Blood advanced glycation end products and biomarkers of inflammation in class III obese Brazilian subjects

Silva, Thiago Lenoir da; Linhares, Rose Marie Muller; Remor, Aline Pertile; Ghisoni, Karina; Martins, Roberta de Paula; Poli, Anicleto; Aguiar, Aderbal S.; Ronsoni, Marcelo Fernando; Hohl, Alexandre; Walz, Roger; Latini, Alexandra

doi:10.15761/iod.1000174

Cited by 3 publications

(1 citation statement)

References 24 publications

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“…Regarding HbA1c and AGEs, a study indicated that HbA1c level was positively and significantly correlated with blood AGEs in obese Brazilian subjects [63]. Gestational weight gain and average third trimester HbA1c level (>5%) were found as risk factors for neonatal complications in mothers with GDM [64].…”

Section: Plos Onementioning

confidence: 99%

The relationship between advanced glycation end products and gestational diabetes: A systematic review and meta-analysis

et al. 2020

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Introduction Gestational Diabetes Mellitus (GDM) is a condition in which women without history of diabetes experience hyperglycemia during pregnancy, especially at the second and third trimesters. In women who have had GDM, an elevated body mass index (BMI) may have a substantial impact for persistent hyperglycemia in their lives after gestation. Beyond hyperglycemia, increased local oxidative stress directly promotes the formation of Advanced Glycation End-products (AGEs). Hence, this systematic review and meta-analysis was aimed to determine the relationship between the level of AGEs and/or related metabolic biomarkers with GDM. Methods Literature search was carried out through visiting electronic databases, indexing services, and directories including PubMed/MEDLINE (Ovid ®), EMBASE (Ovid ®), google scholar and WorldCat to retrieve studies without time limit. Following screening and eligibility evaluation, relevant data were extracted from included studies and analyzed using Rev-Man 5.3 and STATA 15.0. Inverse variance method with random effects pooling model was used for the analysis of outcome measures at 95% confidence interval. Hedge's adjusted g statistics was applied to calculate the standardized mean difference (SMD) to consider the small sample bias. Besides, meta-regression, meta-influence, and publication bias analyses were conducted. The protocol has been registered on PROSPERO with ID: CRD42020173867. Results A total of 16 original studies were included for the systematic review and meta-analysis.

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Section: Plos Onementioning

confidence: 99%

The relationship between advanced glycation end products and gestational diabetes: A systematic review and meta-analysis

et al. 2020

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Chronic Metabolic Derangement-Induced Cognitive Deficits and Neurotoxicity Are Associated with REST Inactivation

et al. 2018

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Chronic metabolic alterations may represent a risk factor for the development of cognitive impairment, dementia, or neurodegenerative diseases. Hyperglycemia and obesity are known to imprint epigenetic markers that compromise the proper expression of cell survival genes. Here, we showed that chronic hyperglycemia (60 days) induced by a single intraperitoneal injection of streptozotocin compromised cognition by reducing hippocampal ERK signaling and by inducing neurotoxicity in rats. The mechanisms appear to be linked to reduced active DNA demethylation and diminished expression of the neuroprotective transcription factor REST. The impact of the relationship between adiposity and DNA hypermethylation on REST expression was also demonstrated in peripheral blood mononuclear cells in obese children with reduced levels of blood ascorbate. The reversible nature of epigenetic modifications and the cognitive impairment reported in obese children, adolescents, and adults suggest that the correction of the anthropometry and the peripheral metabolic alterations would protect brain homeostasis and reduce the risk of developing neurodegenerative diseases.

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Pain hypersensitivity and increased urinary tetrahydrobiopterin levels in mice submitted to high fat diet

Eichwald,

Barros,

Solano

et al. 2024

Preprint

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Objective: This study aimed to examine the impact of high-fat diet (HFD)-induced obesity on pain sensitivity and tetrahydrobiopterin (BH4) levels. The effect of moderate-intensity physical exercise, an anti-inflammatory non-pharmacological intervention, on pain scores was also investigated. Methods: Adult male C57BL/J6 mice were fed standard or HFD for eight weeks. Total body weight, food intake, locomotor and motivational behavior and pain reflexes were measured. A subgroup of animals underwent physical exercise for five days per week over six weeks. Blood was collected for glucose tolerance testing and levels of lactate. Urine samples were collected to measure BH4 levels. Results: We showed that HFD increased weight gain, visceral white adipose tissue, and the percentage of body fat. These anthropometric alterations were characterized by impaired glucose tolerance at four and eight weeks of the dietary intervention. It was also observed reduced locomotor activity and higher pain scores in HFD-fed mice that were prevented by the physical exercise intervention. HFD also induced the increase of urinary BH4 levels at four and eight weeks of intervention. Conclusion: Urinary BH4 can be proposed as a potential easy-to-access, sensitive and reliable biomarker of pain development, and a promising target for the control of pain hypersensitivity in obesity.

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Blood advanced glycation end products and biomarkers of inflammation in class III obese Brazilian subjects

Cited by 3 publications

References 24 publications

The relationship between advanced glycation end products and gestational diabetes: A systematic review and meta-analysis

The relationship between advanced glycation end products and gestational diabetes: A systematic review and meta-analysis

Chronic Metabolic Derangement-Induced Cognitive Deficits and Neurotoxicity Are Associated with REST Inactivation

Pain hypersensitivity and increased urinary tetrahydrobiopterin levels in mice submitted to high fat diet

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