Blood clinicopathological differences between type I and II ketosis in dairy cows

Xu, Chuang; Shen, Taiyu; Yao, Yuan; Yu, Hao; Xia, Cheng; Zhang, Hongyou

doi:10.18805/ijar.7495

Cited by 6 publications

(6 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The results of our study contrast with those of others report that a period of major fluctuations in serum Ca 2+ occurs between day 7 prepartum (168 hours before calving) and day 7 postpartum (168 hours after calving) and that, as the number of calvings or age increases, cow serum concentrations of Ca 2+ decrease, and incidence of clinical hypocalcemia increases (Samad et al 2002;Meléndez et al 2004) and can cause other associated metabolic disorders (Chapinal et al 2011;Salgado et al 2009;Chuang et al 2016).…”

Section: Resultscontrasting

confidence: 99%

“…Ketosis has a higher incidence in cows that have had two or more calvings and at the beginning of lactation when milk production is higher (Espino et al 2005;Enjalbert et al 2001;Gilliund et al 2001;Ingvartsen et al 2003;Overton et al 2004). The dairy cow induced ketosis when the concentration of NEFA product more than the demands of body (Chuang et al 2016) Some breeds of dairy cattle, such as Jersey and Guernsey have a high propensity to contract metabolic disorders because they produce colostrum with a higher concentration of Ca 2+ than Holstein cows and because the 1.25 (OH) 2 D 3 receptors are fewer in Jersey cows (Ingvartsen et al 2003;Andresen , 2001). In general, the diseases that occur at a subclinical stage are of great importance in the dairy industry because of economic and health consequences (Suthar et al 2013).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Calcium and b-hydroxybutyrate serum concentrations in early postpartum of Jersey cows

Domínguez-Mancera

Pinos-Rodríguez

Juárez-Lagunes

et al. 2019

IJAR

View full text Add to dashboard Cite

The experiment was conducted to determine serum [Ca2+], â-hydroxybutyrate in blood, milk and urine during peripartum and urinary pH. Ninety Jersey cows were selected during their last month of pregnancy. Five days before calving, at calving and 12, 24, 48 and 72 h after calving blood samples were taken. Ca2+, and â-hydroxybutyrate (â-HB) in blood serum, milk and urine were determined. Correlations and one-way ANOVA were used for the analyses. Calcium and glucose (mmolL-1) decreased throughout the peripartum: Ca2+ [2.65 to 2.31±0.11 (p less than 0.05)]; glucose [3.74 to 3.11±0.26 (p le3ss than 0.05)]. NEFA, blood â-HB, urine â-HB and milk â-HB (mmolL-1) increased over time: NEFA [0.36 to 0.45±0.05 (p less than 0.05)]; blood â-HB [0.69 to 1.29±0.07 (p less than 0.05)]; urine â-HB [0.10 to 0.37±0.09 p less than 0.05)]; milk â-HB [0.09 to 0.18±0.04 p less than 0.05)]. Urine pH did not change: 7.31 to 6.95±0.34 (p>0.05). No correlation was found between b-HB in blood and b-HB in milk. b-HB in blood and milk did not have a functional relationship in Jersey cows that was useful in diagnosing metabolic disorders.

show abstract

Section: Resultscontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Calcium and b-hydroxybutyrate serum concentrations in early postpartum of Jersey cows

Domínguez-Mancera

Pinos-Rodríguez

Juárez-Lagunes

et al. 2019

IJAR

View full text Add to dashboard Cite

show abstract

“…In the present study, we found that the serum levels of NEFA, glucose, and insulin were increased in HYK cows at the calving date. In line with our findings, previous studies also reported that increased NEFA levels in HYK dairy cows were accompanied by an increased BHB concentration ( 19 , 44 ). In a poor adaptation state, abundant NEFA are released from the adipose tissue, and further metabolized to TG or BHB in the liver ( 13 ).…”

Section: Discussionsupporting

confidence: 93%

Alterations in the gut microbiota and its metabolites contribute to metabolic maladaptation in dairy cows during the development of hyperketonemia

Luo,

Du,

Huang

et al. 2024

mSystems

View full text Add to dashboard Cite

Metabolic maladaptation in dairy cows after calving can lead to long-term elevation of ketones, such as β-hydroxybutyrate (BHB), representing the condition known as hyperketonemia, which greatly influences the health and production performance of cows during the lactation period. Although the gut microbiota is known to alter in dairy cows with hyperketonemia, the association of microbial metabolites with development of hyperketonemia remains unknown. In this study, we performed a multi-omics analysis to investigate the associations between fecal microbial community, fecal/plasma metabolites, and serum markers in hyperketonemic dairy cows during the transition period. Dynamic changes in the abundance of the phyla Verrucomicrobiota and Proteobacteria were detected in the gut microbiota of dairy cows, representing an adaptation to enhanced lipolysis and abnormal glucose metabolism after calving. Random forest and univariate analyses indicated that Frisingicoccus is a key bacterial genus in the gut of cows during the development of hyperketonemia, and its abundance was positively correlated with circulating branched-chain amino acid levels and the ketogenesis pathway. Taurodeoxycholic acid, belonging to the microbial metabolite, was strongly correlated with an increase in blood BHB level, and the levels of other secondary bile acid in the feces and plasma were altered in dairy cows prior to the diagnosis of hyperketonemia, which link the gut microbiota and hyperketonemia. Our results suggest that alterations in the gut microbiota and its metabolites contribute to excessive lipolysis and insulin insensitivity during the development of hyperketonemia, providing fundamental knowledge about manipulation of gut microbiome to improve metabolic adaptability in transition dairy cows. IMPORTANCE Accumulating evidence is pointing to an important association between gut microbiota-derived metabolites and metabolic disorders in humans and animals; however, this association in dairy cows from late gestation to early lactation is poorly understood. To address this gap, we integrated longitudinal gut microbial (feces) and metabolic (feces and plasma) profiles to characterize the phenotypic differences between healthy and hyperketonemic dairy cows from late gestation to early lactation. Our results demonstrate that cows underwent excessive lipid mobilization and insulin insensitivity before hyperketonemia was evident. The bile acids are functional readouts that link gut microbiota and host phenotypes in the development of hyperketonemia. Thus, this work provides new insight into the mechanisms involved in metabolic adaptation during the transition period to adjust to the high energy and metabolic demands after calving and during lactation, which can offer new strategies for livestock management involving intervention of the gut microbiome to facilitate metabolic adaptation.

show abstract

“…A positive correlation was found between BHB values and hepatocyte functional status parameters (bilirubin, AST, GGT) and a negative correlation with TGC (Djoković et al, 2019a). Chuang et al (2016) found differences in the values of individual laboratory parameters in cows with ketosis type 1 and type 2 measured from the moment of calving to the fourth week of lactation and showed a significant deviation of the AST value. Based on the results obtained by González et al (2011), the activity of AST ˃100 IU/L may indicate some degree of liver damage most likely as a consequence of fatty infiltration.…”

Section: Figures 1-4 Regression Line Of Multiple Linear Analysis For Predicting Blood Bhb In Cowsmentioning

confidence: 74%

Multiparametric analysis of blood parameters and hyperketonemia in cows

Cincović¹,

Delić-Vujanović²,

Đoković³

et al. 2021

Acta agriculturae Serbica

View full text Add to dashboard Cite

The aim of this study is to examine the interrelationships and importance of biochemical and endocrine blood parameters in the assessment of beta-hydroxybutyrate (BHB) values in healthy and ketotic cows using multiparameter statistics. The experiment included 45 Holstein Friesian cows (22 healthy and 23 with ketosis). The criterion used for detecting ketosis was the value of BHB ˃1.2 mmol/L. Based on laboratory indicators, cows were precisely classified into two large clusters: a cluster of healthy cows and a cluster of cows suffering from ketosis with minimal mixing of individual cows between clusters. Metabolic parameters were divided into two large clusters: parameters whose values increased in ketosis and decreased in healthy animals and parameters whose values decreased in ketosis and increased in healthy individuals. In ketotic cows there was a higher expression of non-esterified fatty acids, total bilirubin, aspartate aminotransferase, insulin and growth hormone, and a lower expression of glucose, albumin, triglycerides, cholesterol and total lipids compared to the healthy group. In 3 cows with ketosis, greater metabolic similarity with healthy cows was found, because of the absence of pronounced changes in the concentration of hormones and glucose. Thyroxine and triiodothyronine showed either increased or decreased expression in ketotic cows. In cows with lower values of these hormones, there were more pronounced metabolic changes characteristic of ketosis. For the development of metabolic adaptations to ketosis, in addition to hyperketonemia, there must be endocrine changes and changes in glycemia.

show abstract

Blood clinicopathological differences between type I and II ketosis in dairy cows

Cited by 6 publications

References 23 publications

Calcium and b-hydroxybutyrate serum concentrations in early postpartum of Jersey cows

Calcium and b-hydroxybutyrate serum concentrations in early postpartum of Jersey cows

Alterations in the gut microbiota and its metabolites contribute to metabolic maladaptation in dairy cows during the development of hyperketonemia

Multiparametric analysis of blood parameters and hyperketonemia in cows

Contact Info

Product

Resources

About