Blood-Based Biomarkers Could Help Identify Subclinical Brain Damage Caused by Arterial Hypertension

doi:10.37757/mr2016.v18.n1-2.9

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“…When applied seeking for cerebrovascular risk prediction, the results are not so clear; and although more severe asymptomatic brain lesions were associated with middle-high CV risk, a considerable number of individuals classifying as LR, actually exhibited substantial evidence of subclinical CSVD. Thus, for individuals with LR, especially if they suffer from arterial hypertension, screening methods for asymptomatic CSVD at primary settings need to be developed, in order to establish more personalised attention to avoid serious neurological complications 36 37…”

Section: Discussionmentioning

confidence: 99%

Asymptomatic cerebral small vessel disease in adults with low cardiovascular risk

et al. 2023

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IntroductionCerebral small vessel disease (CSVD) frequently occurs in individuals with vascular risk factors. This condition might go unrecognised or result in only mild functional deficits.ObjectiveTo evaluate the relationship between cardiovascular (CV) risk calculated with the HEARTS app and CSVD burden in a population without cardio-cerebrovascular diseases, and to estimate the prevalence of CSVD in low risk (LR) individuals.MethodsAsymptomatic subjects with vascular risk factors were included from primary health areas in Havana. The WHO’s revised CV disease risk prediction chart (HEARTS app) was applied to all individuals, who were classified into two groups: LR and moderate/high risk (M/HR). Brain MRI was performed in all subjects.Results170 patients were included: 43 (25.3%) classified as low CV risk and 127 (74.7%) had M/HR CV risk. Half of the neurologically healthy individuals included displayed cerebral small vessel involvement (51.2%). White matter hyperintensities (WMH) and enlarged perivascular spaces were the most frequent lesions observed in both groups. WMH were more severe and more severe global score for CSVD were more frequent in the M/HR group (57.5%). It was noteworthy that 32.6% of LR-patients also exhibited more severe CSVD. The multivariate regression analysis revealed an independent association of arterial hypertension and age with the severity of CSVD.ConclusionsCV risk stratification through the HEARTS app has limited utility for predicting brain health in individuals with low CV risk. Identifying silent CSVD in individuals with apparently low CV risk is important, especially if they suffer from arterial hypertension.

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Section: Discussionmentioning

confidence: 99%

Asymptomatic cerebral small vessel disease in adults with low cardiovascular risk

et al. 2023

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Blood-Based Biomarkers Could Help Identify Subclinical Brain Damage Caused by Arterial Hypertension

Abstract: Peer ReviewedFigura 1: Daño detectado en órgano diana en 34 pacientes hipertensos asintomáticos Riñón 0% Riñón Corazón 0% Cerebro Riñón 23.1%

Cited by 1 publication

References 65 publications

Asymptomatic cerebral small vessel disease in adults with low cardiovascular risk

Asymptomatic cerebral small vessel disease in adults with low cardiovascular risk

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