Blood cell diagnostics by a chip lensless microscope

Riesenberg, Rainer; Kanka, Mario; Mayer, Günter

doi:10.1117/12.2037563

Cited by 2 publications

(1 citation statement)

References 24 publications

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“…Based on the granularity and size, cells can be counted and a 3-part differential can be obtained. RBC have also been analyzed in a similar system [18]. However, despite the potential advantages of a label-free approach, the performance of these systems compared to gold standards is not very satisfactory.…”

Section: Cell Countingmentioning

confidence: 99%

Development of inexpensive blood imaging systems: where are we now?

Chu

Smith

Wachsmann‐Hogiu

2015

Expert Review of Medical Devices

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Clinical applications in the developing world, such as malaria and anemia diagnosis, demand a change in the medical paradigm of expensive care given in central locations by highly trained professionals. There has been a recent explosion in optical technologies entering the consumer market through the widespread adoption of smartphones and LEDs. This technology commoditization has enabled the development of small, portable optical imaging systems at an unprecedentedly low cost. Here, we review the state-of-the-field of the application of these systems for low-cost blood imaging with an emphasis on cellular imaging systems. In addition to some promising results addressing specific clinical issues, an overview of the technology landscape is provided. We also discuss several key issues that need to be addressed before these technologies can be commercialized.

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Section: Cell Countingmentioning

confidence: 99%

Development of inexpensive blood imaging systems: where are we now?

Chu

Smith

Wachsmann‐Hogiu

2015

Expert Review of Medical Devices

View full text Add to dashboard Cite

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Imaging of Live Cells by Digital Holographic Microscopy

Mihaylova

2024

Photonics

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Imaging of microscopic objects is of fundamental importance, especially in life sciences. Recent fast progress in electronic detection and control, numerical computation, and digital image processing, has been crucial in advancing modern microscopy. Digital holography is a new field in three-dimensional imaging. Digital reconstruction of a hologram offers the remarkable capability to refocus at different depths inside a transparent or semi-transparent object. Thus, this technique is very suitable for biological cell studies in vivo and could have many biomedical and biological applications. A comprehensive review of the research carried out in the area of digital holographic microscopy (DHM) for live-cell imaging is presented. The novel microscopic technique is non-destructive and label-free and offers unmatched imaging capabilities for biological and bio-medical applications. It is also suitable for imaging and modelling of key metabolic processes in living cells, microbial communities or multicellular plant tissues. Live-cell imaging by DHM allows investigation of the dynamic processes underlying the function and morphology of cells. Future applications of DHM can include real-time cell monitoring in response to clinically relevant compounds. The effect of drugs on migration, proliferation, and apoptosis of abnormal cells is an emerging field of this novel microscopic technique.

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Blood cell diagnostics by a chip lensless microscope

Cited by 2 publications

References 24 publications

Development of inexpensive blood imaging systems: where are we now?

Development of inexpensive blood imaging systems: where are we now?

Imaging of Live Cells by Digital Holographic Microscopy

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