Blastocyst or Blastomycosis?

Walker, Jackson; Biondi, Nicholas; Pivato, Erica; Sharma, Sneha; Phatak, Prajakta; Das, Manisha

doi:10.1016/j.jaccas.2022.09.008

Cited by 2 publications

(5 citation statements)

References 9 publications

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“…Surviving patients with BIE were diagnosed in the 21st century. One received a combination of amphotericin B and itraconazole [ 26 ] and the other, an unnamed antifungal [ 25 ]. Neither required surgery.…”

Section: Discussionmentioning

confidence: 99%

“…Two references described the same case [17,18]. Our final cohort consisted of 11 cases with definite endocardial involvement [17][18][19][20][21][22][23][24][25][26].…”

Section: Methodsmentioning

confidence: 99%

“…Seven cases described positive cardiac histopathologic findings involving the endocardium. In the other four cases, two were managed medically with diagnosis based on echocardiography, histology, and culture growth from other sites of dissemination, followed by regression of cardiac lesions with azole therapy [ 25 , 26 ]. The third patient had recurrent heart failure.…”

Section: Case Presentationmentioning

confidence: 99%

“…Manifestations included intracardiac masses or abscesses involving atria, ventricles, or atrial appendages with epicardial, myocardial, and pericardial involvement. Valvular IE was noted in only three cases: one aortic [ 24 ], one tricuspid [ 26 ], and one unspecified but presumed mitral and/or tricuspid valve given valvular insufficiency [ 21 ]. There were no cases of prosthetic valve endocarditis (PVE).…”

Section: Case Presentationmentioning

confidence: 99%

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Endemic Fungal Infective Endocarditis Caused by Coccidioides, Blastomyces and Histoplasma Species in the United States

Kasule,

Grant,

Apolinario

et al. 2024

Cureus

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We describe a recent case of Coccidioides bioprosthetic aortic valve infective endocarditis successfully managed at our institution. This led us to perform a literature review of endemic fungal infective endocarditis in the United States caused by Coccidioides, Blastomyces, and Histoplasma. Symptoms preceded infective endocarditis diagnosis by several months. Patients with Coccidioides and Blastomyces infective endocarditis were younger with fewer comorbid conditions. Valvular involvement was relatively uncommon in Blastomyces infective endocarditis (27%). Fungemia was noted in patients with infective endocarditis due to Histoplasma (30%) and Coccidioides (18%). Mortality rates for infective endocarditis were high (Histoplasma, 46%; Coccidioides, 58%; Blastomyces, 80%); infective endocarditis was commonly diagnosed post-mortem (Coccidioides, 58%; Blastomyces, 89%). Most surviving patients with infective endocarditis (Histoplasma, 79%; Coccidioides, 80%) underwent valve surgery along with prolonged antifungal therapy. The two surviving patients with Blastomyces infective endocarditis received antifungal therapy without surgery.

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Section: Discussionmentioning

confidence: 99%

“…Two references described the same case [17,18]. Our final cohort consisted of 11 cases with definite endocardial involvement [17][18][19][20][21][22][23][24][25][26].…”

Section: Methodsmentioning

confidence: 99%

Section: Case Presentationmentioning

confidence: 99%

Section: Case Presentationmentioning

confidence: 99%

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Endemic Fungal Infective Endocarditis Caused by Coccidioides, Blastomyces and Histoplasma Species in the United States

Kasule,

Grant,

Apolinario

et al. 2024

Cureus

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“…[ 9 ]. Histoplasma endocarditis has been described the most frequently, with 80 cases [ 10 ], followed by a few reported cases of Coccidiodes and single cases of Paracoccidioides and Sporothrix endocarditis [ 9 , 11 ]. The valve most often affected is the aortic in Histoplasma endocarditis, vs the mitral valve with Coccidioides [ 9 , 11 ].…”

Section: Discussionmentioning

confidence: 99%

Blastomycosis Endocarditis: Case Report and Literature Review

Murillo Chavez,

Filippov,

Licandro

et al. 2023

Open Forum Infectious Diseases

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We report successful treatment of a case of disseminated blastomycosis originating in the right lung, with involvement of the right pleural space, multiple ribs and vertebral bodies, pericardium, and mitral valve endocarditis. The 22-year-old patient presented with a 13-month history of right lower lobe pneumonia associated with fevers, night sweats, rib pain, and 27 kg weight loss. Pathology examination revealed Blastomyces from multiple biopsies of inflammatory masses in the right thorax. After a 4-week induction with liposomal amphotericin followed by oral itraconazole, the patient had complete resolution of the clinical and laboratory findings of blastomycosis.

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Blastocyst or Blastomycosis?

Cited by 2 publications

References 9 publications

Endemic Fungal Infective Endocarditis Caused by Coccidioides, Blastomyces and Histoplasma Species in the United States

Endemic Fungal Infective Endocarditis Caused by Coccidioides, Blastomyces and Histoplasma Species in the United States

Blastomycosis Endocarditis: Case Report and Literature Review

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