Blepharisides A and B, new flavonol glycosides from Blepharis ciliaris growing in Saudi Arabia

Mohamed, Gamal A.; Ibrahim, Sabrin R. M.; Elkhayat, Ehab S.; Ross, Samir A.; Sayed, Hanaa M.; El‐Moghazy, S. A.; El‐Shanawany, Mohamed A.

doi:10.1016/j.phytol.2014.12.018

Cited by 19 publications

(5 citation statements)

References 22 publications

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“…32 Rats were randomly divided into five groups of 6 animals each. The 1st group was given olive oil in an oral dose of 1 mL/kg of body weight (b.wt) for 5 successive days and kept as a negative control.…”

Section: Hepatoprotective Activitymentioning

confidence: 99%

Iridoids and other constituents from Cyperus rotundus L. rhizomes

Mohamed

2015

Bulletin of Faculty of Pharmacy, Cairo University

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On continuation of the phytochemical investigation of the MeOH extract of Cyperus rotundus L. Rhizomes, four compounds namely, methyl 3,4-dihydroxy benzoate (1), ipolamiide (2), 6b-hydroxyipolamiide (3), and rutin (4) were isolated. Their structures were established on the basis of 1D and 2D NMR spectroscopic analyses as well as ESIMS spectral data. Compounds 2 and 3 are reported here for the first time from the genus Cyperus and 1 for the first time from the plant. Co-treatment of CCl 4 hepatic injured rats with the total MeOH extract (TME) and EtOAc fraction significantly restored the hepatic marker enzymes and total bilirubin to near-normal values compared to silymarin (reference drug).ª 2015 Production and hosting by Elsevier B.V. on behalf

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Section: Hepatoprotective Activitymentioning

confidence: 99%

Iridoids and other constituents from Cyperus rotundus L. rhizomes

Mohamed

2015

Bulletin of Faculty of Pharmacy, Cairo University

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“…Antimicrobial [10] and anticancer activities [11] were reported for B. maderaspatensis. Some studies on chemical analysis were reported for plant species from genus Blepharis and various phytochemical compounds were identified, such as stigmasterol tetracosanoate [12] and other flavonol glycosides, and blepharisides A and B [13] from B. ciliaris (L.) B.L.Burtt. As for the plant species B. linariifolia, a few studies have been conducted with respect to its therapeutic properties (for example antioxidant [14,15] and enzymatic inhibitory capacity [15,16]).…”

Section: Introductionmentioning

confidence: 99%

Phenolic Compounds from the Aerial Parts of Blepharis linariifolia Pers. and Their Free Radical Scavenging and Enzyme Inhibitory Activities

et al. 2019

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Background: Blepharis linariifolia Pers. (Family: Acanthaceae) is used in traditional medicines as a general tonic and for the treatment of various health problems in Sudan. The main aim of this study was to isolate and identify the major chemical constituents from the aerial parts of B. linariifolia and evaluate their bioactivities. Methods: The dried aerial parts of the plant were extracted successively with 100% acetone and 50% acetone, and thereafter the combined extract was subjected to repeated column chromatography to isolate the main components. Free radical scavenging activity was evaluated using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical method, and in vitro enzyme inhibitory activities against α-glucosidase, pancreatic lipase, and mushroom tyrosinase were evaluated. Results: From the detailed chemical analysis, verbascoside (1), vanillic acid (2), apigenin (3), and 6″-O-p-coumaroylprunin (4), were isolated and their structures were identified on the basis of their nuclear magnetic resonance (NMR) spectral data. Among the isolated compounds, verbascoside (1) showed the most potent free radical scavenging activity (IC50 = 22.03 ± 0.04 μM). Apigenin (3) and 6″-O-p-coumaroylprunin (4) showed promising inhibitory activities against all tested enzymes. Apigenin (3) showed the most potent inhibitory activity against α-glucosidase and tyrosinase (IC50 = 34.73 ± 1.78 μM and 23.14 ± 1.83 μM, respectively), whereas 6″-O-p-coumaroylprunin (4) showed potent inhibition for lipase (IC50 = 2.25 ± 0.17 μM). Conclusions: Four phenolic compounds were isolated and identified from B. linariifolia acetone extract, which are reported for the first time from this plant. All compounds showed good DPPH free radical scavenging activities, with verbascoside (1) being the most potent. Apigenin (3) was the most active as α-glucosidase and mushroom tyrosinase inhibitor, while 6″-O-p-coumaroylprunin (4) showed potent inhibitory activity for pancreatic lipase.

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“…It was purified on a Sephadex LH‐20 column using MeOH and identified by co‐TLC with an authentic sample using solvent system S 1 . The sugar in the aqueous layer was identified as glucose by co‐PC (paper chromatography) with authentic sugars using solvent system S 3 and aniline phthalate spray reagent .…”

Section: Methodsmentioning

confidence: 99%

Minutaside A, new α‐amylase inhibitor flavonol glucoside from Tagetes minuta: Antidiabetic, antioxidant, and molecular modeling studies

et al. 2015

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. Their structures were established by multiple spectroscopic methods in addition to HRESIMS (high-resolution electrospray ionisation mass spectra) and comparison with literature data. The antioxidant and anti-diabetic activities of the isolated flavonoids were evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and a-amylase inhibition assays. Compounds 1 and 5 showed significant antioxidant activity (84.1 and 83.0% at a 20 mM dose, respectively). Compounds 1, 4, and 5 exhibited strong aamylase inhibitory activity compared with acarbose (a reference a-amylase inhibitor). However, 2 and 3 showed moderate activity. Molecular modeling studies of 1-5 that included docking, flexible alignment, and surface mapping were performed to evaluate their recognition profile aamylase receptor. In docking simulations, 5 displayed a binding mode similar to that of acarbose in the active site of a-amylase enzyme.

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Blepharisides A and B, new flavonol glycosides from Blepharis ciliaris growing in Saudi Arabia

Cited by 19 publications

References 22 publications

Iridoids and other constituents from Cyperus rotundus L. rhizomes

Iridoids and other constituents from Cyperus rotundus L. rhizomes

Phenolic Compounds from the Aerial Parts of Blepharis linariifolia Pers. and Their Free Radical Scavenging and Enzyme Inhibitory Activities

Minutaside A, new α‐amylase inhibitor flavonol glucoside from Tagetes minuta: Antidiabetic, antioxidant, and molecular modeling studies

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