Blood Metallothionein Transcript as a Biomarker for Metal Sensitivity: Low Blood Metallothionein Transcripts in Arsenicosis Patients from Guizhou, China

Liu, Jie; Cheng, Min-Liang; Yang, Qin; Shan, Ke-ren; Shen, Jun; Zhou, Yuepeng; Zhang, Xinjiang; Dill, Anna L.; Waalkes, Michael P.

doi:10.1289/ehp.10035

Cited by 66 publications

(44 citation statements)

References 38 publications

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“…Notwithstanding those similarities, some Franciscana dolphins presented MT levels outside of the range, mainly in kidney of juveniles and adults. Similar situations were reported in pinnipeds (Sonne et al, 2009) and humans (Allan et al, 2000;Liu et al, 2007;Wu et al, 2000).…”

Section: Discussionsupporting

confidence: 77%

Metallothioneins pattern during ontogeny of coastal dolphin, Pontoporia blainvillei, from Argentina

Polizzi¹,

Romero²,

Boudet³

et al. 2014

Marine Pollution Bulletin

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a b s t r a c tMetallothioneins are signals of metal exposure and widely used in biomonitoring. Franciscana dolphin is an endemic cetacean from the Southwestern Atlantic Ocean, classified as Vulnerable A3d by the IUCN. Metallothionein, copper and zinc in Franciscana were assessed in two geographic groups; one inhabits La Plata River estuary, anthropogenically impacted, and the other inhabits marine coastal ecosystems, with negligible pollution. Despite the environment, hepatic and renal MT concentrations were similar, but there was a declining trend from early to later developmental stages. Metallothionein K/L, Cu and Zn levels corresponded to normal reported ranges. MT was not related with Cd. Fetal concentrations were higher than its mother. These results and the health status of dolphins are suggesting that MT correspond to physiological ranges for the species, and they are closely to homeostasis of Zn and Cu, according to its ontogenetic changes. The information constitutes the first MT information on Franciscana dolphin and can be considered as baseline for the species conservation.

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Section: Discussionsupporting

confidence: 77%

Metallothioneins pattern during ontogeny of coastal dolphin, Pontoporia blainvillei, from Argentina

Polizzi¹,

Romero²,

Boudet³

et al. 2014

Marine Pollution Bulletin

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“…It is known that external factors such as heavy metals and tobacco smoking can affect expression of SOD and MT. The deletion of genes encoding SOD or MT can result in disorders in human organisms physiology [13][14][15][16]. First, Ghoshal et al [17] have suggested that the decrease in Cu/ Zn SOD activity can cause the increase in MT concentration.…”

Section: Blood Collectionmentioning

confidence: 99%

Participation of metallothionein and superoxide dismutase in the blood of smoking smelters

Bizoń¹,

Milnerowicz²

2014

International Journal of Occupational Medicine and Environmental Health

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Objectives: Metallothionein (MT) and two forms of superoxide dismutase (SOD), which are dependent on zinc and copper ions, are involved in defense against the same superoxide anion radicals and are present in extra-and intracellular compartments. The aim of our study was to investigate MT concentration and Cu/Zn SOD activity in the plasma and erythrocyte lysate of the non-smoking and smoking smelters. Material and Methods: The investigations were performed in the blood of 300 male smelters and 100 non-exposed male subjects. We have measured zinc, copper, malondialdehyde (MDA) and MT concentrations as well as SOD activity. Results: We have observed an increase of Cu/Zn coefficient and decrease of Zn/Cu coefficient in the serum of smelters in comparison with the non-smoking control group. Concentration of MDA in the plasma of smelters was higher in comparison with its concentration in the non-smoking control group. The plasma and the erythrocyte lysate MT concentration increased significantly in the whole group of smelters as compared to the non-smoking control group. The mean value of MT concentration in plasma of the smoking smelters was above 2-fold higher than in the non-smoking control group. The activity of Cu/Zn SOD in plasma of the smoking and non-smoking smelters was decreased in comparison with the smoking and non-smoking control groups, respectively. The lowest activity of Cu/Zn SOD, about 2-3-fold decreased in comparison with the smoking and non-smoking control groups, was detected in plasma of the smelters. An inverse relationship was observed in the erythrocyte lysate. The highest activity of Cu/Zn SOD was reported in the erythrocyte lysate of the smoking smelters and it was about 2-fold higher than in the non-smoking control group. Conclusions: In extracellular environment MT plays a crucial role in comparison with the SOD, while in the intracellular compartment Cu/Zn SOD and MT cooperate with each other.

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“…Cadmium (Cd) has been ranked 7 th in the top 20 Hazardous Substances Priority List [1]. Acute Cd poisoning causes pulmonary edema, fulminate hepatitis, haemorrhage, testicular injury and lethality whereas prolonged exposure to Cd causes bio-accumulative damage to various organ systems [2,3]. Liver is the main target organ for short-term Cd toxicity.…”

Section: Introductionmentioning

confidence: 99%

Evaluating the Protective Efficacy of Combination and Withania Somnifera and Vitamin E Against Cadmium Induced Oxidative Stress Mediated Hepatic Histopathology and Genotoxicity in Murine Model

Rani

Sharma

Chopra

2017

Int J Pharm Pharm Sci

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Objective: Cadmium (Cd) exposure develops various serious pathological conditions because of its long-term retention in tissues. Withania somnifera (WS) is a known antioxidant due to its pharmacological properties, whereas vitamin E (VE) is a dietary antioxidant. The present study tries to study the combinational effect of WS and VE against Cd-induced toxicity.Methods: Amelioration of Cd-induced toxicity by WS and VE was evaluated in mice liver by studying biochemical, morphological and genotoxic parameters. For this study mice (n=6) were given short-term Cd exposure of 5 mg/kg b. wt. intraperitoneally (ip) for 5 d. WS leaf extract was given orally (500 mg/kg b. wt.) and in combination with VE (100 mg/kg b. wt.) to study its preventive effects against Cd-induced oxidative stressmediated histopathological and genotoxic alterations.Results: Cd significantly enhanced lipid peroxidation (LPO (p<0.0001) and declined the levels of antioxidant viz. reduced glutathione (GSH (p ≤ 0.0001), glutathione-S-Transferase (GST (p ≤ 0.0001 ), superoxide dismutase (SOD (p ≤ 0.0001 ) and catalase (CAT) (p ≤ 0.0001) activity. Histopathological examination of Cd-treated mice liver exhibited marked structural damage. Metal generated oxidative stress and imbalance of proand antioxidants forms the basis for marked structural changes and genotoxicity. Individual treatments of WS and VE reduced the Cd-induced toxicity but when WS was given in combination with VE for the same period, levels of antioxidants were brought to near normal levels.Conclusion: WS in combination with VE reduced Cd-induced oxidative burden and restored the levels of anti-oxidant enzymes resulting into improved histoarchitecture and reduced genotoxic insult.

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Blood Metallothionein Transcript as a Biomarker for Metal Sensitivity: Low Blood Metallothionein Transcripts in Arsenicosis Patients from Guizhou, China

Cited by 66 publications

References 38 publications

Metallothioneins pattern during ontogeny of coastal dolphin, Pontoporia blainvillei, from Argentina

Metallothioneins pattern during ontogeny of coastal dolphin, Pontoporia blainvillei, from Argentina

Participation of metallothionein and superoxide dismutase in the blood of smoking smelters

Evaluating the Protective Efficacy of Combination and Withania Somnifera and Vitamin E Against Cadmium Induced Oxidative Stress Mediated Hepatic Histopathology and Genotoxicity in Murine Model

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