Blood pressure and its reactivity in the offspring of first cousin hypertensive and first cousin normotensive parents: a preliminary report

Abstract

The aim of this preliminary study was to determine whether young offspring of first cousin hypertensive parent(s), have higher blood pressure (BP) reactivity in response to their first BP measurement, as compared to the offspring of first cousin normotensive parents. The BP of 135 boys aged 9-10 years was measured, for the first time ever, after a 10-min supine rest, and subsequently, twice at 10-min intervals. The offspring of first cousin hypertensive parent(s) reacted with signifi-

Prevalence of prehypertension and associated cardiovascular risk profiles among prediabetic Omani adults

“…In Oman, consanguinity is very common. Hassan et al [ 26 ] in their study, carried out in an urban sample of Omani population, found that 26% of the marriages were within their first cousin. At the national level this figure is very high.…”

“…At the national level this figure is very high. The first cousin marriage under the age of 50 years in 1995 was about 54% of total marriages [ 26 ]. This cultural practice may result into increase in both diabetes and hypertension.…”

Elevated blood pressure and obesity in young adults of hypertensive parent versus normotensive parent

“…3 Hassan et al has also reported the significant increase in diastolic pressure in offspring of hypertensive parents. 13 Even though p-value is not significant for heart rate between group-I and group-II, mean+SD is higher among individuals of group-I. Increased resting heart rate in offspring of single or both parent hypertensive has been associated with increase in cardiovascular morbidities.…”

Heritability of Hemodynamic Reactivity to Laboratory Stressors in a Homogenous Arab Population: ‘Oman Family Study’

“…Twin studies using mental stress tests reported significant h 2 for ΔSBP but not for Δ DBP (Busjahn et al, 1996;de Geus et al, 2007). Studies using stress to expose genetic variance focused mainly on the reactivity of BP in normal and /or probands of hypertensive subjects (Gottesman & Gould, 2003;Hassan et al, 2001;Rice et al, 1999). As BP itself is a complex phenotype controlled by several regulatory mechanisms, it was proposed that the study of intermediate traits, as compared to the final disease state, may have several advantages for the genetic dissection of complex diseases such as hypertension (Sing et al, …”