Blood pressure control in type 2 diabetic patients

Grossman, Alon; Grossman, Ehud

doi:10.1186/s12933-016-0485-3

Cited by 107 publications

(95 citation statements)

References 119 publications

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“…Essential hypertension (EH) is recognized as the leading cause in global death of vascular disease [ 23 ]. Although the BP targets in diabetic hypertensive individuals are controversial, it was common practice to aim for BP targets lower than 130/80 mmHg in most diabetic patients [ 24 ], which will help reduce cardiovascular events (e.g., at least stroke) [ 39 ]. In this study we found that 7 diabetic risk related ACE2 SNPs were associated with increased SBP or DBP with exception of rs1978124.…”

Section: Discussionmentioning

confidence: 99%

ACE2 polymorphisms associated with cardiovascular risk in Uygurs with type 2 diabetes mellitus

Cheng

Guan

et al. 2018

Cardiovasc Diabetol

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BackgroundType 2 diabetes mellitus (T2D), rapidly increasing to epidemic proportions, globally escalates cardiovascular disease risk. Although intensive interventions and comprehensive management of environmental risks factors for T2D are associated with reduced cardiovascular disease, such approaches are limited for individuals with high genetic T2D risk. In this study we investigated possible associations of ACE2 polymorphisms and cardiovascular risks in Uygur patients with T2D.Methods275 Uygur T2D patients and 272 non-diabetic Uygur individuals were enrolled as study participants. 14 ACE2 polymorphisms were genotyped by Matrix-assisted laser desorption ionization time-of-flight mass spectrometry.ResultsACE2 SNP rs1978124, rs2048683, rs2074192, rs233575, rs4240157, rs4646156, rs4646188 and rs879922 were associated with T2D (all P < 0.05). The 8 diabetic risk related ACE2 SNPs were further associated with diabetic related cardiovascular complications or events but exhibited heterogeneity as fellows: firstly, almost all diabetic risk related ACE2 SNPs (all P < 0.05) were associated with increased SBP except rs1978124 and rs2074192, while rs2074192, rs4646188 and rs879922 were associated elevated DBP (all P < 0.05). Secondly, SNP rs4646188 was not correlated with any type of dyslipidemia (TRIG, HDL-C, LDL-C or CHOL), and the other 7 diabetic risk related loci were at least correlated with one type of dyslipidemia (all P < 0.05). In particular, rs879922 were simultaneously correlated with four type of dyslipidemia (all P < 0.05). Thirdly, ACE2 SNP rs2074192 and rs879922 were associated with carotid arteriosclerosis stenosis (CAS) ≥ 50% (both P < 0.05). Fourthly, ACE2 SNP rs2074192, rs4240157, rs4646188 and 879922 were associated with increased MAU (all P < 0.05). In addition, ACE2 SNP rs2048683, rs4240157, rs4646156, rs4646188 and rs879922 were linked to heavier LVMI (all P < 0.05), but only rs4240157, rs4646156 and rs4646188 were associated with lower LVEF (all P < 0.05).ConclusionACE2 SNP rs879922 may be a common genetic loci and optimal genetic susceptibility marker for T2D and T2D related cardiovascular risks in Uygurs.Electronic supplementary materialThe online version of this article (10.1186/s12933-018-0771-3) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

ACE2 polymorphisms associated with cardiovascular risk in Uygurs with type 2 diabetes mellitus

Cheng

Guan

et al. 2018

Cardiovasc Diabetol

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“…Moreover, about 75% of adults with diabetes presented blood pressure of greater or equal to 140/90 mm Hg (Shah & Afzal, ). The occurrence of hypertension in diabetic patients or vice‐versa substantially increases the risks of coronary heart disease, stroke, nephropathy and retinopathy (Schutta, ; Grossman & Grossman, ). Treatment of both conditions is essential and can lead to prescription of synthetic ACE‐inhibitors to diabetic patients.…”

Section: Introductionmentioning

confidence: 99%

Selective separation and characterisation of dual ACE and DPP‐IV inhibitory peptides from rainbow trout (Oncorhynchus mykiss) protein hydrolysates

Ketnawa

Suwal

Huang

et al. 2018

Int J of Food Sci Tech

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Microwave pretreatment and hydrolysis were applied to rainbow trout (Oncorhynchus mykiss) by-products to produce bioactive peptides with dual in vitro angiotensin-I converting enzyme (ACE) and dipeptidylpeptidase IV (DPP-IV) inhibitory activities. Peptides were fractionated using the single step electrodialysis with ultrafiltration membrane (EDUF). Concentration of cationic peptides (CP) increased in the recovery solution, reaching 125 lg mL À1 after a 4-h treatment with migration rate of 15.68 AE 2.98 g m À2 h. CP fractions displayed ACE and DPP-IV I inhibitory properties, with IC 50 values of 0.0036 mg mL À1 and 1.23 mg mL À1 respectively. The bioactivity was attributed to the low molecular weight peptides (300-500 Da) recovered. CP exhibited non-competitive inhibition patterns for ACE and DPP-IV, which were dose dependent. These results showed that bioactive peptides can successfully be separated from complex hydrolysate mixtures by EDUF. The fractionated peptides can serve as potential functional food ingredients or nutraceuticals for the management of hypertension and diabetes. Fractionation of active peptides by electrodialysis with ultrafiltration membraneA detailed description of the EDUF cell and operating conditions used for fractionation in this study is given in Suwal et al. (2018). Briefly, the cell configuration

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“…Different goals in defining blood pressure control and various guidelines in diabetic patients have made blood pressure control more difficult in this group. [32] Strengths And Limitations…”

Section: Discussionmentioning

confidence: 99%

Awareness, treatment, and control of hypertension and related factors in adult Iranian Population

Mehrara

Mirzaei

Bagheri-Fahraji

et al. 2020

Preprint

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BackgroundHypertension, known as the silent killer, is a major risk factor for cardiovascular disease. This study aims to estimate awared, treated, and controlled hypertensive and relevant predictors in an adult Iranian population. MethodsThis cross-sectional study was conducted on 10000 adults aged 20-69 years in Yazd, Iran. They were selected through multi-stage random cluster sampling in 2015-2016.Blood pressure was measured three-time with standard protocol by trained health workers. Those with a positive history of hypertension and using anti-hypertensive drugs, prescribed by a physician, were considered hypertensive. Hypertension was defined as systolic blood pressure ≥140 mmHg and/or diastolic BP of ≥90 mmHg. Uncontrolled hypertension was defined in accordance with recommended treatment targets by the Joint National Committee (JNC7). Logistic regression was used to assess the predictors of hypertension awareness, treatment and control. ResultsThe prevalence of hypertension was 37.3%, and the prevalence of pre-hypertension was 46.4%. 49.7% of People with hypertension were aware of their disease, and 71.5% of them were using antihypertensive drugs prescribed by physicians. Blood pressure was controlled in 38.9% of the treated patients. In the adjusted model, older age, female sex, and history of diabetes mellitus were positively associated with higher awareness. High physical activity, tobacco smoking, and diabetes are the only predictors of treated high blood pressure. Younger age, female sex, and higher education were determinants of controlled hypertension. Having health insurance was significantly correlated with awareness and control of hypertension. ConclusionHypertension is a public health problem in this population, which is not well controlled. Half of the patients were unaware. Intervention for increased screening coverage is needed. It should plan to raise public awareness about hypertension and improve hypertension control under supervision of 3 physicians. Implement a family physician program is recommended in the health system.

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Blood pressure control in type 2 diabetic patients

Cited by 107 publications

References 119 publications

ACE2 polymorphisms associated with cardiovascular risk in Uygurs with type 2 diabetes mellitus

ACE2 polymorphisms associated with cardiovascular risk in Uygurs with type 2 diabetes mellitus

Selective separation and characterisation of dual ACE and DPP‐IV inhibitory peptides from rainbow trout (Oncorhynchus mykiss) protein hydrolysates

Awareness, treatment, and control of hypertension and related factors in adult Iranian Population

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