Bleeding time and Clotting Time in Healthy Male and Female College Students of Karukutty Village, Kerala

Kumar, Sudhir; Vk, Jm; George, J; Mukkadan, J K

doi:10.3126/hprospect.v12i1.8720

Cited by 7 publications

(9 citation statements)

References 28 publications

(20 reference statements)

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“…These findings confirm those of Ikese et al (2015), who found that a freeze-dried extract of Tridax procumbens significantly decreased bleeding time. The results are also similar to the ethanolic extracts of the same plant that were shown to reduce the bleeding time (Manjusha et al 2014) which reflects platelet function (Kumar et al 2013). This plant has potential activation effects on the platelets.…”

Section: Discussionsupporting

confidence: 79%

“…These are new findings on this plant that have previously not been reported. Bleeding time indicates the platelet function (Kumar et al 2013), and therefore, this plant may have activation effects on the platelets.…”

Section: Discussionmentioning

confidence: 99%

“…Duke's method of bleeding time was used (Janzarik et al 1988). Capillary method of clotting time was used (Kumar et al 2013). Prothrombin time and APTT were done at Kenyatta National Hospital Hematology laboratory.…”

Section: Experimental Protocolmentioning

confidence: 99%

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Investigation of the hemostatic effects of freeze-dried extracts of selected Kenyan plants

Makunyi

2019

Asian J Nat Prod Biochem

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Abstract. Makunyi EG, Bukachi F, Waweru P. 2019. Investigation of the hemostatic effects of freeze-dried extracts of selected Kenyan plants. Biofarmasi J Nat Prod Biochem 17: 39-46. This study aims to investigate the effect and mechanism of action of freeze-dried extracts of Tridax procumbens, Terminalia brownii, Euphorbia tirucalli, and Asphillia africana on hemostasis. Freeze-dried extract of the selected plants was prepared and dose determined for the study. Twelve male New Zealand white rabbits were randomly allocated to two groups (control and test). Blood was collected under standard procedures. Duke's method was used for the bleeding time while the capillary method was used for clotting time. ACL Elitepro machine was used to do prothrombin time and activated partial thromboplastin time. Thromboelastography was done for the most potent extracts. Data were analyzed using independent t-test and results were presented as mean± standard error of means. Differences were considered to be significant if P < 0.05. The results showed that the percentage yield of the extract was; Tridax procumbens (0.8%), Terminalia brownii (0.5%), Euphorbia tirucalli (0.2%) and Aspillia pluriseta (1.3%). Bleeding and clotting time: The bleeding time was reduced by freeze-dried leaf extract of Tridax procumbens (p = 0.0068) and by freeze-dried bark extract of Terminalia brownii (p=0.0068). Freeze-dried leaf extract of Asphillia africana increased the bleeding time (p=0.01). The clotting time was reduced by freeze-dried leaf extract of Tridax procumbens (p = 0.038), the freeze-dried bark extract of Terminalia brownii (p=0.043) and by freeze-dried stem extract of Euphorbia tirucalli (p=0.01). Prothrombin and activated partial thromboplastin time: The prothrombin time was reduced by freeze-dried leaf extract of Tridax procumbens (p = 0.004), the freeze-dried bark extract of Terminalia brownii (p<0.001) and Freeze-dried stem extract of Euphorbia tirucalli (p=0.001). Activated partial thromboplastin time was reduced by freeze-dried leaf extract of Tridax procumbens (p< 0.001), the freeze-dried bark extract of Terminalia brownii (p<0.001) and by freeze-dried stem extract of Euphorbia tirucalli (p<0.001). The results for thromboelastogrpahy showed that four parameters of thromboelastography were tested. Freeze-dried leaf extract of Tridax procumbens reduced the r time (p =0.04), k time (p=0.04) and maximum amplitude (p =0.026) but increased the alpha angle (p =0.01). The freeze-dried bark extract of Terminalia brownii did not have statistically significant differences in thromboelastography variables.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

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Investigation of the hemostatic effects of freeze-dried extracts of selected Kenyan plants

Makunyi

2019

Asian J Nat Prod Biochem

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“…[16] Similar findings of raised BT and CT were seen in females compared to males but was statistically significant in other studies. [17,22,26] There was no such difference in BT, CT gender-wise in study carried out by Mahapatra and Mishra. [20] ||CONCLUSIONS Blood group B is the most common blood group among the students and AB is the least common blood group.…”

Section: |Discussionmentioning

confidence: 84%

Blood group distribution and its relationship with bleeding time and clotting time

Kaur¹,

Singh²,

Bassi³

et al. 2015

Natl J Physiol Pharm Pharmacol

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Background: Blood group plays a vital role in the field of transfusion medicine. The relationship between bleeding time, clotting time, and blood group is important in certain clinical conditions such as epistaxis, surgery, and thrombosis. Researchers have shown that epistaxis is more often encountered in patients having blood group O probably due to lower expression of von Willebrand factor, and elevated levels are a risk factor for thrombosis. Thus, earlier studies found prolonged bleeding and clotting time in individuals with O blood group. Aims and Objectives: The objective of the study was to assess the relationship between bleeding time and clotting time among various blood groups and to identify any gender difference among the same. Materials and Methods: Our study included 150 MBBS students in the age group of 17-20 years. The blood grouping was carried out with the standard antisera, and bleeding time and clotting time were estimated by Duke method and capillary tube method respectively. Finally, bleeding time and clotting time of different blood groups were compared and statistical analysis was carried out. Results: Blood group B (40.7%) was the most common blood group in both genders followed by O (27.3%), A (20.7%), and AB (11.3%). Bleeding time was found to be prolonged 44 min in maximum number of group O (22%) followed by group B (18%), group AB (5.9%), and group A (3.2%) but the difference was statistically insignificant (p = 0.509). Similarly clotting time was 46 min in group B (14.8%) followed by group O (14.6%), group AB (11.76%), and group A (9.7%) but the difference was statistically insignificant (p = 0.885). Gender-wise bleeding time was more prolonged in females (15.7%) than males (13.1%) but the difference was statistically insignificant (p = 0.236), similarly clotting time too was prolonged more in females (16.9%) than males (9.8%) but again the difference was statistically insignificant (p = 0.662). Conclusions: In our study, blood group B predominated followed by O, A, and AB. Bleeding time was prolonged 44 min in blood group O followed by B, AB, and A whereas clotting time was prolonged 46 min in blood group B followed by O, AB, and A. Gender-wise bleeding and clotting time were higher in females than males.

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“…Karbon monoksida adalah gas beracun yang mempunyai afinitas kuat terhadap hemoglobin pada sel darah merah sehingga membentuk karboksi hemoglobin. 5,6 Paparan asap rokok yang dialami terusmenerus pada orang dewasa yang sehat dapat menambah risiko terkena penyakit paru-paru dan penyakit jantung sebesar 20-30 %. 7 Merokok merupakan salah satu faktor yang dapat menyebabkan peningkatan kadar homosistein plasma.…”

Section: Pendahuluanunclassified

Pengaruh merokok terhadap hasil clotting time dan bleeding time pada populasi laki-laki Fakultas Kedokteran UMSU

Ginting

Irma

Arbaningsih

et al. 2019

Sriwijaya Journal of Medicine

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WHO telah menetapkan Indonesia sebagai negara dengan jumlah perokok terbesar ketiga. Ada tiga zat kimia yang paling sangat berbahaya, yaitu tar, nikotin, karbon monoksida yang terkandung dalam rokok. Hasil penelitian di Inggris menunjukkan kepada kita bahwa kurang lebih 50% perokok yang merokok sejak remaja mengalami kematian akibat penyakit yang berhubungan dengan kebiasaan merokok mereka. Penelitian ini bertujuan untuk mengetahui tentang pengaruh asap rokok dengan proses kaskade clotting time. Jenis penelitian ini adalah penelitian analitik dengan menggunakan desain cross-sectional. Penelitian ini menggunakan sampel populasi laki-laki di Fakultas Kedokteran di UMSU yang diwawancara untuk mengetahui bahwa mereka merokok atau tidak, setelah itu, sampel diperiksa clotting time dan bleeding time. Data yang terkumpul dianalisis dengan uji chi-square. Hasil penelitian menunjukkan p = 0,000 bahwa ada hubungan merokok dengan clotting time dan bleeding time pada perokok berat dan sedang. Pada perokok berat dan moderat terdapat hubungan bermakna antara penurunan bleeding time dan peningkatan clotting time dengan merokok. Tidak ada hubungan antara clotting time dan merokok pada perokok ringan.

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Bleeding time and Clotting Time in Healthy Male and Female College Students of Karukutty Village, Kerala

Cited by 7 publications

References 28 publications

Investigation of the hemostatic effects of freeze-dried extracts of selected Kenyan plants

Investigation of the hemostatic effects of freeze-dried extracts of selected Kenyan plants

Blood group distribution and its relationship with bleeding time and clotting time

Pengaruh merokok terhadap hasil clotting time dan bleeding time pada populasi laki-laki Fakultas Kedokteran UMSU

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