Blood 5-hydroxytryptamine levels in the newborn.

Hazra, Monica; Benson, Sheila Maureen; Sandler, M.

doi:10.1136/adc.40.213.513

Cited by 11 publications

(4 citation statements)

References 17 publications

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“…The platelet 5-HT ontogeny results are in good agreement with the limited prior reports of levels in newborns and infants, both in terms of the absolute levels observed and the apparent early low levels (32)(33)(34)(35)(36). Although most previous studies have reported 5-HT concentrations in units of ng/mL, the tendency for ng/mL values to positively correlate with platelet count, observed here and elsewhere (37) 420 platelets unit of concentration is preferred and a greater effort should be made to use this form of expression.…”

Section: Discussionsupporting

confidence: 80%

Platelet Serotonin in Newborns and Infants: Ontogeny, Heritability, and Effect of In Utero Exposure to Selective Serotonin Reuptake Inhibitors

et al. 2004

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Ontogeny of platelet serotonin (5-hydroxytryptamine, 5-HT) during the first year of life was examined in newborns and infants. The effects of in utero exposure to selective serotonin reuptake inhibitors (SSRI, including fluoxetine, sertraline, and citalopram) were examined by comparing cord blood 5-HT levels in exposed and unexposed newborns. Heritability was assessed by correlation of the platelet 5-HT values observed for mother-infant pairs. No age effect was observed in 1-49 wk-old infants (r ϭ 0.13, p ϭ 0.49) and mean platelet 5-HT levels in infants (241 Ϯ 102 ng/mL, n ϭ 33; 615 Ϯ 320 ng/10 9 platelets, n ϭ 32) were similar to those reported for older children and adults. However, significantly lower blood 5-HT levels were observed in newborns (81.3 Ϯ 32.5 ng/mL, n ϭ 16, p Ͻ 0.0001; 297 Ϯ 101 ng/10 9 platelets, n ϭ 11, p ϭ 0.0007) compared with the 1-49 wk-old infants. The mean cord blood 5-HT concentrations in newborns exposed in utero to SSRI (n ϭ 8) were substantially lower than that seen in unexposed (n ϭ 16) newborns (20.6 Ϯ 14.4 versus. 81.3 Ϯ 32.5 ng/mL, p ϭ 0.0001; 90.7 Ϯ 55.4 versus. 297 Ϯ 101 ng/10 9 platelets, p ϭ 0.0005). Platelet serotonin levels (ng/10 9 platelets) in mother-child pairs (n ϭ 32) were significantly correlated (r ϭ 0.415, p ϭ 0.018). The results indicate that, although platelet 5-HT is low at birth, values quickly increase and stabilize at near-adult levels by 1 mo of age. Gestational exposure to SSRI appears to substantially reduce platelet 5-HT uptake in the fetus, strongly suggesting that such exposure has important physiologic effects. The observed mother-infant correlation agrees with a previous report of high heritability in a large adult population. There is a continuing interest in platelet serotonin (5-HT) due to its hemostatic, thrombogenic, and cardiovascular effects (1, 2), its utility in assessing the bioeffects of SSRI (3-5), and its alteration in several neuropsychiatric disorders (6 -8). In prior work (9 -11), we carried out a series of studies examining the effects of SSRI exposure on platelet 5-HT in nursing infants and in the present study seek to extend the available data regarding the normal ontogeny of platelet 5-HT in infants. We also wished to establish more firmly prior reports of low platelet 5-HT levels in newborn cord blood and to examine the effects of gestational SSRI exposure on cord blood levels.Finally, our investigations of nursing mother-infant pairs provided the opportunity to contribute to the limited data assessing the heritability of platelet 5-HT.The platelet and neuronal 5-HT transporters are encoded by the same gene and appear identical in terms of pharmacology (12, 13). All platelet 5-HT is accumulated by uptake through the platelet membrane 5-HT transporter and a number of studies have used the decline in platelet 5-HT seen after administration of reuptake inhibitors as an index of central and peripheral transporter blockade (3-5). The impact of central serotonin 5-HT modulation by SSRI during critical periods of brain development is un...

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Section: Discussionsupporting

confidence: 80%

Platelet Serotonin in Newborns and Infants: Ontogeny, Heritability, and Effect of In Utero Exposure to Selective Serotonin Reuptake Inhibitors

et al. 2004

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“…The concentration of this amine was very close to that found in the neonatal period by Berman et al (1965) and Hazra et al (1965).…”

Section: Discussionsupporting

confidence: 56%

Serotonin Metabolism in Normal and Abnormal Infants during the Perinatal Period

Tu¹,

Wong²

1976

Neonatology

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The concentration of serotonin (5-HT) and 5-hydroxyindole acetic acid (5-HIAA) in various body fluids was measured during the perinatal period in two groups of infants born with normal and pathological conditions, respectively. Evidence was obtained showing that fetal blood 5-HT level was relatively stable, uninfluenced by maternal or fetal factors, and was about half the value of the maternal blood. High levels of 5-HIAA and evidence of an active decomposition of 5-HT were found in the amniotic fluid. These findings suggest that 5-HT in utero is subjected to a very active metabolic turnover. The origin of the fetal blood 5-HT and the significance of the placenta in the control of intrauterine 5-HT metabolism is discussed. There was no clear evidence of abnormal 5-HT metabolism in toxemic pregnancies, premature babies, and an infant with Down’s syndrome in the perinatal period.

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“…1 and the Table. The value of this ratio is high in early infancy, falling to a lower level at 1 year. The high initial value of the ratio is due to an increased rate of 5HIAA excretion in early infancy and coincides with the rising levels of whole blood 5HT occurring during this period (Hazra, Benson, and Sandler, 1965). The subsequent decrease in ratio is not due to an absolute decrease in 5HIAA excretion, but to a reduced increment rate, accompanied by a constantly increasing creatinine excretion rate.…”

Section: Resultsmentioning

confidence: 72%