Black Phosphorus Quantum Dots Gated, Carbon‐Coated Fe3O4 Nanocapsules (BPQDs@ss‐Fe3O4@C) with Low Premature Release Could Enable Imaging‐Guided Cancer Combination Therapy

Zhang, Ming; Wang, Wentao; Wu, Fan; Graveran, Kathleen; Zhang, Jun; Wu, Changzhu

doi:10.1002/chem.201801085

Cited by 50 publications

(28 citation statements)

References 49 publications

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“…Similarly, individual differences often lead to uncertainty about the effectiveness of treatment. [116,117] administration. The main drawbacks of these DDSs include the following: 1) drugs are released in an initial burst when the DDS first enters the physiological environment; 2) exposure of the drugs in vivo before they reach the target cells leads them to decompose or denature; 3) the drugs' biodistribution can be altered by nonspecific cells and physiological conditions; 4) some drug molecules cannot distinguish between diseased and healthy cells, which can lead to collateral damage and undesired side effects for normal tissues and organs.…”

Section: Reduction Of Disulfide Bondsmentioning

confidence: 99%

Current Advances in Black Phosphorus‐Based Drug Delivery Systems for Cancer Therapy

et al. 2021

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Cancer has been one of the major threats to the lives of human beings for centuries. Traditional therapy is more or less faced with certain defects, such as poor targeting, easy degradation, high side effects, etc. Therefore, in order to improve the treatment efficiency of drugs, an intelligent drug delivery system (DDS) is considered as a promising solution strategy. Due to their special structure and large specific surface area, 2D materials are considered to be a good platform for drug delivery. Black phosphorus (BP), as a new star of the 2D family, is recommended to have the potential to construct DDS by virtue of its outstanding photothermal therapy (PTT), photodynamic therapy (PDT), and biodegradable properties. This tutorial review is intended to provide an introduction of the current advances in BP‐based DDSs for cancer therapy, which covers topics from its construction, classified by the types of platforms, to the stimuli‐responsive controlled drug release. Moreover, their cancer therapy applications including mono‐, bi‐, and multi‐modal synergistic cancer therapy as well as the research of biocompatibility are also discussed. Finally, the current status and future prospects of BP‐based DDSs for cancer therapy are summarized.

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Section: Reduction Of Disulfide Bondsmentioning

confidence: 99%

Current Advances in Black Phosphorus‐Based Drug Delivery Systems for Cancer Therapy

et al. 2021

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“…This multistage pH-sensitive property resulted in enhanced tumor penetration (as seen in both MRI and NIRF imaging), long retention time, and excellent chemotherapy-PDT synergistic anti-tumor treatment efficacy against MGC-803 tumors in mice, with complete tumor ablation observed after 15 days. Meanwhile, Zhang et al developed black phosphorus quantum dots gated, carbon‐coated Fe 3 O 4 nanocapsules with pH, NIR, and redox triple-stimuli responsive behavior for continuous DOX release at the tumor site 165 . With magnetic- and EGFR-targeting, the nanocapsules efficiently accumulated within A549 tumors and were monitored using both T2-weighted MRI and fluorescence imaging.…”

Section: Mri-guided Nanoparticles For Combination Therapymentioning

confidence: 99%

MRI-traceable theranostic nanoparticles for targeted cancer treatment

Anani¹,

Rahmati²,

Nayer³

et al. 2021

Theranostics

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Current cancer therapies, including chemotherapy and radiotherapy, are imprecise, non-specific, and are often administered at high dosages - resulting in side effects that severely impact the patient's overall well-being. A variety of multifunctional, cancer-targeted nanotheranostic systems that integrate therapy, imaging, and tumor targeting functionalities in a single platform have been developed to overcome the shortcomings of traditional drugs. Among the imaging modalities used, magnetic resonance imaging (MRI) provides high resolution imaging of structures deep within the body and, in combination with other imaging modalities, provides complementary diagnostic information for more accurate identification of tumor characteristics and precise guidance of anti-cancer therapy. This review article presents a comprehensive assessment of nanotheranostic systems that combine MRI-based imaging (T1 MRI, T2 MRI, and multimodal imaging) with therapy (chemo-, thermal-, gene- and combination therapy), connecting a range of topics including hybrid treatment options ( e.g. combined chemo-gene therapy), unique MRI-based imaging ( e.g. combined T1-T2 imaging, triple and quadruple multimodal imaging), novel targeting strategies ( e.g. dual magnetic-active targeting and nanoparticles carrying multiple ligands), and tumor microenvironment-responsive drug release ( e.g. redox and pH-responsive nanomaterials). With a special focus on systems that have been tested in vivo , this review is an essential summary of the most advanced developments in this rapidly evolving field.

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“…Capitalizing on this feature, the PDA-modified BP can be readily decorated with specific ligands, e.g., aptamers for tumor targeting purpose [226]. BPQDs utilized as photothermal agents have also been reported in recent years [199,227]. Because of their superior physicochemical properties, they have shown the possibility for combined therapy, e.g., chemotherapy, immunotherapy, PTT and PDT [228][229][230].…”

Section: Xenesmentioning

confidence: 99%

Recent advance in near-infrared/ultrasound-sensitive 2D-nanomaterials for cancer therapeutics

et al. 2020

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In recent years, the emerging two-dimensional (2D) nanomaterials have shown great potential for a variety of applications such as electronics, catalysis, supercapacitors, and energy materials. In the biomedical arena, these nanomaterials, especially 2D-ultrathin nanomaterials, have also been regarded as promising nano-carriers and/or diagnostic agents for cancer diagnosis and treatment, owing to their remarkable mechanical, photothermal, and optical properties. In this review, we provide the recent development of the nanoplatforms based on near-infrared/ultrasound-sensitive 2D-materials, representatively such as graphdiyne (GDY), black phosphorus, transition metal dichalcogenides (TMDs), and antimonene, for non-invasive cancer therapeutics including photothermal, photodynamic and sonodynamic approaches. The general properties of these 2D nanomaterials linking to biomedical interests are first introduced, followed by the fabrication processes of diverse nano-platforms and related outcomes of cancer diagnosis and treatments. We also outline the current challenges and prospects of the 2D materials for non-invasive approaches to cancer treatments in the future.

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Black Phosphorus Quantum Dots Gated, Carbon‐Coated Fe₃O₄ Nanocapsules (BPQDs@ss‐Fe₃O₄@C) with Low Premature Release Could Enable Imaging‐Guided Cancer Combination Therapy

Cited by 50 publications

References 49 publications

Current Advances in Black Phosphorus‐Based Drug Delivery Systems for Cancer Therapy

Current Advances in Black Phosphorus‐Based Drug Delivery Systems for Cancer Therapy

MRI-traceable theranostic nanoparticles for targeted cancer treatment

Recent advance in near-infrared/ultrasound-sensitive 2D-nanomaterials for cancer therapeutics

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