Blood pressure variability as an adverse prognostic risk factor in end-stage renal disease

Tozawa, Masahiko; Iseki, Kunitoshi; Yoshi, Shinichiro; Fukiyama, Koshiro

doi:10.1093/ndt/14.8.1976

Cited by 80 publications

(79 citation statements)

References 26 publications

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“…Larger variability of office BP was associated with a higher risk of stroke in elderly hypertensive patients 7 and with higher mortality from all causes in end-stage renal disease patients undergoing haemodialysis. 8 These and the present findings suggest that long-term variability of BP predicts the risk of cardiovascular complications including stroke, MI, and mortality from all causes.…”

Section: Blood Pressure Variability and Subsequent Morbidity And Mortsupporting

confidence: 74%

“…7 Larger long-term variability of systolic BP was associated with higher mortality from all causes in endstage renal disease patients undergoing haemodialysis. 8 In the present case-control study, we focused on the relationship between office BP variability and the occurrence of acute MI. We explored the effects on the risk of acute MI of long-term office BP variability in elderly patients receiving antihypertensive therapy.…”

Section: Introductionmentioning

confidence: 99%

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Office blood pressure variability as a predictor of acute myocardial infarction in elderly patients receiving antihypertensive therapy

et al. 2002

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Larger variability of office blood pressure (BP) was reportedly associated with a higher risk of stroke or mortality from all causes. In the present study, we focused on the relationship of variability of office BP and occurrence of acute myocardial infarction (MI). We registered 139 patients receiving antihypertensive therapy for more than 1 year who experienced first-ever episode of MI at the age of 60 years or over. At least two sex-and age-matched (؎5 years) control patients were registered for every MI patient. Average systolic and diastolic BP during the 12-month period prior to the occurrence of MI, or the time of registration in the case of control patients, was similar in both patient groups. The office BP variability was evaluated by calculating

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Section: Blood Pressure Variability and Subsequent Morbidity And Mortsupporting

confidence: 74%

Section: Introductionmentioning

confidence: 99%

Office blood pressure variability as a predictor of acute myocardial infarction in elderly patients receiving antihypertensive therapy

et al. 2002

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“…[15][16][17][18] Nevertheless, it ought be mentioned that the majority of data cited below refer to the hypertensive adults and healthy children. There is a relative paucity of data concerning the problem in children and young adults with essential hypertension.…”

Section: Discussionmentioning

confidence: 99%

“…22,23 Moreover, the positive relationship between BPV and BP values in normotensive and hypertensive subjects was also approved. 15,24,25 The results of simple analysis documented that SBP determined both systolic and diastolic BPV more than DBP. In addition, in multivariate analysis, negative relationship between night time BPV and daytime DBP was observed.…”

Section: Blood Pressure Variability In Children L J Krzychmentioning

confidence: 97%

“…The results were accepted for analysis when at least 90% of valid readings were obtained during day and night. The minimal number of readings required for analysis was 58 for a daytime period (range 58-64) and 14 readings for a night time period (range [14][15][16]. The criteria used to classify BP measurements as non-valid were applied in accordance with the recommendations of the producer of the device (e.g.…”

Section: Blood Pressurementioning

confidence: 99%

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Blood pressure variability in children with essential hypertension

Krzych

2007

J Hum Hypertens

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The aim of this study was to assess blood pressure variability (BPV) and its determinants in untreated hypertensive children. The study group consisted of 124 children, 91 boys and 33 girls, aged 14.972.5 with essential hypertension and no use of antihypertensive drugs. The subjects underwent routine examination, blood tests and ambulatory blood pressure (BP) monitoring. BPV was defined as the value of the standard deviation of BP for day-and night time periods. Daytime BPV was higher than night time BPV, and systolic BPV was higher than diastolic BPV. Significant positive correlations between 24-h, day-and night time systolic blood pressure (SBP), but not for diastolic blood pressure (DBP), and BPV were observed. In univariate analysis, day-and night time systolic BPVs were correlated with fasting glucose (r ¼ 0.609, P ¼ 0.02 and r ¼ 0.439, P ¼ 0.04); daytime systolic BPV, daytime diastolic BPV and night time systolic BPV were correlated with birth length (r ¼ 0.428, P ¼ 0.04; r ¼ 0.426, P ¼ 0.04 and r ¼ 0.439, P ¼ 0.04, respectively), and night time systolic BPV and night time diastolic BPV were correlated with age (r ¼ 0.604, P ¼ 0.02 and r ¼ 0.833, P ¼ 0.0001). However, in multiple linear regression analysis, daytime diastolic BPV was determined only by gender and systolic 24-h BP; night time systolic BPV depended on age, daytime SBP and DBP values, and daytime SBP and DBPs were determinants of night time diastolic BPV. The results highlighted the complex nature of BPV, with favourable role of host factors in its aetiology. The determinants of BPV in children are consistent with those in adults. Relationships between BPV and its determinants in untreated hypertensive subjects ought to be investigated in further researches.

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Linear and nonlinear measures of blood pressure variability: Increased chaos of blood pressure time series in patients with panic disorder

et al. 2004

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Arterial blood pressure (BP) variability increases progressively with the development of hypertension and an increase in BP variability is associated with end organ damage and cardiovascular morbidity. On the other hand, a decrease in heart rate (HR) variability is associated with significant cardiovascular mortality. There is a strong association between cardiovascular mortality and anxiety. Several previous studies have shown decreased HR variability in patients with anxiety. In this study, we investigated beat-to-beat variability of systolic and diastolic BP (SBP and DBP) in normal controls and patients with panic disorder during normal breathing and controlled breathing at 12, and 20 breaths per minute using linear as well as nonlinear techniques. Finger BP signal was obtained noninvasively using Finapres. Standing SBPvi and DBP BPvi (log value of BP variance corrected for mean BP divided by HR variance corrected for mean HR) were significantly higher in patients compared to controls. Largest Lyapunov exponent (LLE) of SBP and DBP, a measure of chaos, was significantly higher in patients in supine as well as standing postures. The ratios of LLE (SBP/HR) and LLE (DBP/HR) were also significantly higher (P<.001) in patients compared to controls. These findings further suggest dissociation between HR and BP variability and a possible relative increase in sympathetic function in anxiety. This increase in BP variability may partly explain the increase in cardiovascular mortality in this group of patients.

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Blood pressure variability as an adverse prognostic risk factor in end-stage renal disease

Abstract: These results suggest that systolic blood pressure variability may be a significant prognostic factor in end-stage renal disease.

Cited by 80 publications

References 26 publications

Office blood pressure variability as a predictor of acute myocardial infarction in elderly patients receiving antihypertensive therapy

Office blood pressure variability as a predictor of acute myocardial infarction in elderly patients receiving antihypertensive therapy

Blood pressure variability in children with essential hypertension

Linear and nonlinear measures of blood pressure variability: Increased chaos of blood pressure time series in patients with panic disorder

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