Black tea protects immunocytes from tumor-induced apoptosis by changing Bcl-2/Bax ratio

Bhattacharyya, Arindam; Mandal, Deba Prasad; Lahiry, Lakshmishri; Sa, Gaurisankar; Das, Tanya

doi:10.1016/j.canlet.2003.12.025

Cited by 50 publications

(27 citation statements)

References 28 publications

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“…In Sarcoma 180-bearing mice model, evident reduction in splenic lymphocytes was observed, reinforcing the notion that tumor development inside the host resulted in the impairment of normal lymphocytes and the reduction of proliferative potential, which was in accordance with those previously reported [26,15] . The search for underlying mechanisms revealed apoptosis as the cause of tumor-induced immune cell death in spleen [27] .…”

Section: Discussionsupporting

confidence: 90%

“…Such down-regulations in tumor-bearing mice are likely due to the immunomodulatory effect of polysaccharides present in AEI that higher dose of polysaccharides usually attenuates over-activation of host immune system [20] . The growth or regression of a tumor inside the host body largely depends on the expression of bax and bcl-2 genes [14,15] . Many anticancer drugs exert their lethality by inducing apoptosis of tumor cells both in vitro and in vivo via mitochondrial or death receptor pathway [28,29] .…”

Section: Discussionmentioning

confidence: 99%

“…A number of studies raised the possibilities that tumors of both mouse and human origin can evade immune surveillance by delivering apoptotic death signals to lymphocytes [12] . The growth or regression of a tumor inside host body depends on its status of cell proliferation and on apoptosis [13] , namely, the progression of a tumor inside host body is determined by the expression of bax and bcl-2 genes [14,15] . Bax belongs to the bcl-2 family, the products of which regulate cell death; while the products of bcl-2 are recognized as a survival factor for many types of cells including tumor cells [13] .…”

Section: Introductionmentioning

confidence: 99%

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Aqueous Extract of Inonotus bliquus (Fr.) Pilat (Hymenochaetaceae) Significantly Inhibits the Growth of Sarcoma 180 by Inducing Apoptosis

Chen¹,

Zheng²,

Gao³

et al. 2007

American J. of Pharmacology and Toxicology

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Inonotus obliquus (Fr.) Pilat (Hymenochaetaceae) has been widely used as a folk medicine to treat various cancers in Russia, Poland and most of Baltic countries for literally more than four centuries. However, in spite of its therapeutic significance for cancers, this fungus has not been studied systematically for the mechanisms of antitumor activity. In this study, we report the effects of aqueous extracts of I. obliquus (AEI) on inducing apoptosis of Sarcoma 180. AEI prepared from the sclerotium of I. obliquus was either administered to Sarcoma 180-bearing mice or supplemented into the culture of Sarcoma 180 cells. Oral administration of AEI significantly inhibited Sarcoma 180-induced reduction of splenic lymphocytes and proliferation potentials and elicited over-expression of bax gene in Sarcoma 180 cells, leading to the regression of Sarcoma 180 in mice. Supplementation of AEI into the culture of Sarcoma 180 cells resulted in a significant increase in the number of cells in G0-G1 phase and triggered remarkable increment in programmed death (apoptosis) of Sarcoma 180 cells. In addition, AEI showed stimulatory effect on TNF-α release by mice peritoneal macrophages. These results indicated that the antitumor activity of AEI was mediated by protecting splenic lymphocytes from tumor-induced apoptosis and by triggering apoptosis of tumor cells.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Aqueous Extract of Inonotus bliquus (Fr.) Pilat (Hymenochaetaceae) Significantly Inhibits the Growth of Sarcoma 180 by Inducing Apoptosis

Chen¹,

Zheng²,

Gao³

et al. 2007

American J. of Pharmacology and Toxicology

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“…Tea consumption reduces the risk of heart disease and stroke (3,4). Tea compounds by many mechanisms such as reducing free radical and DNA damage, inhibiting uncontrolled cell growth, and boosting the immune system help stave off the development of cancer cells and provide chemo-protection for our body (5). Although many of the potential beneficial effects of tea have been attributed to the strong antioxidant activity of tea polyphenols, the precise mechanism by which tea might help prevent cancer has not been established (6).…”

Section: Dear Editormentioning

confidence: 99%

The Relationship Between Tea Consumption and Cancer

Khazaei¹,

Salehiniya²,

Delavar³

et al. 2015

Avicenna J Med Biochem

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“…However, Bcl‐2 can inhibit Bax‐induced apoptosis by forming heterodimers with Bax 21. Thus, the ratio of Bcl‐2 and Bax expression is considered to be important for the regulation of cellular apoptosis 22, 23, 24…”

Section: Introductionmentioning

confidence: 99%

Expression of cytokine‐induced neutrophil chemoattractant suppresses tumor necrosis factor alpha expression and thereby prevents the follicles from undergoing atresia and apoptosis

Tanaka

Kuwahara

Ushigoe

et al. 2017

Reprod Medicine & Biology

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AimCytokine‐induced neutrophil chemoattractant (CINC/gro) is a CXC family chemokine, similar to interleukin‐8 in rats, and is one of the factors that regulates ovulation. However, the mechanism that regulates atresia of the ovaries postovulation is not clearly defined.MethodsWhether antibody‐blocking of CINC/gro can alter the number of ovulated oocytes and modulate neutrophil infiltration was investigated. The effect of the antibody on the level of inflammatory cytokine production and follicular atresia was examined. Apoptosis was measured by the terminal deoxynucleotidyl transferase‐mediated dUTP nick end labeling (TUNEL) method and via analysis of the messenger RNA expression of Bcl‐2 and Bcl2‐associated X (Bax).ResultsThe anti‐CINC/gro antibody treatment decreased the number of ovulated oocytes. The messenger RNA levels of cyclooxygenase‐2 and interleukin‐1 beta were decreased by the antibody treatment, whereas that of tumor necrosis factor (TNF) alpha was increased. The TUNEL analysis revealed a larger number of apoptotic cells in the antibody group, compared with those in the control group, as well as a significant increase in the Bax/Bcl‐2 ratio 24 hours after human chorionic gonadotropin administration.ConclusionThese findings suggest that ovulation is accelerated by neutrophil infiltration into the theca layer. The CINC/gro appears to synergize with interleukin‐1 beta for ovulation. By contrast, the data suggest that CINC/gro expression suppresses TNF alpha expression and that CINC/gro expression therefore prevents the follicles from undergoing atresia and apoptosis.

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Black tea protects immunocytes from tumor-induced apoptosis by changing Bcl-2/Bax ratio

Cited by 50 publications

References 28 publications

Aqueous Extract of Inonotus bliquus (Fr.) Pilat (Hymenochaetaceae) Significantly Inhibits the Growth of Sarcoma 180 by Inducing Apoptosis

Aqueous Extract of Inonotus bliquus (Fr.) Pilat (Hymenochaetaceae) Significantly Inhibits the Growth of Sarcoma 180 by Inducing Apoptosis

The Relationship Between Tea Consumption and Cancer

Expression of cytokine‐induced neutrophil chemoattractant suppresses tumor necrosis factor alpha expression and thereby prevents the follicles from undergoing atresia and apoptosis

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