Blinding images to sequence in osteoarthritis: evidence from other diseases

Felson, David T.; Nevitt, M.C.

doi:10.1016/j.joca.2008.09.008

Cited by 56 publications

(52 citation statements)

References 9 publications

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“…The meniscal integrity was assessed on MR images with known time sequence for the reader, which might have created a potential bias. However, it has been shown that the sensitivity of recognizing the relatively minor changes in OA-affected tissues over time is substantially increased if the temporal sequence is known and has been recommended as a preferred approach for longitudinal OA studies (31)(32)(33). We selected OAI study subjects without radiographic knee OA as we were interested in capturing early morphologic changes in the meniscus before radiographic manifestation of OA.…”

Section: Discussionmentioning

confidence: 99%

Natural History of Intrameniscal Signal Intensity on Knee MR Images: Six Years of Data from the Osteoarthritis Initiative

Kumm¹,

Roemer²,

Guermazi³

et al. 2016

Radiology

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Section: Discussionmentioning

confidence: 99%

Natural History of Intrameniscal Signal Intensity on Knee MR Images: Six Years of Data from the Osteoarthritis Initiative

Kumm¹,

Roemer²,

Guermazi³

et al. 2016

Radiology

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“…The filtration was done to remove unnecessary particles and whole content was lyophilised. These aqueous phyto-extracts of combinations were mixed in virgin sesame oil, which was previously extracted at 4ºC from seeds, the oil helps to maintain proper chemical nature of present phytochemicals and this was made a paste by using beehive wax [1][2][3][4][5][6][7][8].…”

Section: Indian Medicinal Plants and Their Phytoconstituents Extractimentioning

confidence: 99%

“…The aim, principles and theories of the treatment protocol was maintained same as the previous study, which the author had already expressed in details [1][2][3][4][5][6][7][8].…”

Section: Aims Principles and Theories For Treatment Protocolmentioning

confidence: 99%

“…It is well established that osteoarthritis (OA) is a painful disease by several researchers and can easily be identified by anatomical measurements, biochemical profiles and radiological images [2][3][4][5][6][7][8][9][10][11]. These diseases are caused by many factors such as ageing, obesity, major injuries, jobs with heavy labour and continuous knee bend posture etc.…”

Section: Introductionmentioning

confidence: 99%

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Normalization of Varus/Valgus Deformities in Osteoarthritis by External Application of Phytoconstituents: Confirmed With Anatomical Observations and Biochemical Profiles and Radiological Images

Ganguly¹

2016

Anat Physiol

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In India, a large number of patients are suffering with genu varum deformities during osteoarthritic (OA) changes in their knee joints. The malaligned knees are either varus (bow-legged) or valgus (knock-kneed) alignment. When the distal part is more medial, it is called varus deformity (≤178º) while the distal part is more lateral, it is called valgus deformity (≥182º). In OA changes of knee-joints, relieving of pain only was achieved temporarily by using medicinal plants based on traditional knowledge. However, correction of malalignment of genu varum by phytotherapeutic protocols has not been attempted as yet.The study was conducted on 196 patients (male: 65 and female: 131) aged ≥ 50 years old for genu varum deformities, normalized by the topical application of phytotherapeutic treatment protocol. To detect the normalization, anatomical measurements and biochemical parameters along with radiological images are being studied before (0 sitting) and after 42 sittings of the treatment. The present results clearly reveal that normalization of genu varum deformities are achieved by topical application of phytoconstituents (aqueous extracts) from acknowledged Indian medicinal plants (Cissus quadrangularis, Heliotropium indicum, Rosmarinus officinalis, Calotropis gigantea) with specialized treatment paradigm, within forty-two sittings.It is a pioneering study for complete recovery of malalignment of genu varum by phytotherapy, which can be an alternative novel method for normalization of genu varum. The present research is corroborated by before and after anatomical observations, biochemical parameters and radiological images.

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“…Временная последо-вательность не является замаскированной, и каждая по-следующая рентгенограмма оценивается в сравнении с первоначальной. Как известно, это повышает чувстви-тельность и воспроизводимость оценок [30][31][32].…”

Section: данные анамнеза Xunclassified

Efficacy and safety of oral strontium ranelate for the treatment of knee osteoarthritis: rationale and design of randomised, double-blind, placebo-controlled trial

Cooper

Reginster

Chapurlat

et al. 2012

Current Medical Research and Opinion

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Blinding images to sequence in osteoarthritis: evidence from other diseases

Cited by 56 publications

References 9 publications

Natural History of Intrameniscal Signal Intensity on Knee MR Images: Six Years of Data from the Osteoarthritis Initiative

Natural History of Intrameniscal Signal Intensity on Knee MR Images: Six Years of Data from the Osteoarthritis Initiative

Normalization of Varus/Valgus Deformities in Osteoarthritis by External Application of Phytoconstituents: Confirmed With Anatomical Observations and Biochemical Profiles and Radiological Images

Efficacy and safety of oral strontium ranelate for the treatment of knee osteoarthritis: rationale and design of randomised, double-blind, placebo-controlled trial

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