2016
DOI: 10.3310/hta20070
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Bladder ultrasonography for diagnosing detrusor overactivity: test accuracy study and economic evaluation

Abstract: BackgroundUrodynamics (UDS) has been considered the gold standard test for detrusor overactivity (DO) in women with an overactive bladder (OAB). Bladder ultrasonography to measure bladder wall thickness (BWT) is less invasive and has been proposed as an alternative test.ObjectivesTo estimate the reliability, reproducibility, accuracy and acceptability of BWT in women with OAB, measured by ultrasonography, in the diagnosis of DO; to explore the role of UDS and its impact on treatment outcomes; and to conduct an… Show more

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Cited by 28 publications
(34 citation statements)
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References 189 publications
(315 reference statements)
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“…The study was prospective, recruited consecutive women presenting with lower urinary tract symptoms and achieved its target sample size. The prevalence of DO in our study was similar to that reported in literature . In our study, ambulatory UDS was offered to the appropriate women whose symptoms of urinary urgency incontinence were not reproduced during the laboratory UDS improving the performance of the reference standard .…”
Section: Discussionsupporting
confidence: 89%
“…The study was prospective, recruited consecutive women presenting with lower urinary tract symptoms and achieved its target sample size. The prevalence of DO in our study was similar to that reported in literature . In our study, ambulatory UDS was offered to the appropriate women whose symptoms of urinary urgency incontinence were not reproduced during the laboratory UDS improving the performance of the reference standard .…”
Section: Discussionsupporting
confidence: 89%
“…The most widely tested urinary marker, nerve growth factor, has demonstrated problems with specificity and reproducibility 170 . The most widely investigated imaging marker, bladder wall thickness, also failed to demonstrate prognostic value when tested in a large trial of implementation 171 . At the present time, the best clinical end points are subjective rather than objective: symptom severity and quality-of-life impact as reported by patients on validated instruments.…”
Section: Discussionmentioning
confidence: 99%
“…In this prospective multicentric study, 687 women were enrolled and underwent PFS and BWT assessment. The ROC curve for BWT showed no evidence of discrimination at any threshold between those with and without DO ( P = 0.25); the AUC was 0.53 (95% CI 0.48‐0.57) . However, the study presented several limitations considering a significant intra‐operator and inter‐operator variability of about 2 mm and that less than 30 patients were evaluated in most of the centers .…”
Section: Discussionmentioning
confidence: 88%
“…At baseline mean BWT value was 5.7 mm (5.6‐5.9); after 6 weeks of treatment a 20% reduction of BWT was recorded (4.6 mm [4.4‐4.8]), then keeping a plateau (4.6 mm [4.4‐4.8]) until the 12th week of treatment . Conversely, the Bladder Ultrasound Study (BUS) Collaborative Group also reported poor outcomes of BWT assessment as an accurate method of DO diagnosis . In this prospective multicentric study, 687 women were enrolled and underwent PFS and BWT assessment.…”
Section: Discussionmentioning
confidence: 99%