Blepharochalasis with multiple system involvement.

Successful Medical Treatment of Blepharochalasis: A Case Series

“…Compared with the ophthalmology literature, with the usual age of onset in adolescence or early adulthood (Ghose et al, 1984), the onset of symptoms in this case series occured later. The dermatology literature however, more frequently describes a later onset of symptoms, for example in the 1930s, as is the case for most of our patients.…”

Bilateral blepharochalasis

“…Grassegger et al 1 and Schaeppi et al 2 detected IgA deposits in the dermis, while Schaeppi et al also found IgA in the dermo‐epidermal junction. Based on earlier in vitro studies, 7–9 Grassegger et al suggested that during the oedematus episode the change of elastic fibre structure may create neo‐antigen sites in vivo , which then induce an immune response. Schaeppi et al suggested that IgA molecules bind to small proteins – for example, fibronectin and fibulin, which are attached to the elastic fibres and connect these to each other and also to other fibres.…”

Lacrimal gland prolapse in blepharochalasis

“…It has been postulated that blepharochalasis represents a localised form of angioedema 6 although others have suggested that it may be part of a more generalised disorder. 7 Nonsteroidal and other drug-induced urticaria and angioedema should be …”