Synchro-modal supply chain eco-NET (SYNCHRO-NET) is a Horizon 2020 European research project aimed at overcoming the stress due to the increasing transportation distances, the higher complexity, and the vulnerability of international supply chains. In order to foster sustainability, quality, and reliability of such supply chains, SYNCHRO-NET mainly exploits the impact and the possible benefits coming from slow/smart-steaming and synchro-modality transportation strategies, and the related business models. The aim of this paper is to summarize and disseminate the main developments and scientific contributions coming from the project. In particular, the working core of the SYNCHRO-NET solution is an integrated and cloud-based eco-system of optimization and simulation software modules that supports stakeholders’ decisions in freight transportation and logistics management at strategic, operational, and real-time levels. The platform has achieved a high grade of automation in several processes to overcome all the issues related to human-based operations. The efficiency and effectiveness of the overall platform have been tested on three case studies considering pan-European and regional trade lanes, as well as commercial activities between the Far East and European ports. The project results and outputs also allow us to analyze barriers and opportunities of the approach, industrial and academic developments, and relations with emerging technologies.