Blood Flow, Pressure and Compliance in the Male Human Bladder

Kershen, Richard T.; Azadzoi, Kazem M.; Siroky, Mike B.

doi:10.1097/00005392-200207000-00027

Cited by 46 publications

(73 citation statements)

References 28 publications

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“…LUTS were classified according to the IPSS as minimal (score 0-7), moderate (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19) and severe ( > 20). The duration of LUTS was also recorded .…”

Section: Methodsmentioning

confidence: 99%

“…However, in vitro models were developed, and strips of detrusor smooth muscle used to investigate how BOO affects detrusor physiology [9]. Recently, with the use of laser Doppler ultrasonography (US), bladder blood flow was found to decrease during the later stages of filling, along with the increase in intravesical pressure [11]. Thus we investigated the tissue distribution of ischaemia in human detrusor of patients with BOO, and correlated the results with clinical variables.…”

Section: Introductionmentioning

confidence: 99%

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Immunohistochemical estimation of hypoxia in human obstructed bladder and correlation with clinical variables

Koritsiadis¹,

Stravodimos²,

Koutalellis³

et al. 2008

BJU International

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OBJECTIVETo investigate the tissue distribution of ischaemia in human detrusor in patients with bladder outlet obstruction (BOO) and to correlate the results with clinical variables, as clinical BOO is a common problem in ageing men and ischaemia might be important in detrusor dysfunction.PATIENTS AND METHODSFrom September 2004 to October 2006, 70 patients were recruited, comprising 60 scheduled for surgery to treat benign prostatic hyperplasia (the study group) and 10 as controls. Detrusor tissue was retrieved and stained for hypoxia‐inducible factor (HIF)‐1α, a cellular marker of hypoxia.RESULTSThe mean (sd) total number of cells immunoreactive to HIF‐1α in the study group was 93.3 (48.09), and in the specimens from the control group only few rare cells showed weak immunoreactivity to HIF‐1α (0–2). Positive cells were in different proportions between muscle bundles and submucosa, expressed mainly in stromal cells. The urothelium and detrusor muscle showed no immunoreactivity to HIF‐1α. There was strong immunoreactivity in patients with prolonged BOO (<10 years), declining thereafter, and in those patients with urinary retention.CONCLUSIONSThe urothelium and detrusor seem to be more resistant to hypoxic stress, while stromal cells perceive low oxygen tension. The bladder response to chronic hypoxia through HIF‐1α expression is limited in time and might depend on the functional status of the detrusor.

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“…LUTS were classified according to the IPSS as minimal (score 0-7), moderate (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19) and severe ( > 20). The duration of LUTS was also recorded .…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Immunohistochemical estimation of hypoxia in human obstructed bladder and correlation with clinical variables

Koritsiadis¹,

Stravodimos²,

Koutalellis³

et al. 2008

BJU International

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show abstract

“…When filled with fluid, the distended bladder can enlarge to 15 times its decompressed volume, 33,34 reaching a capacity of approximately 400 cc or more. 35 Visually, distention leads to an apparent thinning of the layers.…”

Section: 31mentioning

confidence: 99%

Three-dimensional, distendable bladder phantom for optical coherence tomography and white light cystoscopy

et al. 2014

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Abstract. We describe a combination of fabrication techniques and a general process to construct a threedimensional (3-D) phantom that mimics the size, macroscale structure, microscale surface topology, subsurface microstructure, optical properties, and functional characteristics of a cancerous bladder. The phantom also includes features that are recognizable in white light (i.e., the visual appearance of blood vessels), making it suitable to emulate the bladder for emerging white light þ optical coherence tomography (OCT) cystoscopies and other endoscopic procedures of large, irregularly shaped organs. The fabrication process has broad applicability and can be generalized to OCT phantoms for other tissue types or phantoms for other imaging modalities. To this end, we also enumerate the nuances of applying known fabrication techniques (e.g., spin coating) to contexts (e.g., nonplanar, 3-D shapes) that are essential to establish their generalizability and limitations. We anticipate that this phantom will be immediately useful to evaluate innovative OCT systems and software being developed for longitudinal bladder surveillance and early cancer detection. © The Authors.Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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“…Greenland Je et al [33] and Kershen et al [34] studied in pig and human respectively and concluded that blood flow in bladder reduces with distension that leads to detrusor ischemia and its impaired function. It has been shown in animal model that after reliving the obstruction, these changes are reversible as muscle mass returns to near normal, sensation and compliance improves and bladder capacity decreases.…”

Section: Neurological Diseasementioning

confidence: 99%

“…Many studies reveal that the duration of symptoms has adverse effect on bladder function as the long term bladder distension leads to irreversible ultrastructural changes in detrusor muscle and bladder wall but at what time period these irreversible changes occur, it is not clearly defined. Kershen RT [34] and Ohnishi N et al [37] postulated that long term distension of bladder leads to DM ischemia which leads to decrease bladder contractility and impaired bladder emptying causing CUR.…”

Section: Neurological Diseasementioning

confidence: 99%

Does Temporary Catheter Drainage of Urine Improves Detrusor Function in Chronic Urinary Retention in Patients with Bladder Outlet Obstruction.

Pal¹

2017

UNOAJ

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Chronic urinary retention (CUR) is one of the consequences of bladder outlet obstruction (BOO) that occurs due to impaired functions of detrusor muscles secondary to obstruction related changes in the bladder wall. The effect of catheter drainage (CD) on detrusor function in CUR in animals is well studied but in humans there are very few studies to see its effect in CUR. Material and methods:This is a non-randomized, retrospective study wherein case records of 50 eligible patients attending the Department of Urology during January 2010 to March 2012 were evaluated for CUR. Two UDS, performed 6-12 weeks (average 9 weeks) apart and the parameters which were evaluated were bladder sensation, capacity and voiding detrusor pressure. These parameters were also evaluated against the age of the patient, duration of symptoms and the amount of urine drained on catheterization. Results:The commonest symptoms observed were decrease flows of urine, frequency, straining and incomplete emptying. Bladder function improvement after CD was observed to be maximum in patients with following characteristics: age at presentation in the range of > 60 to < 70 years, duration of lower urinary tract symptoms (LUTS) less than 5 years and amount of urine drained at the time of catheterization being < 500 ml. Conclusion:CUR secondary to BOO is a common problem in elderly males. UDS is the "gold standard" for its evaluation and helps to plan further management. CD of urine is an effective mode of temporary management in patients of CUR secondary to BOO as it provides rest to the detrusor muscle in humans.

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Blood Flow, Pressure and Compliance in the Male Human Bladder

Cited by 46 publications

References 28 publications

Immunohistochemical estimation of hypoxia in human obstructed bladder and correlation with clinical variables

Immunohistochemical estimation of hypoxia in human obstructed bladder and correlation with clinical variables

Three-dimensional, distendable bladder phantom for optical coherence tomography and white light cystoscopy

Does Temporary Catheter Drainage of Urine Improves Detrusor Function in Chronic Urinary Retention in Patients with Bladder Outlet Obstruction.

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