Blaise Ketone Synthesis

Abstract

The reaction between an organozinc halide and acyl halide to form ketone is generally known as the Blaise ketone synthesis. Organozinc chloride is known as Blaise reagent, which is formed by the reaction between anhydrous zinc chloride and a Grignard reagent and can be applied directly to the coupling with acyl halide without any isolation. Besides this, the coupling between organozinc chloride and β‐hydroxy carbonyl chloride has also been reported. This reaction has important applications in organic synthesis.