Black phosphorous nanosheet: A novel immune-potentiating nanoadjuvant for near-infrared-improved immunotherapy

Li, Wenhao; Wu, Junjun; Wu, Lie; Zhang, Bo‐Dou; Hu, Hong‐Guo; Zhao, Lang; Li, Zhibin; Yu, Xue‐Feng; Li, Yanmei

doi:10.1016/j.biomaterials.2021.120788

Cited by 53 publications

(40 citation statements)

References 53 publications

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“…However, ~ 80% patients were suffered from tumor recrudescence after thermotherapy [ 45 ]. Nanomaterials have recently been reported to active the immunity system and cause specific immune effects alongside the physical ablation by heat, suggesting their potential reduction on tumor recrudescence [ 46 , 47 ]. Based on this, comprehensive investigations on the specific immune responses of nanomaterials on the liver cancer should be conducted.…”

Section: Resultsmentioning

confidence: 99%

Black phosphorus-Au-thiosugar nanosheets mediated photothermal induced anti-tumor effect enhancement by promoting infiltration of NK cells in hepatocellular carcinoma

et al. 2022

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Background Hepatocellular carcinoma (HCC) is a heterogeneous cancer required combination therapy, such as photothermal therapy and chemotherapy. In recent years, cancer immunotherapies are rapidly evolving and are some of the most promising avenues to approach malignancies. Thus, the combination of the traditional therapies and immunotherapy in one platform may improve the efficacy for HCC treatment. Results In this work, we have prepared a black phosphorus (BP)-Au-thiosugar nanosheets (BATNS), in which Au-thiosugar coating and functionalization improved the stability of both black phosphorus nanosheets (BPNS) and gold ions in different simulated physiological environments. The compression of the BATNS band gap can convert more photon energy to heat generation compared with BPNS, resulting in higher photothermal conversion efficiency. The in vitro and in vivo results also revealed a stronger reduction on the hepatocellular carcinoma of mice and prolonged survival of disease models compared with BPNS. More importantly, BATNS showed an additional immune effect by increasing local NK cell infiltration but not T cell on the liver cancer treatment, and this immune effect was caused by the thermal effect of BATNS photothermal treatment. Conclusions The novel BATNS could improve the stability of BPNS and simultaneously combine the cancer thermotherapy and immunotherapy leaded by local NK cell infiltration, resulting in a better therapeutic efficacy on hepatocellular carcinoma. This work also provided a new path to design BP-based materials for biomedical applications. Graphical Abstract

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Section: Resultsmentioning

confidence: 99%

Black phosphorus-Au-thiosugar nanosheets mediated photothermal induced anti-tumor effect enhancement by promoting infiltration of NK cells in hepatocellular carcinoma

et al. 2022

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“…As an essential component in most vaccines, adjuvant can enhance the immunogenicity of antigen via various ways. [14][15][16] Agonist-induced STING activation in antigen-presenting cells (APCs) not only generates IFN-β and other pro-inflammatory cytokines, but also upregulates the costimulatory signals (CD86, CD80 and CD40) and major histocompatibility complex (MHC) class I/II. These characteristics are exactly what is required for the efficient presentation of vaccine antigens and T cell immunity induction.…”

Section: Vaccine Adjuvantmentioning

confidence: 99%

Overcoming STING Agonists Barriers: Peptide, Protein, and Biomembrane‐based Biocompatible Delivery Strategies

Zheng

2022

Chemistry An Asian Journal

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After development for more than ten years, stimulator of interferon genes (STING), a representative of pattern recognition receptors (PRRs), is now entering the stage of widespread applications. Along with the evolution of STING agonists of cyclic dinucleotides (CDNs) and non‐nucleotide molecules, the stability of agonists has been improved. However, their poor performance in clinical trials triggers urgent demands for highly effective delivery strategies to further improve the cellular permeability, tissue targetability and retention. In this review, we summarized the recent progress of STING agonists applications and delivery strategies with a focus on the biocompatible platforms of peptide, protein and biomembrane, providing a novel vision for the STING field and future direction.

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“…The combined cancer treatment modality can both improve their therapeutic efficacy and lower side effects. PTT/IT BPNSs-DcF@sPL Circumvent PL pathway-regulated immune tolerance and suppression of CD8 + T cells, enhance the IFN-γ expression and promote the survival rate [131] FKF-OVAp@BPNSs Enhance antigen uptake, activate systemic immunity and prolong the survival time [135] BPNSs-bPEI-PEG-CpG Induce necroptotic cell death, activate T lymphocytes, increase serum IL-2, TNF-α and IFN-γ level, suppress both primary and distal tumors [138] hEX@BPNSs Activate immune system, inhibit tumor progression and prolong survival [141] BPNSs + aCD47…”

Section: Synergistic Cancer Photoimmunotherapy Based On Black Phosphorus Nanomaterialsmentioning

confidence: 99%

“…Thus, BP can be harnessed as an adjuvant for antigen delivery. Here, OVAp and phenylalanine-lysine-phenylalanine (FKF) were integrated onto the surface of BP nanomaterials to obtain nanovaccines termed as FKF-OVAp@BP [ 135 ]. Within tumor mild acidic environment, the electrostatic interaction between lysine and BP nanomaterials was disturbed, subsequently inducing the dissociation of antigen FKF peptide from BP nanomaterials, which enabled OVAp-mediated antigen-specific immune responses regardless of in vitro or in vivo administration.…”

Section: Delivery Of Immunotherapeutic Agents For Cancer Immunotherapymentioning

confidence: 99%

Black Phosphorus, an Emerging Versatile Nanoplatform for Cancer Immunotherapy

et al. 2021

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Black phosphorus (BP) is one of the emerging versatile nanomaterials with outstanding biocompatibility and biodegradability, exhibiting great potential as a promising inorganic nanomaterial in the biomedical field. BP nanomaterials possess excellent ability for valid bio-conjugation and molecular loading in anticancer therapy. Generally, BP nanomaterials can be classified into BP nanosheets (BPNSs) and BP quantum dots (BPQDs), both of which can be synthesized through various preparation routes. In addition, BP nanomaterials can be applied as photothermal agents (PTA) for the photothermal therapy (PTT) due to their high photothermal conversion efficiency and larger extinction coefficients. The generated local hyperpyrexia leads to thermal elimination of tumor. Besides, BP nanomaterials are capable of producing singlet oxygen, which enable its application as a photosensitizer for photodynamic therapy (PDT). Moreover, BP nanomaterials can be oxidized and degraded to nontoxic phosphonates and phosphate under physiological conditions, improving their safety as a nano drug carrier in cancer therapy. Recently, it has been reported that BP-based PTT is capable of activating immune responses and alleviating the immunosuppressive tumor microenvironment by detection of T lymphocytes and various immunocytokines, indicating that BP-based nanocomposites not only serve as effective PTAs to ablate large solid tumors but also function as an immunomodulation agent to eliminate discrete tumorlets. Therefore, BP-mediated immunotherapy would provide more possibilities for synergistic cancer treatment.

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Black phosphorous nanosheet: A novel immune-potentiating nanoadjuvant for near-infrared-improved immunotherapy

Cited by 53 publications

References 53 publications

Black phosphorus-Au-thiosugar nanosheets mediated photothermal induced anti-tumor effect enhancement by promoting infiltration of NK cells in hepatocellular carcinoma

Black phosphorus-Au-thiosugar nanosheets mediated photothermal induced anti-tumor effect enhancement by promoting infiltration of NK cells in hepatocellular carcinoma

Overcoming STING Agonists Barriers: Peptide, Protein, and Biomembrane‐based Biocompatible Delivery Strategies

Black Phosphorus, an Emerging Versatile Nanoplatform for Cancer Immunotherapy

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