Black raspberry anthocyanins increased the antiproliferative effects of 5-Fluorouracil and Celecoxib in colorectal cancer cells and mouse model

Li, Xin; Chen, Lili; Gao, Yunqiu; Zhang, Qiuhua; Chang, Alan K.; Yang, Zhe; Bi, Xiuli

doi:10.1016/j.jff.2021.104801

Cited by 16 publications

(13 citation statements)

References 45 publications

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“…Indeed, co-incubation of HT-29 cells with 5-FU and PAM further decreased cell migration compared with 5-FU treatment alone. Similarly, Li et al recently reported that black raspberry anthocyanins significantly increased the anti-proliferative and anti-migratory effects of 5-FU and Celecoxib in colon cancer cell lines [ 55 ]. However, proliferation of Caco-2 cells was not affected by single treatment with black raspberry anthocyanins [ 55 ].…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, Li et al recently reported that black raspberry anthocyanins significantly increased the anti-proliferative and anti-migratory effects of 5-FU and Celecoxib in colon cancer cell lines [ 55 ]. However, proliferation of Caco-2 cells was not affected by single treatment with black raspberry anthocyanins [ 55 ]. Accordingly, physiological concentrations of anthocyanins and their metabolites might possibly enhance the anti-migratory effect of 5-FU in Caco-2 cells.…”

Section: Discussionmentioning

confidence: 99%

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Influence of Plasma-Isolated Anthocyanins and Their Metabolites on Cancer Cell Migration (HT-29 and Caco-2) In Vitro: Results of the ATTACH Study

et al. 2022

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Cancer mortality is mainly due to metastasis. Therefore, searching for new therapeutic agents suppressing cancer cell migration is crucial. Data from human studies regarding effects of anthocyanins on cancer progression, however, are scarce and it is unclear whether physiological concentrations of anthocyanins and their metabolites reduce cancer cell migration in vivo. In addition, interactions with chemotherapeutics like 5-fluorouracil (5-FU) are largely unknown. Thus, we combined a placebo-controlled, double-blinded, cross-over study with in vitro migration studies of colon cancer cell lines to examine the anti-migratory effects of plasma-isolated anthocyanins and their metabolites (PAM). Healthy volunteers (n = 35) daily consumed 0.33 L of an anthocyanin-rich grape/bilberry juice and an anthocyanin-depleted placebo juice for 28 days. PAM were isolated before and after intervention by solid-phase extraction. HT-29 and Caco-2 cells were incubated with PAM in a Boyden chamber. Migration of HT-29 cells was significantly inhibited by PAM from juice but not from placebo. In contrast, Caco-2 migration was not affected. Co-incubation with 5-FU and pooled PAM from volunteers (n = 10), which most effectively inhibited HT-29 migration, further reduced HT-29 migration in comparison to 5-FU alone. Therefore, PAM at physiological concentrations impairs colon cancer cell migration and may support the effectiveness of chemotherapeutics.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Influence of Plasma-Isolated Anthocyanins and Their Metabolites on Cancer Cell Migration (HT-29 and Caco-2) In Vitro: Results of the ATTACH Study

et al. 2022

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“…For instance, Yin et al reported that cyanidin 3 glucoside chloride acts along with luteolin by increasing apoptosis and inhibiting the proliferation of breast and colon cancer cell lines [ 287 ]. Regarding combining anthocyanins with other chemotheraputic agents, Li et al revealed that a combination of 5-FU and 50 μg/mL blackberries anthocyanins decreased the proliferation and migration of SW480 cells in colorectal cancer [ 288 ]. Paramanantham et al stated that 400 µg/mL of anthocyanins isolated from Coignetiae pulliat had advanced the sensitivity of cisplatin in MCF-7 breast cancer cells resulting from the impairment of Akt and NF-κB activation [ 289 ].…”

Section: Combination Therapies Based On Selected Natural Productsmentioning

confidence: 99%

Combination Anticancer Therapies Using Selected Phytochemicals

et al. 2022

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Cancer is still one of the most widespread diseases globally, it is considered a vital health challenge worldwide and one of the main barriers to long life expectancy. Due to the potential toxicity and lack of selectivity of conventional chemotherapeutic agents, discovering alternative treatments is a top priority. Plant-derived natural products have high potential in cancer treatment due to their multiple mechanisms of action, diversity in structure, availability in nature, and relatively low toxicity. In this review, the anticancer mechanisms of the most common phytochemicals were analyzed. Furthermore, a detailed discussion of the anticancer effect of combinations consisting of natural product or natural products with chemotherapeutic drugs was provided. This review should provide a strong platform for researchers and clinicians to improve basic and clinical research in the development of alternative anticancer medicines.

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“…In a broad sense, anthocyanidins (ACNs) present a subclass of flavonoids that have not been well investigated for their chemo-sensitizing and radio-sensitizing effects. Indeed, black raspberry ACNs improved the efficacy of two chemotherapeutic agents (5-FU and celecoxib); in vitro by inhibiting the proliferation of CRC cells and in vivo by decreasing the number of CRC tumors in animals [ 44 ]. Recently, specific molecules of this family, such as delphinidin [ 45 ] and cyanidin-3-glucoside (C3G) [ 46 ], have been studied.…”

Section: Dietary Phenolic Compounds Improving the Chemosensitivity Of...mentioning

confidence: 99%

Advances in Dietary Phenolic Compounds to Improve Chemosensitivity of Anticancer Drugs

Bouyahya

Omari

Bakrim

et al. 2022

Cancers

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Despite the significant advances and mechanistic understanding of tumor processes, therapeutic agents against different types of cancer still have a high rate of recurrence associated with the development of resistance by tumor cells. This chemoresistance involves several mechanisms, including the programming of glucose metabolism, mitochondrial damage, and lysosome dysfunction. However, combining several anticancer agents can decrease resistance and increase therapeutic efficacy. Furthermore, this treatment can improve the effectiveness of chemotherapy. This work focuses on the recent advances in using natural bioactive molecules derived from phenolic compounds isolated from medicinal plants to sensitize cancer cells towards chemotherapeutic agents and their application in combination with conventional anticancer drugs. Dietary phenolic compounds such as resveratrol, gallic acid, caffeic acid, rosmarinic acid, sinapic acid, and curcumin exhibit remarkable anticancer activities through sub-cellular, cellular, and molecular mechanisms. These compounds have recently revealed their capacity to increase the sensitivity of different human cancers to the used chemotherapeutic drugs. Moreover, they can increase the effectiveness and improve the therapeutic index of some used chemotherapeutic agents. The involved mechanisms are complex and stochastic, and involve different signaling pathways in cancer checkpoints, including reactive oxygen species signaling pathways in mitochondria, autophagy-related pathways, proteasome oncogene degradation, and epigenetic perturbations.

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Black raspberry anthocyanins increased the antiproliferative effects of 5-Fluorouracil and Celecoxib in colorectal cancer cells and mouse model

Cited by 16 publications

References 45 publications

Influence of Plasma-Isolated Anthocyanins and Their Metabolites on Cancer Cell Migration (HT-29 and Caco-2) In Vitro: Results of the ATTACH Study

Influence of Plasma-Isolated Anthocyanins and Their Metabolites on Cancer Cell Migration (HT-29 and Caco-2) In Vitro: Results of the ATTACH Study

Combination Anticancer Therapies Using Selected Phytochemicals

Advances in Dietary Phenolic Compounds to Improve Chemosensitivity of Anticancer Drugs

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