Blood eosinophil level to predict chronic obstructive pulmonary disease clinical outcomes

Cai, Chengsen; Wang, Jun

doi:10.1097/cm9.0000000000000447

Cited by 2 publications

(3 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results revealed that there were insignificant impacts of both high blood eosinophil level and ICS use, on both readmission and mortality rate. A recent study [21] included 493 cases with COPD reporting that patients with lower eosinophil counts experienced poorer clinical outcomes, and eosinophil levels may be a helpful marker to predict outcomes in AECOPD. The better outcome be related to a better response to systemic steroids in the eosinophilic group [22].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Blood and sputum eosinophilia in COPD exacerbation

Helala

AbdelFattah

Elsalam³

2022

Egypt J Bronchol

View full text Add to dashboard Cite

Background Exacerbations in chronic obstructive pulmonary disease (COPD) are major contributors to worsening lung function, impaired quality of life, emergency healthcare use, and COPD-related mortality. COPD exacerbations are heterogeneous in terms of airway inflammation and etiology. Objectives To assess the relation between blood and sputum eosinophils and COPD exacerbation. Subjects and methods Prospective cohort study, conducted on 100 COPD patients presented in outpatient clinic. All patients were subjected to medical history including: occupational history, smoking history, comorbidity, number of exacerbations in last year and their degree, history of admission in the last year and treatment taken for COPD. Modified Medical Research Council scale of dyspnea, peak expiratory flow rate, oxygen saturation using pulse oximetry. Complete blood count with differential eosinophilic count. Sputum sample differential cell count was done. Results The eosinophil level in blood before and after treatment showed a significant positive correlation with the number of hospital admission in the last year (r = 0.29; P = 0.003 and r = 0.3; P = 0.002, respectively). Regarding the eosinophil level either in blood or in sputum, it showed significant statistical elevation in patients not using steroid treatment in comparison to patients who used systemic or inhaled steroid treatments (P < 0.001 and 0.004, respectively). Conclusion Blood eosinophil count can be used as a severity marker of COPD exacerbations. The eosinophil levels, either in blood or sputum, were significantly correlated with the degree of exacerbation. Sputum eosinophilia can also predict the risk of hospitalization. In addition, blood eosinophil count can direct the use of oral corticosteroids in exacerbation.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Cai and Wang [21] concluded that eosinophils as a blood marker of COPD remain controversial and more basic and systematic experiments are needed to clarify the pathogenesis of blood eosinophils in patients with COPD to better serve the clinic in the future.…”

Section: Discussionmentioning

confidence: 99%

Blood and sputum eosinophilia in COPD exacerbation

Helala

AbdelFattah

Elsalam³

2022

Egypt J Bronchol

View full text Add to dashboard Cite

show abstract

“…In addition, the thresholds matter. Different studies set different thresholds and cutoff values within their own groups as subscribed before [ 19 ]. Thus, the capacity of patients was categorized according to different strata, which will surely lead to variability in the results.…”

Section: Thresholdsmentioning

confidence: 99%

Factors Influencing the Stability of Blood Eosinophils Counts in Chronic Obstructive Pulmonary Disease Patients

Cai

Wang

2022

Canadian Respiratory Journal

Self Cite

View full text Add to dashboard Cite

Blood eosinophil (EOS) has recently been recognized as a biomarker for chronic obstructive pulmonary disease (COPD) patients. However, few studies have concentrated on the stability of blood eosinophil counts (BEC), and those studies have produced varying results. With further research, we have found minor drawbacks and vulnerabilities that lead to the variability of the results. This paper enumerates several areas of relevant research with varying conclusions to further investigate the stability of BEC in COPD patients.

show abstract

Blood eosinophil level to predict chronic obstructive pulmonary disease clinical outcomes

Cited by 2 publications

References 18 publications

Blood and sputum eosinophilia in COPD exacerbation

Blood and sputum eosinophilia in COPD exacerbation

Factors Influencing the Stability of Blood Eosinophils Counts in Chronic Obstructive Pulmonary Disease Patients

Contact Info

Product

Resources

About