Bladder inflammation and hypogastric neurectomy influence uterine motility in the rat

Dmitrieva, Natalia O.; Johnson, Orenda L.; Berkley, Karen J.

doi:10.1016/s0304-3940(01)02247-9

Cited by 36 publications

(37 citation statements)

References 14 publications

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“…Given the robust effects of bladder inflammation on colon and uterine horn activity reported, respectively, by Pezzone et al (55) and Dmitrieva et al (22), the small effects observed here on the colon and uterine horn were surprising. There are several possible explanations.…”

Section: Discussionmentioning

confidence: 38%

“…Another possibility is a difference in timing. We studied the bladder-to-colon effects 2 h after inflammation, whereas Pezzone et al (55) studied them ϳ60 min after irritation, and Dmitrieva et al (22) found that the bladder-to-uterus effects were maximal at times later than our measurements here (4 h). A third possibility is a difference in the agents used for irritation/inflammation: protamine sulfate followed by potassium chloride or 50% turpentine, respectively, vs. 10% MO here.…”

Section: Discussionmentioning

confidence: 79%

“…Our findings of cross-organ effects between pelvic organs in the gastrointestinal, urinary, and reproductive tracts are consistent with earlier reports. Previously, we showed that acute bladder inflammation in proestrus decreases contractions of the untreated uterine horn (22). Acute bladder inflammation also reduces the efficacy of cannabinoid agonists on the uterine horn (21).…”

Section: Discussionmentioning

confidence: 86%

“…The HYPX was done by identifying the left and right hypogastric nerves where they exit distally from the inferior mesenteric ganglion (IMG), freeing them completely from connective tissue, cutting them, and separating the cut ends from each other. The 1-h delay was chosen because other studies have shown that the effects of HYPX are evident at that time (22).…”

Section: Methodsmentioning

confidence: 99%

“…Recent physiological and behavioral data from studies on rodents support such a possibility. Thus acute bladder inflammation in rats increases the motility of the uninflamed uterus (22) and reduces the efficacy of drugs on the uninflamed uterus (21). In addition, acute inflammation of the rat colon or prostate, as well as chronic abdominal pathology (surgically induced endometriosis) produces signs of inflammation in the otherwise healthy bladder (18,41,50,55,71).…”

mentioning

confidence: 99%

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Cross-organ interactions between reproductive, gastrointestinal, and urinary tracts: modulation by estrous stage and involvement of the hypogastric nerve

Winnard¹,

Dmitrieva²,

Berkley³

2006

American Journal of Physiology-Regulatory, Integrative and Comp

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101

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-Central nervous system neurons process information converging from the uterus, colon, and bladder, partly via the hypogastric nerve. This processing is influenced by the estrous cycle, suggesting the existence of an estrous-modifiable central nervous system substrate by which input from one pelvic organ can influence functioning of other pelvic organs. Here, we tested predictions from this hypothesis that acute inflammation of colon, uterine horn, or bladder would produce signs of inflammation in the other uninflamed organs (increase vascular permeability) and that cross-organ effects would vary with estrous and be eliminated by hypogastric neurectomy (HYPX). Under urethane anesthesia, the colon, uterine horn, or bladder of rats in proestrus or metestrus, with or without prior HYPX, was treated with mustard oil or saline. Two hours later, Evans Blue dye extravasation was measured to assess vascular permeability. Extravasation was increased in all inflamed organs, regardless of estrous stage. For rats in proestrus, but not metestrus, either colon or uterine horn inflammation significantly increased extravasation in the uninflamed bladder. Much smaller cross-organ effects were seen in colon and uterine horn. HYPX reduced extravasation in the inflamed colon and inflamed uterine horn, but not the inflamed bladder. HYPX eliminated the colon-to-bladder and uterine horn-to-bladder effects. These results demonstrate that inflaming one pelvic organ can produce estrous-modifiable signs of inflammation in other pelvic organs, particularly bladder, and suggest that the cross-organ effects involve the hypogastric nerve and are at least partly centrally mediated. Such effects could contribute to cooccurrence and cyclicity of distressing pelvic disorders in women. pelvic pain; inflammation; interstitial cystitis; uterus; colon NEURAL COORDINATION AND decision-making for many physiological and behavioral functions depends on convergence within the nervous system of information from different bodily regions (for example, see Ref 4). Such is the case, for example, in the control of walking, balance, posture, eye movements, blood pressure, fight/flight responses, and other sensorimotor functions (39). Much of this convergence involves heterotopic interactions between different somatic structures (muscles/ skin) or between somatic and visceral structures.Such coordination is less well understood between different internal organs; that is, viscerovisceral interactions. Studies have shown, however, that neurons in the spinal cord, dorsal column nuclei, solitary nucleus, medullary reticular formation, and thalamus process information that converges from different internal organs located in different functional systems, i.e., the reproductive, gastrointestinal, and urinary tracts (8,9,11,17,24,31,32,37,57,58,59,60). In some regions, this processing is robustly influenced by the estrous cycle and hormone manipulations (15,16).This cross-system, viscerovisceral convergence supports the concept that the nervous system provides a dynamic ...

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Section: Discussionmentioning

confidence: 38%

Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 86%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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Cross-organ interactions between reproductive, gastrointestinal, and urinary tracts: modulation by estrous stage and involvement of the hypogastric nerve

Winnard¹,

Dmitrieva²,

Berkley³

2006

American Journal of Physiology-Regulatory, Integrative and Comp

Self Cite

101

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Estrogen receptor-α mediates estradiol attenuation of ATP-induced Ca2+ signaling in mouse dorsal root ganglion neurons

Chaban

Micevych

2005

J. Neurosci. Res.

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A mechanism underlying gender-related differences in pain perception may be estrogen modulation of nociceptive signaling in the peripheral nervous system. In rat, dorsal root ganglion (DRG) neurons express estrogen receptors (ERs) and estrogen rapidly attenuates ATP-induced Ca2+ signaling. To determine which estrogen receptor mediates rapid actions of estrogen, we showed ERalpha and ERbeta expression in DRG neurons from wild-type (WT) female mice by RT-PCR. To study whether ERalpha or ERbeta mediates this response, we compared estradiol action mediating Ca2+ signaling in DRG neurons from WT, ERalpha knockout (ERalphaKO), and ERbetaKO mice in vitro. ATP, an algesic agent, induced [Ca2+]i transients in 48% of small DRG neurons from WT mice. 17beta-Estradiol (E2) inhibited ATP-induced intracellular Ca2+ concentration ([Ca2+]i) with an IC50 of 27 nM. The effect of E2 was rapid (5-min exposure) and stereo specific; 17alpha-estradiol had no effect. E2 action was blocked by the ER antagonist ICI 182,780 (1 microM) in WT mouse. Estradiol coupled to bovine serum albumin (E-6-BSA), which does not penetrate the plasma membrane, had the same effect as E2 did, suggesting that a membrane-associated ER mediated the response. In DRG neurons from ERbetaKO mice, E2 attenuated the ATP-induced [Ca2+]i flux as it did in WT mice, but in DRG neurons from ERalphaKO mice, E2 failed to inhibit the ATP-induced [Ca2+]i increase. These results show that mouse DRG neurons express ERs and the rapid attenuation of ATP-induced [Ca2+]i signaling is mediated by membrane-associated ERalpha.

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Effect of esophagus distention on urinary bladder function in rats

Kaddumi

Qnais

Allouh

2011

Neurourology and Urodynamics

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Bladder inflammation and hypogastric neurectomy influence uterine motility in the rat

Cited by 36 publications

References 14 publications

Cross-organ interactions between reproductive, gastrointestinal, and urinary tracts: modulation by estrous stage and involvement of the hypogastric nerve

Cross-organ interactions between reproductive, gastrointestinal, and urinary tracts: modulation by estrous stage and involvement of the hypogastric nerve

Estrogen receptor-α mediates estradiol attenuation of ATP-induced Ca2+ signaling in mouse dorsal root ganglion neurons

Effect of esophagus distention on urinary bladder function in rats

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