Blocking of STAT3 activation by miR-491, acting via EGFR, is involved in metastasis of hepatocellular carcinoma cells through inhibiting cancer stem cell-like properties

Abstract

ABSTRACTwere blocked by up-regulation of STAT3 levels. These results indicate that miR-491 influences CSC-like properties and metastasis of HCC cells by blocking the activation of STAT3 via EGFR, which provides a mechanism for preventing metastasis of HCCs.