Blister and bite cells in G6PD deficiency

Opsahl, Madeleine; Chen, Weina

doi:10.1111/ijlh.13689

Cited by 5 publications

(2 citation statements)

References 2 publications

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“…They are a hallmark of hemoglobinopathies such as thalassemia and Hb C, Hb D, and Hb E as well as liver illness (especially obstructive liver disease), post-splenectomy situations, and obstructive liver disease [30]. Bite cells (degmacytes) or blister cells are produced by phagocytes that have retrieved stiff precipitates of hemoglobin that have been denatured (Heinz bodies); these damaged cells may be the first sign of hemolytic anemia induced by oxidant sensitivity, such as a shortage of glucose-6-phosphate dehydrogenase (G6PD) [31].…”

Section: Shape Variabilitymentioning

confidence: 99%

Untitled

2023

IJCMCR

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The peripheral blood picture (PBP) is a diagnostic procedure that involves smearing peripheral blood cells on a slide for cytology. No matter how elementary, PBP is incredibly useful in characterizing a variety of clinical disorders. This article emphasizes the essential scientific and aesthetic foundation of the PBP. However, this work goes into detail on its clinical traits, laboratory uses, and interpretations of various clinical pathologies. The PBP remained a valuable diagnostic test in hematology despite the developments of digital PBP and genetic methods. The hematologist should ensure a high-quality smear, a comprehensive examination, and proper interpretation in respect of the patient's clinical condition. The examiner's expertise and training level have a significant impact on the reliability of the results.

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Section: Shape Variabilitymentioning

confidence: 99%

Untitled

2023

IJCMCR

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“…Therefore, this case emphasizes the importance of a careful review of blood film morphology (typical morphological changes of erythrocytes during acute hemolytic episode) will be helpful to detect this G6PD deficiency disease. 1…”

Section: Author Contributionsmentioning

confidence: 99%