10] Management of BK nephropathy predominantly involves reduction of immunosuppression as anti-BK effective therapies are limited.…”

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confidence: 99%

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Kidney transplant recipients with polycystic kidney disease have a lower risk of post‐transplant BK infection than those with end‐stage renal disease due to other causes

Plafkin

Singh

Astor

et al. 2018

Transplant Infectious Dis

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Longitudinal study of human polyomaviruses viruria in kidney transplant recipients

Dolci,

Colico,

Ambrogi

et al. 2024

Clin Exp Med

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Introduction Immunosuppression after kidney transplantation (KTx) exposes recipients to Human Polyomaviruses (HPyVs) infections, whose natural history is still misunderstood. Methods Allograft biopsies, and urine from 58 donor-recipient pairs were collected before KTx (T0) and 1 (T1), 15 (T2), 30 (T3), 60 (T4), 90 (T5), 180 (T6), 270 (T7), 360 (T8), and 540 (T9) days after transplant. Specimens were tested for JC (JCPyV) and BK (BKPyV), by quantitative Real-Time PCR. The course of post-KTx HPyVs viruria, and the association between JCPyV viruria in recipients and donors, were evaluated. Results HPyVs were detected in 3/58 (5.2%) allograft biopsies. HPyVs viruria was present in 29/58 (50%) donors and 41/58 (70.7%) recipients. JCPyV DNA was detected in 26/58 (44.8%) donors and 25/58 recipients (43.1%), 19 of whom received kidney from JCPyV positive donor, whereas BKPyV genome was detected in 3 (5.2%) donors and 22 (37.9%) recipients. The median time of JCPyV, and BKPyV first episode of replication was 1, and 171 days post KTx, respectively. At T0, JCPyV viruria of donors was associated with increased risk of JCPyV replication post-KTx; recipients with JCPyV positive donors showed lower risk of BKPyV replication post-KTx. Conclusions The results suggested that JCPyV may be transmitted by allograft, and that its replication post KTx might prevent BKPyV reactivation. Future investigation regarding correlation between chronic exposure to immunosuppressive agents and HPyVs urinary replication are warranted.

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BK virus replication in renal transplant recipients: Analysis of potential risk factors may contribute in reactivation

Cited by 21 publications

References 30 publications

Impact of human leukocyte antigen and calculated panel reactive antibody on BK viremia in kidney transplant recipients: A single‐center experience and literature review

Impact of human leukocyte antigen and calculated panel reactive antibody on BK viremia in kidney transplant recipients: A single‐center experience and literature review

Kidney transplant recipients with polycystic kidney disease have a lower risk of post‐transplant BK infection than those with end‐stage renal disease due to other causes

Longitudinal study of human polyomaviruses viruria in kidney transplant recipients

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