Utilizing the fundamental characteristics of the decentralization, immutability, and transparency of blockchain technology, the healthcare industry has made notable advancements in incorporating it over the past five years. This review examines the progress and challenges encountered in this critical study by assessing 124 articles published by MDPI between 2018 and the current date. Examining blockchain’s potential uses, like safe data exchange and interoperability in supply chain management and electronic health records, provides exciting new directions for the future of healthcare. Blockchain technology can greatly increase efficiency and cost-effectiveness by guaranteeing data integrity, protecting patient privacy, and reducing administrative procedures. This paper objectively evaluates blockchain’s advancement in healthcare through a thorough analysis of real-world applications and research projects. By highlighting both its advantages and disadvantages, this analysis seeks to add to the continuing conversation about how blockchain will influence the way healthcare is managed and delivered in the future.