Blood Pressure Variability: A New Predicting Factor for Clinical Outcomes of Intracerebral Hemorrhage

Andalib, Sasan; Lattanzi, Simona; Napoli, Mario Di; Petersen, Alexander; Biller, José; Kulik, Tobias; Macri, Elizabeth; Girotra, Taurn; Torbey, Michel T.; Divani, Afshin A.

doi:10.1016/j.jstrokecerebrovasdis.2020.105340

Cited by 30 publications

(31 citation statements)

References 43 publications

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“… 15 BPV can be measured using various parameters such SD, CV, residual SD, successive variation (SV), mean absolute change (MAC), and average real variability (ARV). 16 , 32 …”

Section: Discussionmentioning

confidence: 99%

“…Systematic chart reviews were performed to extract demographics including age, sex and race/ethnicity, clinical information such as symptoms, diagnosis, NIH Stroke Scale (NIHSS), laboratory data such as coagulation and inflammatory markers, neuroimaging findings, and outcomes. Amongst the various parameters, blood pressure variability (BPV) 15 , 16 and neutrophil to lymphocyte ratio (NLR) 17 were analyzed separately to determine if there was a correlation between them and ICH severity and outcome.…”

Section: Methodsmentioning

confidence: 99%

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Intracranial Hemorrhage in COVID-19 Patients

Mishra

Choueka

Wang

et al. 2021

Journal of Stroke and Cerebrovascular Diseases

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“… 15 BPV can be measured using various parameters such SD, CV, residual SD, successive variation (SV), mean absolute change (MAC), and average real variability (ARV). 16 , 32 …”

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Intracranial Hemorrhage in COVID-19 Patients

Mishra

Choueka

Wang

et al. 2021

Journal of Stroke and Cerebrovascular Diseases

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“…Recent evidence suggests that high blood pressure and blood pressure variability are important factors in predicting the prognosis of acute stroke. In particular, it is known that systolic blood pressure at admission and systolic blood pressure variability increase the risk of cerebral hemorrhage or symptomatic hemorrhagic transformation, and adversely affect mortality and functional outcome [ 30 , 31 , 32 ]. As a result of our study, in the comparison between the expired group and the surviving group, there was no difference in SBP at admission, but in the case of SBPV, there was a significant difference between the two groups.…”

Section: Discussionmentioning

confidence: 99%

Significantly Reduced Alanine Aminotransferase Level Increases All-Cause Mortality Rate in the Elderly after Ischemic Stroke

Yang

Jeon

et al. 2021

IJERPH

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(1) Background: A significantly reduced alanine aminotransferase (ALT) level is being recognized as a risk factor of increasing mortality in the elderly in relation to frailty. In the elderly, both frailty and ischemic stroke are not only common, but are also associated with mortality. The aim of this research was to investigate whether a significantly reduced ALT level increases the all-cause mortality rate in the elderly with ischemic stroke. (2) Methods: Between February 2014 and April 2019, a retrospective study of 901 patients with ischemic stroke admitted to a university-affiliated hospital was conducted. Cox proportional hazard regression was used to determine whether a significantly reduced ALT level is an independent risk factor for mortality in elderly patients after an ischemic stroke. (3) Results: This study enrolled 323 older adults (age ≥ 65 years) who were first diagnosed with ischemic stroke. The mean age of the participants was 76.5 ± 6.6 years, the mean survival time was 37.1 ± 20.4 months, and the number of deaths was 96 (29.7%). Our results showed that reduced ALT level (less than 10 U/L) increased the risk of all-cause mortality in the elderly after ischemic stroke (adjusted HR: 3.24, 95% CI: 1.95–5.41; p < 0.001). (4) Conclusions: A significantly reduced ALT level at the time of diagnosis (less than 10 U/L) is an independent risk factor that increases the mortality rate in the elderly after ischemic stroke.

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“…Thirdly, recent emerging lines of evidence suggest that high blood pressure variations are important predictors of the prognosis of ICH. 28 , 29 However, our study did not take this factor into account. Finally, we had little background information, such as purine consumption, history of gout and exercise habit that would affect admission serum UA concentration.…”

Section: Discussionmentioning

confidence: 98%

High Uric Acid Level Predicts Early Neurological Deterioration in Intracerebral Hemorrhage

Xiao¹,

Lu²,

Feng³

et al. 2021

NDT

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Objective Increased level of serum uric acid (UA) is often considered a risk factor for ischemic stroke. However, there are limited data on the association between UA and intracerebral hemorrhage (ICH). This study aimed to examine the connection between UA and early neurological deterioration (END) in patients with ICH. Methods This is a prospective observational study. Patients with ICH were enrolled from January 2017 to December 2020. END was diagnosed as the Canadian Stroke Scale (CSS) score decreased ≥1 points between admission and 48 hours. UA was measured at admission. Multivariable logistic regression analysis was performed to explore the relationship between serum UA and END. Results Of the 498 enrolled patients, 132 (26.5%) were developed with END. Patients with END had a significantly higher level of serum UA (332 vs 270 µmol/L, P < 0.001). Univariate logistic regression analysis indicated that patients with the highest quartile of UA level had an OR of 3.256 (95% CI: 1.849–5.734, P < 0.001) for END compared with those with the lowest quartile of UA level. After adjusting for major confounders, the highest UA quartile remained as an independent predictor for END (OR = 2.282, 95% CI: 1.112–4.685, P = 0.013). Conclusion Higher serum UA level was independently associated with END in patients with ICH; therefore, intervention to lower UA level may be worth considering.

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Blood Pressure Variability: A New Predicting Factor for Clinical Outcomes of Intracerebral Hemorrhage

Cited by 30 publications

References 43 publications

Intracranial Hemorrhage in COVID-19 Patients

Intracranial Hemorrhage in COVID-19 Patients

Significantly Reduced Alanine Aminotransferase Level Increases All-Cause Mortality Rate in the Elderly after Ischemic Stroke

High Uric Acid Level Predicts Early Neurological Deterioration in Intracerebral Hemorrhage

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