Blood flow restriction training: You can occlude your veins, but not your oxygen transport

Kambič, Tim

doi:10.1113/jp279936

Cited by 1 publication

(3 citation statements)

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“…Three of the 7 studies of BFRE in HD were RCTs ( Kambic et al, 2019 ; Kambic, 2020 ; Ogawa et al, 2021 ) and the other 4 studies were pre-post studies without control groups. All of the 7 studies examined the effects of resistance BFRE and all were performed without report of adverse events and also observed significant improvements in several of the MHCHF components ( Table 4 ).…”

Section: Resultsmentioning

confidence: 99%

“…The results of the acute and chronic BFRE studies in HD are also important since plasma fibrinogen and fibrin degradation products were unchanged and after plasma volume correction, the D-dimer and CRP values were no longer statistically different than before BFR exercise highlighting the potential safety of BFRE in patients with HD. ( Madarame et al, 2013 ; Kambič, 2020 ). Furthermore, 38% of the patient population in the Ogawa et al study had atrial fibrillation which has been a potential concern when considering BFRE in patients with HD and HF.…”

Section: Discussionmentioning

confidence: 99%

“…In fact, cyclic occlusion and reperfusion via BFRE may promote favorable acute and chronic effects on cardiac and cardiovascular performance in hypertensive subjects and patients with HD and HF. ( Shweiki et al, 1992 ; Higashi and Yoshizumi, 2004 ; Takano et al, 2005 ; Horiuchi and Okita, 2012 ; Pinto and Polito, 2016 ; May et al, 2017 ; Crisafulli et al, 2018 ; Pinto et al, 2018 ; Wong et al, 2018 ; Christiansen et al, 2019 ; Silva et al, 2019 ; Christiansen et al, 2020 ; Kambič, 2020 ; Liu et al, 2021 ; Wong et al, 2021 ; Li et al, 2022 ). Thus, personalized BFRE has the potential to improve skeletal muscle and cardiovascular performance of patients with HD and HF which may subsequently improve many of the MHCHF components and attenuate its viscous cycle.…”

Section: Introductionmentioning

confidence: 99%

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Beneficial Role of Blood Flow Restriction Exercise in Heart Disease and Heart Failure Using the Muscle Hypothesis of Chronic Heart Failure and a Growing Literature

Cahalin

Formiga

Owens³

et al. 2022

Front. Physiol.

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Background: Blood flow restriction exercise (BFRE) has become a common method to increase skeletal muscle strength and hypertrophy for individuals with a variety of conditions. A substantial literature of BFRE in older adults exists in which significant gains in strength and functional performance have been observed without report of adverse events. Research examining the effects of BFRE in heart disease (HD) and heart failure (HF) appears to be increasing for which reason the Muscle Hypothesis of Chronic Heart Failure (MHCHF) will be used to fully elucidate the effects BFRE may have in patients with HD and HF highlighted in the MHCHF.Methods: A comprehensive literature review was performed in PubMed and the Cochrane library through February 2022. Inclusion criteria were: 1) the study was original research conducted in human subjects older than 18 years of age and diagnosed with either HD or HF, 2) study participants performed BFRE, and 3) post-intervention outcome measures of cardiovascular function, physical performance, skeletal muscle function and structure, and/or systemic biomarkers were provided. Exclusion criteria included review articles and articles on viewpoints and opinions of BFRE, book chapters, theses, dissertations, and case study articles.Results: Seven BFRE studies in HD and two BFRE studies in HF were found of which four of the HD and the two HF studies examined a variety of measures reflected within the MHCHF over a period of 8–24 weeks. No adverse events were reported in any of the studies and significant improvements in skeletal muscle strength, endurance, and work as well as cardiorespiratory performance, mitochondrial function, exercise tolerance, functional performance, immune humoral function, and possibly cardiac performance were observed in one or more of the reviewed studies.Conclusion: In view of the above systematic review, BFRE has been performed safely with no report of adverse event in patients with a variety of different types of HD and in patients with HF. The components of the MHCHF that can be potentially improved with BFRE include left ventricular dysfunction, inflammatory markers, inactivity, a catabolic state, skeletal and possibly respiratory muscle myopathy, dyspnea and fatigue, ANS activity, and peripheral blood flow. Furthermore, investigation of feasibility, acceptability, adherence, adverse effects, and symptoms during and after BFRE is needed since very few studies have examined these important issues comprehensively in patients with HD and HF.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%