Blood flow-improving activity of methyl jasmonate-treated adventitious roots of mountain ginseng

Abstract

Ginsenosides from Panax ginseng are well known for their diverse pharmacological effects including antithrombotic activity. Since adventitious roots of mountain ginseng (ARMG) also contain various ginsenosides, blood flow-improving effects of the dried powder and extract of ARMG were investigated. Rats were orally administered with dried powder (PARMG) or ethanol extract (EARMG) of ARMG (125, 250 or 500 mg/kg) or aspirin (30 mg/kg, a reference control) for 3 weeks. Forty min after the final administration, carotid arterial thrombosis was induced by applying a 70% FeCl3-soaked filter paper outside the arterial wall for 5 min, and the blood flow was monitored with a laser Doppler probe. Both PARMG and EARMG delayed the FeCl3-induced arterial occlusion in a dose-dependent manner, doubling the occlusion time at high doses. In mechanism studies, a high concentration of EARMG inhibited platelet aggregation induced by collagen in vitro. In addition, EARMG improved the blood lipid profiles, decreasing triglyceride and cholesterol levels. Although additional action mechanisms remain to be clarified, it is suggested that ARMG containing high amount of ginsenosides such as Rg3 improves blood flow not only by inhibiting oxidative thrombosis, but also by modifying blood lipid profiles.

Therapeutic Potential of Ginsenosides as an Adjuvant Treatment for Diabetes

“…Hemodynamics and pulmonary circulation parameters, such as cardiac index, intracavitary blood volume, and central venous pressure, significantly improved (Sun et al, 2015 ). In addition, a wide range of pharmacological activities have been reported for ginsenosides, including anti-aging (Hu et al, 2015 ), immunoregulation (Yang et al, 2017 ), neuroregulation (Wang et al, 2016b ), lipid regulation (Huang et al, 2017b ), antithrombosis (Ban et al, 2017 ), and wound healing (Li et al, 2017 ).…”