Blood Mercury, Arsenic, Cadmium, and Lead in Children with Autism Spectrum Disorder

Li, Huamei; Li, Hui; Li, Yun; Liu, Yujie; Zhao, Zhengyan

doi:10.1007/s12011-017-1002-6

Cited by 58 publications

(42 citation statements)

References 40 publications

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“…Many of the studies have significant methodological limitations, and in ASD children certain genetic and toxic environmental factors may have a synergic influence at critical stages of neurodevelopment. Although there are positive associations between ASD and heavy metal exposures in the environment, these authors cannot draw firm conclusions on causation [9].…”

Section: Discussionmentioning

confidence: 98%

“…Positive associations were found between levels of Hg and seafood. Similarly, Li H et al [9] have investigated whether blood levels of Hg and other heavy metals in ASD children significantly differ from those of age-and sex-matched controls. The results of these studies could support a key role for heavy metal exposure, namely Hg, in the genesis of ASD symptoms.…”

Section: Discussionmentioning

confidence: 99%

“…Statistically significant correlations between increased Hg concentrations in hair and increased ASD severity have been also revealed [7]. Concentrations of blood and of urine along with hair could serve in the prediction of possible health effects as outcomes of the different forms of exposure to Hg as in ASD [8][9][10][11]. Thus the aim of the present study was to assess mercury levels in hair and urinary excretion levels of children with primary or idiopathic ASD and in healthy children of similar age.…”

Section: Introductionmentioning

confidence: 96%

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Neurotoxicity by mercury is not associated with autism spectrum disorders in Spanish children

et al. 2020

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Background: The pathophysiological etiologies related with the development of Autism Spectrum Disorders (ASD) remain controversial. Different authors have studied neurotoxins such as mercury (Hg) and their relationship with ADS. The objective of this study was to assess the levels of Hg in hair in a group of ASD children (chronic exposure) and in urinary excretion (acute exposure), in comparison to a healthy group. Methods: A case-control study was conducted in Spanish children. We compared 54 ASD children (aged 2-6) with no other associated pathology to a normally-developing control group (54 subjects). Results: There were no differences in urine (p:0.631) and hair (p:1.000) samples percentages below the limits of detection between the control and the ASD groups, and also between patients in the regression ASD subgroup (AMR) (p:0.08) and the non-regression ASD subgroup (ANMR) (p:0.705). When the analysis was adjusted for age and sex, the differences between Hg levels maintained not significant. There were no correlations between Hg concentrations in the ASD group as a whole (p: 0.739), or when they were subdivided into ASD-AMR (p: 0.739) and ASD-ANMR (p: 0.363). Conclusions: The present study shows no evidence in our geographical area to support an association between mercury neurotoxicity and the etiopathogenesis of ASD.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

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Neurotoxicity by mercury is not associated with autism spectrum disorders in Spanish children

et al. 2020

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“…To give an example, Pb impairs intellectual development, causes behavioral disorders and motor hyperactivity. It can also have adverse effects on the health of children, causing behavioral and neurological problems, and a reduction in IQ scores [1,5,6,[8][9][10][11]. Similar effects can be observed in the case of As.…”

Section: Introductionmentioning

confidence: 92%

“…Studies indicate the neurotoxic effect of numerous substances, including heavy metals (on mitosis, cell differentiation, synapse formation, oxidative stress, endoplasmic reticulum stress, and essential metalloprotein disruption, apoptotic processes, level of neurotransmitters). Lead (Pb) and arsenic (As) are well-established neurotoxicants known to cross the blood-brain barrier and affect neurodevelopment [1,[5][6][7]. To give an example, Pb impairs intellectual development, causes behavioral disorders and motor hyperactivity.…”

Section: Introductionmentioning

confidence: 99%

Analysis of lead, arsenic and calcium content in the hair of children with autism spectrum disorder

Fiłon

Ustymowicz-Farbiszewska

Krajewska-Kułak

2020

BMC Public Health

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Background: Explanation of the pathogenesis and treatment of autism spectrum disorders (ASD) is one of the most significant challenges for scientists today. It is believed that a major pathogenetic factor of this condition is epigenetic changes caused by environmental factors, including toxic metals (cadmium (Cd), lead (Pb), mercury (Hg), aluminium (Al), and arsenic (As)). The nervous system may also be affected by deficiencies of both micro-and macroelements (e.g. calcium (Ca), zinc (Zn)). The aim of the study was to analyze the concentrations of Pb, As, and Ca in the hair of children with ASD and a control group. Methods: The materials for the study comprised hair samples collected from 30 children diagnosed with ASD (case group) and 30 children randomly selected from the general population of Bialystok and surrounding region (control group). Concentrations of Pb, As, and Ca were tested with electron microscopy scanning method. Next, the content of the analyzed elements in the hair was assessed as well as their impact on autism development in the children and the mutual interactions between them. The obtained results were statistically analyzed with Statistica PL 12.5., using the Mann-Whitney U test, and Spearman correlation coefficient. Results: Mean Ca level in the hair of the case group was lower than the mean level of this element in the control group. Mean As and Pb concentration in the hair of children with ASD was statistically significantly higher than the mean concentration of this element in the hair of children without neurological disorders. Statistically insignificant weak positive correlations between Ca and As content and negative between Ca and Pb in the hair of children from the case group were noted. Also, statistically significant mean positive correlations between Pb and As were observed. Conclusions: In this small study, according to the observations, children diagnosed with ASD suffer from Ca deficiency and toxic metal overload (As and Pb). These abnormalities may play the main role, as an environmental factor, in the pathogenesis of the analyzed disorder.

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Cellular and Neurological Effects of Lead (Pb) Toxicity

Gudadhe,

Singh,

Ahsan

2024

Environmental Contamination Remediation and Management

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Blood Mercury, Arsenic, Cadmium, and Lead in Children with Autism Spectrum Disorder

Cited by 58 publications

References 40 publications

Neurotoxicity by mercury is not associated with autism spectrum disorders in Spanish children

Neurotoxicity by mercury is not associated with autism spectrum disorders in Spanish children

Analysis of lead, arsenic and calcium content in the hair of children with autism spectrum disorder

Cellular and Neurological Effects of Lead (Pb) Toxicity

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