Blood Flow Simulations for the Design of Stented Valve Reducer in Enlarged Ventricular Outflow Tracts

Caiazzo, Alfonso; Guibert, Romain; Boudjemline, Younès; Vignon-Clémentel, Irène

doi:10.1007/s13239-015-0240-z

Cited by 15 publications

(4 citation statements)

References 35 publications

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“…This causes blood flow regurgitation in the RV during diastole, leading to progressive enlargement of the RV and pulmonary arteries. Valve replacement is, thus, often warranted at some point in the disease progression [ 38 ]. The RV overload needs to be mimicked in order to establish an easily reproducible porcine model of repaired TOF.…”

Section: Pigsmentioning

confidence: 99%

Large Mammalian Animal Models of Heart Disease

Camacho

Fan

Liu

et al. 2016

JCDD

183

185

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Due to the biological complexity of the cardiovascular system, the animal model is an urgent pre-clinical need to advance our knowledge of cardiovascular disease and to explore new drugs to repair the damaged heart. Ideally, a model system should be inexpensive, easily manipulated, reproducible, a biological representative of human disease, and ethically sound. Although a larger animal model is more expensive and difficult to manipulate, its genetic, structural, functional, and even disease similarities to humans make it an ideal model to first consider. This review presents the commonly-used large animals—dog, sheep, pig, and non-human primates—while the less-used other large animals—cows, horses—are excluded. The review attempts to introduce unique points for each species regarding its biological property, degrees of susceptibility to develop certain types of heart diseases, and methodology of induced conditions. For example, dogs barely develop myocardial infarction, while dilated cardiomyopathy is developed quite often. Based on the similarities of each species to the human, the model selection may first consider non-human primates—pig, sheep, then dog—but it also depends on other factors, for example, purposes, funding, ethics, and policy. We hope this review can serve as a basic outline of large animal models for cardiovascular researchers and clinicians.

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Section: Pigsmentioning

confidence: 99%

Large Mammalian Animal Models of Heart Disease

Camacho

Fan

Liu

et al. 2016

JCDD

183

185

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“…within the entire geometry. The technique has gained significant attention in the last few years to investigate the influence of disturbed hemodynamics on cardiovascular diseases (Caiazzo et al, ; Nguyen et al, ; Doost et al, ). These patient‐specific models contributed to the clinical decision making of physicians.…”

Section: Introductionmentioning

confidence: 99%

Heart function and hemodynamic analysis for zebrafish embryos

Yalcin

Amindari

Butcher

et al. 2017

Developmental Dynamics

142

100

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The Zebrafish has emerged to become a powerful vertebrate animal model for cardiovascular research in recent years. Its advantages include easy genetic manipulation, transparency, small size, low cost, and the ability to survive without active circulation at early stages of development. Sequencing the whole genome and identifying ortholog genes with human genome made it possible to induce clinically relevant cardiovascular defects via genetic approaches. Heart function and disturbed hemodynamics need to be assessed in a reliable manner for these disease models in order to reveal the mechanobiology of induced defects. This effort requires precise determination of blood flow patterns as well as hemodynamic stress (i.e., wall shear stress and pressure) levels within the developing heart. While traditional approach involves time-lapse brightfield microscopy to track cell and tissue movements, in more recent studies fast light-sheet fluorescent microscopes are utilized for that purpose. Integration of more complicated techniques like particle image velocimetry and computational fluid dynamics modeling for hemodynamic analysis holds a great promise to the advancement of the Zebrafish studies. Here, we discuss the latest developments in heart function and hemodynamic analysis for Zebrafish embryos and conclude with our future perspective on dynamic analysis of the Zebrafish cardiovascular system. Developmental Dynamics 246:868-880, 2017. V C 2017 Wiley Periodicals, Inc.

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“…All these PPVI related adverse events have been studied and assessed using FE models (29,30). The methodology has been used not only to support PPVI planning in specific patients, but also to study PPVI stent mechanical behaviour, design new devices and enhance safety in the compassionate use of prototype devices (8,(31)(32)(33).…”

Section: Computational Modellingmentioning

confidence: 99%

3D Printing and Engineering Tools Relevant to Plan a Transcatheter Procedure

Milano

Popa

Iacob

et al. 2021

Cardiac Catheterization for Congenital Heart Disease

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Advance cardiac imaging techniques such as three-dimensional (3D) printing technology and engineering tools have experienced a rapid development over the last decade in many surgical and interventional settings. In presence of complex cardiac and extra-cardiac anatomies, the creation of a physical, patient-specific model is useful to better understand the anatomical spatial relationships and formulate the best surgical or interventional plan. Although many case reports and small series have been published over this topic, at the present time, there is still a lack of strong scientific evidence of the benefit of 3D models and advance engineering tools, including virtual and augmented reality, in clinical practice and only qualitative evaluation of the models has been used to investigate their clinical use.Patient specific 3D models can be printed in many different materials including rigid, flexible and transparent materials, depending on their application. To plan interventional procedure, transparent materials may be preferred in order to better evaluate the device or stent landing zone. 3D models can also be used as an input for augmented and virtual reality application and advance fluido-dynamic simulation, which aim to support the interventional cardiologist before entering the cath-lab.The aim of this chapter is to present an overview on how 3D printing, extended reality platforms and the most common computational engineering methodologiesfinite element and computational fluid dynamicsare currently used to support percutaneous procedures in congenital heart disease (CHD), with examples from the scientific literature.

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Blood Flow Simulations for the Design of Stented Valve Reducer in Enlarged Ventricular Outflow Tracts

Cited by 15 publications

References 35 publications

Large Mammalian Animal Models of Heart Disease

Large Mammalian Animal Models of Heart Disease

Heart function and hemodynamic analysis for zebrafish embryos

3D Printing and Engineering Tools Relevant to Plan a Transcatheter Procedure

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