Black Phosphorus Nanosheet‐Based Drug Delivery System for Synergistic Photodynamic/Photothermal/Chemotherapy of Cancer

Chen, Wansong; Ouyang, Jun; Liu, Hong; Chen, Min; Zeng, Ke; Sheng, Jianping; Liu, Zhenjun; Han, Yuge; Li, Juan; Liu, Deng; Guo, Shaojun

doi:10.1002/adma.201603864

Cited by 861 publications

(697 citation statements)

References 32 publications

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“…[11][12][13][14][15][16][17] However, the previously reported ultrathin 2D nanomaterials are mainly based on a "top-down" mechanical-exfoliation strategy, which show difficulties in the control over particle size, thickness, morphology, and uniformity. Moreover, some 2D nanomaterials (e.g., graphene, TMDs, and BP) with a strong near-infrared (NIR) optical absorption can serve as photothermal or photodynamic agents, which combine with drugs to realize synergistic treatment.…”

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confidence: 99%

Monolayer Nanosheets with an Extremely High Drug Loading toward Controlled Delivery and Cancer Theranostics

et al. 2018

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2D nanomaterials have attracted considerable research interest in drug delivery systems, owing to their intriguing quantum size and surface effect. Herein, Gd -doped monolayered-double-hydroxide (MLDH) nanosheets are prepared via a facile bottom-up synthesis method, with a precisely controlled composition and uniform morphology. MLDH nanosheets as drug carrier are demonstrated in coloading of doxorubicin and indocyanine green (DOX&ICG), with an ultrahigh drug loading content (LC) of 797.36% and an encapsulation efficiency (EE) of 99.67%. This is, as far as it is known, the highest LC level at nearly 100% of EE among previously reported 2D drug delivery systems so far. Interestingly, the as-prepared DOX&ICG/MLDH composite material shows both pH-controlled and near-infrared-irradiation-induced DOX release, which holds a promise in stimulated drug release. An in vivo dual-mode imaging, including near-infrared fluorescence and magnetic resonance imaging, enables a noninvasive visualization of distribution profiles at the tumor site. In addition, in vitro and in vivo therapeutic evaluations demonstrate an excellent trimode synergetic anticancer activity and superior biocompatibility of DOX&ICG/MLDH. Therefore, MLDH nanosheets provide new perspectives in the design of multifunctional nanomedicine, which shows promising applications in controlled drug delivery and cancer theranostics.

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confidence: 99%

Monolayer Nanosheets with an Extremely High Drug Loading toward Controlled Delivery and Cancer Theranostics

et al. 2018

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“…Few-layer black phosphorus (BP) or phosphorene when down to a single layer, a new member recently added to the two dimensional material family, has been intensively investigated due to the great potential for application in nano-electronics [1][2][3][4][5][6][7] , opto-electronics 2, [8][9][10][11][12] , bio-medical therapy [13][14][15][16][17] , energy storage 18,19 , gas sensors 20 , etc.…”

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confidence: 99%

Electrically Tunable Energy Bandgap in Dual-Gated Ultra-Thin Black Phosphorus Field Effect Transistors

Yan¹,

Xie²,

Chen³

et al. 2017

Chinese Phys. Lett.

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The energy bandgap is an intrinsic character of semiconductors which largely determines their properties. The ability to continuously and reversibly tune the bandgap of a single device during real time operation is of great importance not only to device physics but also to technological applications. Here we demonstrate a widely tunable bandgap of few-layer black phosphorus (BP) by the application of vertical electric field in dual-gated BP field-effect transistors (FETs). A total bandgap reduction of 124 meV is observed when the electrical displacement field is increased from 0.10V/nm to 0.83V/nm. Our results suggest appealing potential for few-layer BP as a tunable

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“…[7][8][9] Among various combination therapies, the combination of PTT with chemotherapy has showed a superior treatment effect in case of prostate cancer. 10,11 PTT usually utilizes near-infrared (NIR) lightabsorbing photosensitizers to damage tumor cells with laser irradiation by heating. 12 However, both photosensitizers and chemotherapeutic agents lack tumor-targeted accumulation and can be easily eliminated from the body.…”

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confidence: 99%

Self-assembled albumin nanoparticles for combination therapy in prostate cancer

Lian

et al. 2017

IJN

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Resistance to regular treatment strategies is a big challenge in the treatment of castration-resistant prostate cancer. Combination of photothermal and photodynamic therapy (PTT/PDT) with chemotherapy offers unique advantages over monotherapy alone. However, free drugs, such as photosensitizers and chemotherapeutic agents, lack tumor-targeted accumulation and can be easily eliminated from the body. Moreover, most of the PTT drugs are hydrophobic and their organic solvents have in vivo toxicity, thereby limiting their potential in clinical translation. Herein, simple multifunctional nanoparticles (NPs) using IR780 (a near-infrared dye) and docetaxel (DTX)-loaded nanoplatform based on human serum albumin (HSA) (HSA@IR780@DTX) was developed for targeted imaging and for PTT/PDT with chemotherapy for the treatment of castration-resistant prostate cancer treatment. In this platform, HSA is a biocompatible nanocarrier that binds to both DTX and IR780. DTX and IR780, as hydrophobic drug, can induce the self-assembly of HSA proteins. Transmission electron microscopic imaging showed that NPs formed by self-assembly are spherical with a smooth surface with a hydrodynamic diameter of 146.5±10.8 nm. The cytotoxicity of HSA@IR780@DTX NPs with or without laser irradiation in prostate cancer cells (22RV1) was determined via CCK-8 assay. The antitumor effect of HSA@IR780@DTX plus laser irradiation was better than either HSA@IR780@DTX without laser exposure or single PTT heating induced by HSA@IR780 NPs under near-infrared laser, suggesting a significant combined effect in comparison to monotherapy. Near-infrared fluorescence imaging showed that HSA@IR780@DTX NPs could preferentially accumulate in tumors. In vivo therapeutic efficacy experiment showed that xenografted prostate tumors on mice treated with HSA@IR780@DTX plus near-infrared laser irradiation were completely inhibited, whereas tumors on mice treated with chemotherapy alone (HSA@DTX and HSA@IR780@DTX without laser) or PTT/PDT alone (HSA@IR780 with laser) showed moderate growth inhibition. Overall, HSA@IR780@DTX NPs showed notable targeting and theranostic potential for the treatment of castration-resistant prostate cancer.

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Black Phosphorus Nanosheet‐Based Drug Delivery System for Synergistic Photodynamic/Photothermal/Chemotherapy of Cancer

Cited by 861 publications

References 32 publications

Monolayer Nanosheets with an Extremely High Drug Loading toward Controlled Delivery and Cancer Theranostics

Monolayer Nanosheets with an Extremely High Drug Loading toward Controlled Delivery and Cancer Theranostics

Electrically Tunable Energy Bandgap in Dual-Gated Ultra-Thin Black Phosphorus Field Effect Transistors

Self-assembled albumin nanoparticles for combination therapy in prostate cancer

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