Bladder cancer SNP panel predicts susceptibility and survival

Abstract

Bladder cancer is the fourth most common malignancy in men and the eighth most common in women in western countries. Single nucleotide polymorphisms (SNPs) in genes that regulate telomere maintenance, mitosis, inflammation, and apoptosis have not been assessed extensively for this disease. Using a population-based study with 832 bladder cancer cases and 1,191 controls, we assessed genetic variation in relation to cancer susceptibility or survival. Findings included an increased risk associated with variants in the methyl-metabolism gene, MTHFD2 (OR 1.7 95% CI 1.3–2.3), the telomerase TEP1 (OR 1.8 95% CI 1.2–2.6) and decreased risk associated with the inflammatory response gene variant IL8RB (OR 0.6 95% CI 0.5–0.9) compared to wild-type. Shorter survival was associated with apoptotic gene variants, including CASP9 (HR 1.8 95% CI 1.1–3.0). Variants in the detoxification gene EPHX1 experienced longer survival (HR 0.4 (95% CI 0.2–0.8). These genes can now be assessed in multiple study populations to identify and validate SNPs appropriate for clinical use.

MicroRNA-9 Inhibition of Cell Proliferation and Identification of Novel miR-9 Targets by Transcriptome Profiling in Breast Cancer Cells

“…MTHFD2, a mitochondrial bifunctional enzyme, is known to involve in folate metabolism (73), and loss-or gain-of function studies have not been described yet. A possible link between MTHFD2 and cancer, such as a SNP in MTHFD2 associated with increased risk of bladder cancer (74), and a correlation of MTHFD2 expression with artesunate resistance in tumor cell lines (75) have been reported.…”

The Role of Molecular Mechanisms in the Development of Bladder Carcinoma: Review

“…EPHX1 var yantla rı uzun sağ ka lım la iliş ki len di ril miş tir. 137 Mi ye lo pe ro si daz (MPO), sul fot rans fe raz lar (SULT), UDP-glu ko ro no sil tran fe raz lar (UGT), kate kol-o-me til trans fe raz (COMT), man ga naz sü peTurkiye Klinikleri J Med Sci 2011;31 (1) rok sit dis mu taz (MnSOD) ve glu ta ti on pe rok si daz 1 (GPX1) gi bi kar si no jen me ta bo liz ma sıy la iliş ki lendi ri le bi le cek gen ler de ki po li mor fizm ler de ça lı şıl -mış tır. An cak el de edi len so nuç lar çe liş ki li dir ve her han gi bir so nu ca gö tür me mek te dir.…”

“…An drew ve ar ka daş la rı yap tı ğı ge niş bir ça lış ma da, CASP9 gen var yant la rı ile kı sa sağ ka lım ara sın da an lam lı bir iliş ki ol du ğu nu bul muş lar dır. 137 Özet le, bi rey ler de ki ge ne tik po li mor fizm le re bağ lı fark lı lık lar, me sa ne kan se ri ge liş me ris ki ni değiş ti re bil mek te dir. Ba zı po li mor fik al le ler me sa ne kan se ri ris ki ni art tır mak ta, ba zı la rı bu ris ki azaltmak ta, ba zı la rı yal nız ca çev re sel bir fak tö rün (kimya sal mad de ler, si ga ra vb.)…”

The Role of 22 Genes Expression in Bladder Cancer by Adaptive LASSO

“…It is the fourth most common cancer, the ninth cause of cancer death in males and the eighth most common cancer in females (1,2). Every year 330,000 people throughout the world are diagnosed with bladder cancer (3).…”