Blood oxygenation using microbubble suspensions

Matsuki, Noriaki; Ichiba, Shingo; Ishikawa, Takuji; Nagano, Osamu; Takeda, Motohiro; Ujike, Yoshihito; Yamaguchi, Takami

doi:10.1007/s00249-012-0811-y

Cited by 45 publications

(67 citation statements)

References 25 publications

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“…NaCl and glucose inhibited increases in PO 2 values of oxygen microbubbles in accordance with concentration. 25 The increase in PO 2 value and the lifespan after OFMNB treatments in common infusion solutions were examined to explore the capability of applying OFMNBs. NSS is a basic crystalloid solution, dextran was used as a semisynthetic colloid solution, albumin for a blood-derived colloid solution, and intravenous soybean oil was used as a lipid solution.…”

Section: Discussionmentioning

confidence: 99%

“…25 However, there have been no reports comparing OFMNB fluids to other fluids commonly used in daily medical care. The present study had three goals: 1) to determine whether fine micro/ nanobubbles (FMNBs) could be used to efficiently increase the level of dissolved oxygen in liquids; 2) to ascertain which solutions are preferable for use as oxygen-rich infusion fluids; and 3) to investigate whether OFMNB-containing fluids can actually improve blood oxygenation.…”

Section: Introductionmentioning

confidence: 99%

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Oxygen supersaturated fluid using fine micro/nanobubbles

Matsuki¹,

Ishikawa²,

Ichiba³

et al. 2014

IJN

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Microbubbles show peculiar properties, such as shrinking collapse, long lifetime, high gas solubility, negative electric charge, and free radical production. Fluids supersaturated with various gases can be easily generated using microbubbles. Oxygen microbubble fluid can be very useful for oxygen delivery to hypoxic tissues. However, there have been no reports of comparative investigations into adding fluids containing oxygen fine micro/nanobubbles (OFM-NBs) to common infusion solutions in daily medical care. In this study, it was demonstrated that OFMNBs can generate oxygen-supersaturated fluids, and they may be sufficiently small to infuse safely into blood vessels. It was found that normal saline solution is preferable for generating an oxygen-rich infusion fluid, which is best administered as a 30-minute intravenous infusion. It was also concluded that dextran solution is suitable for drug delivery substances packing oxygen gas over a 1-hour intravenous infusion. In addition, normal saline solution containing OFMNBs was effective for improving blood oxygenation. Thus, the use of OFMNB-containing fluids is a potentially effective novel method for improving blood oxygenation in cases involving hypoxia, ischemic diseases, infection control, and anticancer chemoradiation therapies.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Oxygen supersaturated fluid using fine micro/nanobubbles

Matsuki¹,

Ishikawa²,

Ichiba³

et al. 2014

IJN

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“…255,256,257,258 Moreover, the opportunity exists currently to further test the effects of supplemental O 2 ; more modern standards of clinical trials such as establishing dose/response, effects of treatment duration, minimum dosing necessary etc. should surely be attempted as a simple yet potentially effective intervention.…”

Section: Potential Drug Targets Of Important Placental Pathways Imentioning

confidence: 99%

Placental origins of adverse pregnancy outcomes: potential molecular targets: an Executive Workshop Summary of the Eunice Kennedy Shriver National Institute of Child Health and Human Development

Ilekis

Tsilou

Fisher

et al. 2016

American Journal of Obstetrics and Gynecology

237

167

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Although much progress is being made in understanding the molecular pathways in the placenta involved in the pathophysiology of pregnancy related disorders, a significant gap exists in utilizing this information for developing new drug therapies to improve pregnancy outcome. On March 5–6, 2015, the Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health sponsored a two day workshop titled Placental Origins of Adverse Pregnancy Outcomes: Potential Molecular Targets to begin to address this gap. Particular emphasis was given in the identification of important molecular pathways that could serve as drug targets and the advantages and disadvantages of targeting these particular pathways. This article is a summary of the proceedings of this workshop. A broad number of topics were covered ranging from basic placental biology to clinical trials. This included research in the basic biology of placentation, such as trophoblast migration and spiral artery remodeling, and trophoblast sensing and response to infectious and non-infectious agents. Research findings in these areas will be critical for formulating developing future treatments and developing therapies for the prevention of a number of pregnancy disorders of placental origin including preeclampsia, fetal growth restriction, and uterine inflammation. Research was also presented summarizing ongoing clinical efforts in the U.S. and in Europe testing novel interventions for preeclampsia and fetal growth restriction, including agents such as oral arginine supplementation, sildenafil, pravastatin, gene therapy using virally-delivered vascular endothelial growth factor, and oxygen supplementation therapy. Strategies were also proposed to improve fetal growth by enhancing nutrient transport to the fetus by modulating their placental transporters, as well as targeting placental mitochondrial dysfunction and oxidative stress to improve placental health. The roles of microRNAs and placental-derived exosomes, as well as messenger RNAs, were also discussed in the context of their use for diagnostics and as drug targets. The workshop discussed the aspect of safety and pharmacokinetic profiles of potential existing and new therapeutics that will need to be determined especially in the context of the unique pharmacokinetic properties of pregnancy, as well as the hurdles and pitfalls of translating research findings into practice. The workshop also discussed novel methods of drug delivery and targeting during pregnancy using macromolecular carriers, such as nanoparticles and biopolymers, to minimize placental drug transfer and hence fetal drug exposure. In closing, a major theme that developed from the workshop was that the scientific community needs to change their thinking of the pregnant women and her fetus as a vulnerable patient population for which drug development should be avoided, but rather thought of as a deprived population in need of more effective therapeutic interventions.

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“…The unique ability of microbubbles to respond to ultrasound makes them useful agents for contrast ultrasound imaging [1][2][3][4] . The similar size of a microbubble as that of a red blood cell allows it to display similar rheology in the microvessels and capillaries throughout the body 5 , making them good mediators for targeted drug and gene delivery 2,6 and therapies 7,8 . In the environmental industry, the most common application of microbubbles is in the water and waste-water treatment [9][10][11][12][13] .…”

Section: Introductionmentioning

confidence: 99%

Spatial and temporal scaling of unequal microbubble coalescence

Chen

Zhu

et al. 2016

AIChE Journal

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We numerically study coalescence of air microbubbles in water, with density ratio 833 and viscosity ratio 50.5, using lattice Boltzmann method. The focus is on the effects of size inequality of parent bubbles on the interfacial dynamics and coalescence time. Twelve cases, varying the size ratio of large to small parent bubble from 5.33 to 1, are systematically investigated. The "coalescence preference", coalesced bubble closer to the larger parent bubble, is well observed and the captured power-law relation between the preferential relative distance χ and size inequality γ, χ ∼ γ −2.079 , is consistent to the recent experimental observations. Meanwhile, the coalescence time also exhibits power-law scaling as T ∼ γ −0.7 , indicating that unequal bubbles coalesce faster than equal bubbles.Such a temporal scaling of coalescence on size inequality is believed to be the first-time observation as the fast coalescence of microbubbles is generally hard to be recorded through laboratory experimentation.

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Blood oxygenation using microbubble suspensions

Cited by 45 publications

References 25 publications

Oxygen supersaturated fluid using fine micro/nanobubbles

Oxygen supersaturated fluid using fine micro/nanobubbles

Placental origins of adverse pregnancy outcomes: potential molecular targets: an Executive Workshop Summary of the Eunice Kennedy Shriver National Institute of Child Health and Human Development

Spatial and temporal scaling of unequal microbubble coalescence

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