Blocking Lipid Uptake Pathways Does not Prevent Toxicity in Adipose Triglyceride Lipase (ATGL) Deficiency

Oluwadare, Jide; Cabodevilla, Ainara G; Son, Ni-Huiping; Hu, Yixin; Mullick, Adam E.; Verano, Michael; Alemán, José O.; Ramasamy, Ravichandran; Goldberg, Ira J.

doi:10.1016/j.jlr.2022.100274

Cited by 5 publications

(2 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although humans also develop a cardiomyopathy with ATGL deficiency [62], the most dramatic symptoms in these patients are pain and weakness associated with skeletal muscle breakdown; circulating levels of the muscle enzyme creatine kinase are increased 10-fold [63 ▪ ]. A recent study attempted unsuccessfully to alleviate the cardiomyopathy due to ATGL deficiency by deletion of LPL or CD36 [64 ▪ ]. In agreement with these observations, ATGL-deficient cardiomyocytes develop LDs from de-novo fatty acid synthesis when grown in lipid-depleted media.…”

Section: Lipid Droplet Degradationmentioning

confidence: 99%

Intracellular lipase and regulation of the lipid droplet

Cabodevilla,

Son,

Goldberg

2024

Current Opinion in Lipidology

Self Cite

View full text Add to dashboard Cite

Purpose of review Lipid droplets are increasingly recognized as distinct intracellular organelles that have functions exclusive to the storage of energetic lipids. Lipid droplets modulate macrophage inflammatory phenotype, control the availability of energy for muscle function, store excess lipid, sequester toxic lipids, modulate mitochondrial activity, and allow transfer of fatty acids between tissues. Recent findings There have been several major advances in our understanding of the formation, dissolution, and function of this organelle during the past two years. These include new information on movement and partition of amphipathic proteins between the cytosol and lipid droplet surface, molecular determinants of lipid droplet formation, and pathways leading to lipid droplet hydrophobic lipid formation. Rapid advances in mitochondrial biology have also begun to define differences in their function and partnering with lipid droplets to modulate lipid storage versus oxidation. Summary This relationship of lipid droplets biology and cellular function provides new understanding of an important cellular organelle that influences muscle function, adipose lipid storage, and diseases of lipotoxicity.

show abstract

Section: Lipid Droplet Degradationmentioning

confidence: 99%

Intracellular lipase and regulation of the lipid droplet

Cabodevilla,

Son,

Goldberg

2024

Current Opinion in Lipidology

Self Cite

View full text Add to dashboard Cite

show abstract

“…A family of proteins named perilipin (PLINs) is involved in lipid uptake, coating, and addressing LDs inside cells (Frank et al, 2015;Najt et al, 2022). Perilipin 1 was the first perilipin described (Greenberg et al, 1991) and after its discovery, the study of LDs, their lipidomic and proteomics, and the role of LDs in health and disease have increased dramatically, expanding the LD biology field (Kobayashi et al, 2008;Kuerschner et al, 2008;Garcıá-Arcos et al, 2010;Turchetto-Zolet et al, 2011;Hsieh et al, 2012;Lin et al, 2014;Markgraf et al, 2014;Kamili et al, 2015;Li et al, 2015;Viktorova et al, 2018;Freyre et al, 2019;Guyard et al, 2022;Kim et al, 2022;Oluwadare et al, 2022).…”

Section: Lipid Metabolismmentioning

confidence: 99%

Cell lipid biology in infections: an overview

Prado,

Camara,

Barbosa

2023

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

Lipids are a big family of molecules with a vast number of functions in the cell membranes, within the cytoplasm, and extracellularly. Lipid droplets (LDs) are the most common storage organelles and are present in almost every tissue type in the body. They also have structural functions serving as building blocks of cellular membranes and may be precursors of other molecules such as hormones, and lipoproteins, and as messengers in signal transduction. Fatty acids (FAs), such as sterol esters and triacylglycerols, are stored in LDs and are used in β-oxidation as fuel for tricarboxylic acid cycle (TCA) and adenosine triphosphate (ATP) generation. FA uptake and entrance in the cytoplasm are mediated by membrane receptors. After a cytoplasmic round of α- and β-oxidation, FAs are guided into the mitochondrial matrix by the L-carnitine shuttle system, where they are fully metabolized, and enter the TCA cycle. Pathogen infections may lead to impaired lipid metabolism, usage of membrane phospholipids, and LD accumulation in the cytoplasm of infected cells. Otherwise, bacterial pathogens may use lipid metabolism as a carbon source, thus altering the reactions and leading to cellular and organelles malfunctioning. This review aims to describe cellular lipid metabolism and alterations that occur upon infections.

show abstract

Exploring the mechanism of Ling-Gui-Zhu-Gan decoction in metabolic cardiomyopathy via inhibiting ferroptosis

Zhao,

Ding,

et al. 2024

Phytomedicine

View full text Add to dashboard Cite

Blocking Lipid Uptake Pathways Does not Prevent Toxicity in Adipose Triglyceride Lipase (ATGL) Deficiency

Cited by 5 publications

References 53 publications

Intracellular lipase and regulation of the lipid droplet

Intracellular lipase and regulation of the lipid droplet

Cell lipid biology in infections: an overview

Exploring the mechanism of Ling-Gui-Zhu-Gan decoction in metabolic cardiomyopathy via inhibiting ferroptosis

Contact Info

Product

Resources

About