Blastomyces dermatitidis in a Renal Transplant Recipient: A Case Report

Salem, M. Ben; Hamouda, M.; Mohamed, M.; Aloui, S.; Letaief, A.; Moussa, Amgad M.; Skhiri, H.; Zakahama, A.; Dhia, N. Ben

doi:10.1016/j.transproceed.2017.06.005

Cited by 8 publications

(8 citation statements)

References 19 publications

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“…The antifungals with the most in vitro potency for the isolates from all 20 cases included voriconazole, posaconazole, itraconazole, amphotericin B, and micafungin [198]. Several cases of cutaneous blastomycosis have been reported in South Africa, Tunisia, and Morocco with no pulmonary involvement [199][200][201][202][203]. B. dermatitidis has been implicated in several cases of pulmonary, subcutaneous, vertebral and paravertebral blastomycosis in Tunisia, Morocco, and Tanzania [194,[204][205][206]].…”

Section: Blastomycosismentioning

confidence: 99%

Invasive Fungal Diseases in Africa: A Critical Literature Review

Bongomin

Ekeng

Kibone

et al. 2022

JoF

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Invasive fungal diseases (IFDs) are of huge concern in resource-limited settings, particularly in Africa, due to the unavailability of diagnostic armamentarium for IFDs, thus making definitive diagnosis challenging. IFDs have non-specific systemic manifestations overlapping with more frequent illnesses, such as tuberculosis, HIV, and HIV-related opportunistic infections and malignancies. Consequently, IFDs are often undiagnosed or misdiagnosed. We critically reviewed the available literature on IFDs in Africa to provide a better understanding of their epidemiology, disease burden to guide future research and interventions. Cryptococcosis is the most encountered IFD in Africa, accounting for most of the HIV-related deaths in sub-Saharan Africa. Invasive aspergillosis, though somewhat underdiagnosed and/or misdiagnosed as tuberculosis, is increasingly being reported with a similar predilection towards people living with HIV. More cases of histoplasmosis are also being reported with recent epidemiological studies, particularly from Western Africa, showing high prevalence rates amongst presumptive tuberculosis patients and patients living with HIV. The burden of pneumocystis pneumonia has reduced significantly probably due to increased uptake of anti-retroviral therapy among people living with HIV both in Africa, and globally. Mucormycosis, talaromycosis, emergomycosis, blastomycosis, and coccidiomycosis have also been reported but with very few studies from the literature. The emergence of resistance to most of the available antifungal drugs in Africa is yet of huge concern as reported in other regions. IFDs in Africa is much more common than it appears and contributes significantly to morbidity and mortality. Huge investment is needed to drive awareness and fungi related research especially in diagnostics and antifungal therapy.

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Section: Blastomycosismentioning

confidence: 99%

Invasive Fungal Diseases in Africa: A Critical Literature Review

Bongomin

Ekeng

Kibone

et al. 2022

JoF

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“…A total of 268 SOT recipients with an endemic mycoses were described in 204 reports [ 4–8 , 13 , 16 , 18 , 20 , 21 , 23 , 25 , 27 , 28 , 33–37 , 40 , 42 , 45 , 46 , 48–52 , 55 , 58–61 , 64–70 , 72–88 , 90–99 , 101–146 , 148–168 , 170–183 , 186 , 188–197 , 207 , 209–244 ]. Table 1 summarizes their characteristics.…”

Section: Resultsmentioning

confidence: 99%

“…Thirty-one cases of blastomycosis were reported [ 7 , 8 , 13 , 20 , 21 , 23 , 35 , 45 , 46 , 48 , 51 , 52 , 55 , 59 , 60 , 64 , 65 , 67 , 68 , 70 , 195 , 209 , 211 , 244 ]. The majority of reports from the United States (10 of 16) were within endemic areas [ 20 , 21 , 35 , 45 , 46 , 51 , 60 , 67 , 195 , 211 ].…”

Section: Resultsmentioning

confidence: 99%

“…The majority of reports from the United States (10 of 16) were within endemic areas [ 20 , 21 , 35 , 45 , 46 , 51 , 60 , 67 , 195 , 211 ]. Eleven [ 8 , 13 , 23 , 35 , 48 , 52 , 64 , 65 , 68 , 70 , 209 ] had documented risk factors for disseminated infection, while this was unknown in 5 cases [ 7 , 55 , 59 , 211 , 244 ]. Five mentioned receipt of antithymocyte globulin [ 23 , 64 , 65 , 209 , 244 ], while 6 reported treatment for acute rejection before disease onset [ 59 , 64 , 65 , 68 , 209 , 244 ].…”

Section: Resultsmentioning

confidence: 99%

“…One patient was treated with methylprednisone for worsening graft function [ 70 ], and another had chronic cellular rejection [ 51 ]. The majority were receiving mycophenolate mofetil (MMF) (19 of 29 [65.5%]) [ 7 , 8 , 13 , 21 , 35 , 45 , 46 , 48 , 55 , 59 , 64 , 65 , 67 , 70 , 244 ].…”

Section: Resultsmentioning

confidence: 99%

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Clinical Characteristics and Outcomes of Endemic Mycoses After Solid Organ Transplantation: A Comprehensive Review

Abad,

Razonable

2024

Open Forum Infectious Diseases

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Background Geographically endemic fungi can cause significant disease among solid organ transplant (SOT) recipients. We provide an update on the epidemiology, clinical presentation and outcomes of 5 endemic mycoses in SOT recipients. Methods Multiple databases were reviewed from inception through May 2023 using key words for endemic fungi (e.g. Coccidioidomycosis or Coccidioides, Histoplasmosis or histoplasma, etc.). We included adult SOT recipients and publications in English or with English translation. Results Among 16 cohort studies that reported on blastomycosis (n=3), coccidioidomycosis (n=5), histoplasmosis (n=4), and various endemic mycoses (n=4), the incidence rates varied: coccidioidomycosis (1.2-5.8%); blastomycosis (0.14-0.99%) and histoplasmosis (0.4-1.1%). There were 204 reports that described 268 unique cases of endemic mycoses, including 172 histoplasmosis, 31 blastomycosis, 34 coccidioidomycosis, 6 paracoccidioidomycosis, and 25 talaromycosis. The majority of patients were male (176/261, 67.4%). Transplanted allografts were mostly kidney (191/268, 71.3%), followed by liver (n=39, 14.6%), heart (n=18, 6.7%), lung (n=13, 4.9%), combined kidney-liver, and kidney-pancreas (n=6, 2.7%). In all five endemic mycoses, most patients presented with fever (162/232, 69.8%) and disseminated disease (179/268, 66.8%). Cytopenias were frequently reported for histoplasmosis (71/91, 78.0%), coccidioidomycosis (8/11, 72.7%) and talaromycosis (7/8, 87.5%). Graft loss was reported in 12/136 patients (8.8%). All-cause mortality was reported in 71/267 (26.6%); half (n=34, 50%) of the deaths were related to the underlying mycoses. Conclusions Endemic mycoses commonly present with fever, cytopenias and disseminated disease in SOT recipients. There is a relatively high rate of all-cause mortality, including many that were attributed to endemic mycoses.

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Mycoses in Transplant

Swaminathan¹

2019

Clinical Practice of Medical Mycology in Asia

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Blastomyces dermatitidis in a Renal Transplant Recipient: A Case Report

Cited by 8 publications

References 19 publications

Invasive Fungal Diseases in Africa: A Critical Literature Review

Invasive Fungal Diseases in Africa: A Critical Literature Review

Clinical Characteristics and Outcomes of Endemic Mycoses After Solid Organ Transplantation: A Comprehensive Review

Mycoses in Transplant

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