Black Mn-containing layered double hydroxide coated magnesium alloy for osteosarcoma therapy, bacteria killing, and bone regeneration

Recent Advances in the Development and Antimicrobial Applications of Metal–Phenolic Networks

“…Bone defects caused by trauma, fracture, osteomyelitis, or bone tumor resection are often accompanied by infection, leading to poor clinical prognosis. [162][163][164][165] MPNs combine the specific functions of metal ions and polyphenol ligands, exhibiting unique advantages that are tailored to the desired properties of orthopedic biomaterials. Natural polyphenols contain plenty [159] Copyright 2021, Elsevier.…”

“…Bone defects caused by trauma, fracture, osteomyelitis, or bone tumor resection are often accompanied by infection, leading to poor clinical prognosis. [ 162–165 ] MPNs combine the specific functions of metal ions and polyphenol ligands, exhibiting unique advantages that are tailored to the desired properties of orthopedic biomaterials. Natural polyphenols contain plenty phenolic hydroxyl groups providing tissue adhesive, antioxidant, and anti‐inflammatory properties in addition to metal ions chelating ability, and some specific polyphenols have antimicrobial properties themselves.…”

Layered double hydroxide-based nanomaterials for biomedical applications

“…Zhang et al developed MgMn-LDH-modified Mg alloy implants for bone regeneration, osteosarcoma therapy and bacteria killing. 447 The LDH film not only enhanced the corrosion resistance and osteogenic differentiation of Mg alloy implants, but also endowed them with superior chemodynamic/photothermal effects due to the CDT-mediated ROS generation and NIR absorption abilities of black MgMn-LDH. In vitro and in vivo assays fully demonstrated the excellent antitumor and bone regeneration properties as well as bactericidal activity of LDH-modified Mg alloy implants.…”

Progress in bioactive surface coatings on biodegradable Mg alloys: A critical review towards clinical translation

“…However, the drop in contact angle to 60° after 48 h of immersion indicated gradual deterioration of LDH film with prolonged immersion. Recently, Zhang et al [ 228 ] fabricated a black Mg–Mn(Ⅱ)-Mn(Ⅲ) LDH coating on AZ31 Mg alloy to evaluate the biodegradation, osteosarcoma destruction, anti-bacteria, and bone defect regeneration abilities. Due to the unique properties of the constructed black LDH film, including near-infrared optical absorption and reactive oxygen species (ROS) generation in the tumor-specific microenvironment, tumor cells and tissue were significantly eliminated.…”