BLIMP-1: trigger for differentiation of myeloid lineage

Chang, D.; Angelin-Duclos, Cristina; Calame, Kathryn

doi:10.1038/77861

Cited by 137 publications

(142 citation statements)

References 40 publications

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“…PRDM1/Blimp-1 acts as a transcriptional repressor through competitive promoter occupancy (13,19), or by recruiting histone deacetylase activity (20,21) and the histone H3 lysine-9 methyltransferase, G9a (22). In mature tissues, PRDM1/Blimp-1 is additionally expressed in squamous epithelia (23), macrophages (24), and T cells (25)(26)(27). However, targets of PRDM1/Blimp-1 specifically relevant to these lineages are currently undefined.…”

Section: Hc Class II (Mhc-ii)mentioning

confidence: 99%

Repression of IFN-γ Induction of Class II Transactivator: A Role for PRDM1/Blimp-1 in Regulation of Cytokine Signaling

Tooze

Stephenson

Doody

2006

The Journal of Immunology

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MHC class II is expressed in restricted lineages and is modulated in response to pathogens and inflammatory stimuli. This expression is controlled by MHC CIITA, which is transcribed from multiple promoters. Although factors required for induction of CIITA are well characterized, less is known about the mechanisms leading to repression of this gene. During plasma cell differentiation, B lymphocyte-induced maturation protein-1 (PRDM1/Blimp-1) represses promoter (p)III of CIITA, responsible for constitutive expression in B cells. pIV is inducible by IFN-γ in epithelia, macrophages and B cells. An IFN regulatory factor-element (IRF-E) in CIITA-pIV, which is bound by IRF-1 and IRF-2, is necessary for this response. This site matches the PRDM1/Blimp-1 consensus binding site, and PRDM1/Blimp-1 is expressed in cell lineages in which this promoter is operative. We, therefore, investigated whether PRDM1 regulates CIITA-pIV and found that PRDM1 bound to CIITA-pIV in vivo and the IRF-E in vitro. PRDM1 repressed IFN-γ-mediated induction of a CIITA-pIV luciferase reporter in a fashion dependent on an intact consensus sequence and competes with IRF-1/IRF-2 for binding to the IRF-E and promoter activation. In human myeloma cell lines that express IRFs, PRDM1 occupancy of CIITA-pIV was associated with resistance to IFN-γ stimulation, while short interfering RNA knockdown of PRDM1 led to up-regulation of CIITA. Our data indicate that PRDM1 is a repressor of CIITA-pIV, identifying a target of particular relevance to macrophages and epithelia. These findings support a model in which PRDM1/Blimp-1 can modulate the cellular response to IFN-γ by competing with IRF-1/IRF-2 dependent activation of target promoters.

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Section: Hc Class II (Mhc-ii)mentioning

confidence: 99%

Repression of IFN-γ Induction of Class II Transactivator: A Role for PRDM1/Blimp-1 in Regulation of Cytokine Signaling

Tooze

Stephenson

Doody

2006

The Journal of Immunology

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“…BLIMP-1 is a zinc-®nger DNA-binding protein which may contribute to terminal myeloid and Blymphoid di erentiation at least in part by repressing transcription of the c-myc gene (Chang et al, 2000).…”

Section: Myeloid Zinc Finger 1 (Mzf-1)mentioning

confidence: 99%

Transcriptional regulation of granulocyte and monocyte development

2002

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“…Prdm1-induced maturation of lymphocytes is correlated with the ability of Prdm1 to repress numbers of genes critical for mature B cell identity and cellular proliferation [5,[8][9][10][11][12][13]. Prdm1 is also needed for the activation of T cells [14][15][16][17][18], the differentiation of myeloid lineage [19] and the maturation of nature killer (NK) cells [20].…”

Section: Introductionmentioning

confidence: 99%

Identification and expression profiles of prdm1 in medaka Oryzias latipes

et al. 2013

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Mouse Prdm1, also known as Blimp1, plays important roles in maturation and survival of lymphoid cells, as well as in organogenesis of muscle, limb, sensor organs and primordial germ cells. The homologues of mouse prdm1 have been identified in a diverse of animals including zebrafish and fugu. Here, we report the identification and expression profiles of two homologues of prdm1, namely prdm1a and prdm1b in medaka, Oryzias latipes. The transcripts of prdm1a and prdm1b were detectable in all the tissues including immune organs such as gill, spleen, kidney, liver and intestine that we have checked on. The transcripts of prdm1a could be detected in the embryonic shield at mid-gastrula stage and later in the somite, eye, otic vesicle, branchial arches, fin, intestine and cloaca during embryogenesis using in situ hybridization. Moreover, the expression of prdm1a in the liver of both medaka and zebrafish could be up-regulated by the immune stimuli including lipopolysaccharide, polyI:C and the grass carp reovirus, similarly to the up-regulation of IL1B. These results indicate that Prdm1a may play important roles in embryogenesis and also in immune response in fish.

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BLIMP-1: trigger for differentiation of myeloid lineage

Cited by 137 publications

References 40 publications

Repression of IFN-γ Induction of Class II Transactivator: A Role for PRDM1/Blimp-1 in Regulation of Cytokine Signaling

Repression of IFN-γ Induction of Class II Transactivator: A Role for PRDM1/Blimp-1 in Regulation of Cytokine Signaling

Transcriptional regulation of granulocyte and monocyte development

Identification and expression profiles of prdm1 in medaka Oryzias latipes

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