Blood Trace Element Status in Multiple Sclerosis: a Systematic Review and Meta-analysis

Nirooei, Elahe; Kashani, Seyyed Mohammad Amin; Owrangi, Soroor; Malekpour, Fatemeh; Niknam, Maryam; Moazzen, Fatemeh; Nowrouzi-Sohrabi, Peyman; Farzinmehr, Somaye; Akbari, Hamed

doi:10.1007/s12011-021-02621-5

Cited by 26 publications

(17 citation statements)

References 59 publications

(48 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Characterized by an immune-mediated disease caused by an autoimmune attack on the central nervous system (CNS) and the progressive demyelination through chronic inflammation, multiple sclerosis (MS) is one of the most common neurological diseases (Dehghanifiroozabadi et al, 2019[ 12 ]; Nirooei et al, 2021[ 36 ]). The onset and progression of MS have been attributed to irreversible degeneration of myelinated axon accompanied by the lower capability for remyelination in the early stages and plaques formation as a result of the chronicity in later stages (Cariccio et al, 2019[ 8 ]).…”

Section: Introductionmentioning

confidence: 99%

Toxic heavy metal concentrations in multiple sclerosis patients: a systematic review and meta-analysis

Sarihi

Niknam

Mahjour

et al. 2021

EXCLI Journal; 20:Doc1571; ISSN 1611-2156

Self Cite

View full text Add to dashboard Cite

The present meta-analysis was performed to assess the association between MS patients and control subjects in terms of their circulating levels of arsenic (As), lead (Pb), mercury (Hg), and cadmium (Cd). We searched Medline/PubMed, Scopus, Web of Science, and Embase up until June 2020 to identify all studies that examined the concentrations of heavy metals in MS patients. Statistical tests used to assess inter-study heterogeneity were Cochrane's Q test and the I 2 statistic. Given the observed significant heterogeneity, the random-effects model was employed to pool the weighted mean differences (WMDs) and the corresponding 95 % confidence intervals (CIs). Out of a total of 1181 articles, 16 studies with 1650 participants (772 patients with MS and 878 controls) were included in this review meta-analysis. Pooled results using random-effects model showed that the levels of Pb (WMD= 0.73 µg/L, 95 % CI= 0.33 to 1.12, P< 0.001), As (WMD= 2.48 μg/L, 95 % CI= 1.44 to 3.53, P <0.001; I 2 = 98.9 %, P <0.001), and Cd (WMD= 0.17 μg/L, 95 % CI= 0.09 to 0.26, P <0.001) were significantly higher in MS patients than those of the controls. However, there were no significant differences in the levels of Hg (WMD= -0.14 µg/L, 95 % CI= -0.77 to 0.49, P= 0.658) among both groups. Sensitivity analysis indicated that after excluding one-by-one study, the overall pooled WMD of Pb was changed. This meta-analysis showed that patients with MS had significantly higher levels of circulatory As and Cd compared to the controls. Yet, there was no statistically significant difference between circulating levels of Hg and Pb among MS patients and controls. See also Figure 1 (Fig. 1) .

show abstract

Section: Introductionmentioning

confidence: 99%

Toxic heavy metal concentrations in multiple sclerosis patients: a systematic review and meta-analysis

Sarihi

Niknam

Mahjour

et al. 2021

EXCLI Journal; 20:Doc1571; ISSN 1611-2156

Self Cite

View full text Add to dashboard Cite

show abstract

“…5,38 İmmün hücre sağlığını, normal fizyolojik işleyişin devamlılığı ve MS hastalığına bağlı artan inflamatuar belirteçlerin normalizasyonu için vitamin-mineral yetersizliğinin tespit ve müdahale edilmesi gerekmektedir. 9,45 Çünkü yetersizliğin kronikleşmesine bağlı olarak MS hastalık yükü, nöral hücre defekti, miyelin ve aksonal hasarı ve klinik bulgular artabilir, fakat bu konuda yeterli kanıt düzeyi bulunmamaktadır. 10,17 Probiyotik ve koenzim Q10 gibi biyoaktif bileşenler inflamatuar süreci regüle etmeye yardımcı olabilir.…”

Section: Diğer Mikro Besin öGeleriunclassified

“…8 Yapılan çalışmalar sonucunda, hastalarda malnütrisyon, obezite, kaşeksi, vitamin-mineral eksikliği gibi çeşitli kötü beslenme durumu olduğu saptanmıştır. 9,28,45 MS hastalarının besin alımını ve beslenme durumu; fiziksel aktivite, yorgunluk, bilişsel zorluk, görme sorunları, kas spazmları, mide bulantısı, diyare, bası yaraları, disfaji, ilaç tedavisi ve ilaç-besin etkileşimini olumsuz yönde etkilemektedir. 9,15,16 MS'de kaşeksi sık görüldüğü için hastalarda nütrisyonel durum dikkatli incelenmelidir.…”

Section: Ms Hastaliği Ve Beslenme Sorunlariunclassified

“…49 MS hastalarında kas spazmları ve yorgunluğa bağlı hareketsizlik, steroid, antidepresan kullanımı ve inaktif yaşam obeziteye de neden olabilmektedir. 45,49 Hastanın tıbbi öyküsü (ilaç, diyet, tanı), laboratuvar bulguları, fiziksel muayene, vücut kompozisyonu, potansiyel disfajinin tespiti değerlendirilip, bireysel enerji-besin ögesi gereksinimine yönelik beslenme programı diyetisyen tarafından planlanmalıdır. 21 Tablo 3'te MS hastalığında görülen beslenme sorunları incelenmiştir.…”

Section: Ms Hastaliği Ve Beslenme Sorunlariunclassified

See 1 more Smart Citation

Nutrition and Nutritional Problems in Multiple Sclerosis Disease: Traditional Review

ÖZMUTAF¹

2022

Turkiye Klinikleri J Health Sci

View full text Add to dashboard Cite

Multipl skleroz (MS), santral sinir sistemini etkileyen kronik otoimmün bir hastalıktır. 1 MS ilk olarak 1868 yılında Jean-Martin Charcot tarafından tanımlanmıştır. 2 MS hastalığı genellikle ataklarla seyretmektedir ve atak sonrasında sekeller birikmekte-dir. Bu sebeple progresif dejeneratif bir süreç gelişerek hastaların yaşam kalitesi ciddi oranda azalmakta ve progresif engelliliğe neden olmaktadır. 2 Dünya çapında prevalansı yaklaşık 2,3 milyon iken, Türkiye İstatistik Kurumu 2017 verilerine göre sinir hastalık-

show abstract

“…U nizu epidemioloških studija ukazano je i da se kod obolelih od ulceroznog kolitisa i Kronove bolesti redovno nalaze niže koncentracije selena u serumu u odnosu na zdrave osobe 33 . Što se tiče multiple skleroze, nisu uočene značajne razlike u koncentraciji selena u organizmu obolelih i zdravih osoba 34 .…”

Section: Selen I Autoimune Bolestiunclassified

Selenium: Role in preserving and improving health and preventing disease

Belojević¹

2022

Galenika Med J

View full text Add to dashboard Cite

Introduction: Selenium is a trace element whose importance for the functioning of the organism in health and disease is very intensively studied in modern research. This scientific evidence is constantly being supplemented, which requires monitoring and evaluation. Aim: The aim of this review paper is to systematize the results of relevant scientific research on the role of selenium in health preservation and promotion and the prevention of disease. Method: Available literature in English from the PubMed database was searched using the keywords "selenium"; "health"; "disease"; "toxicity"; "food"; "deficiency"; "cancer" and "diabetes mellitus". Results: Selenium is a microelement that manifests a powerful antioxidant effect within the enzyme phospholipid hydroperoxide glutathione peroxidase, while as a part of the enzyme deiodinase plays a role in the transformation of thyroxine into triiodothyronine. Brazilian nut is a food with an extremely high concentration of selenium, followed by tuna and oysters. Selenium deficiency in the body manifests as cardiomyopathy (Keshan disease) or osteoarthritis (Kashin-Beck's disease). Selenium poisoning is characterized by gastrointestinal and neurological symptoms, changes in the skin, on nails and garlic breath. Although a negative correlation has been observed between selenium concentration and the risk of carcinoma (breast, prostate, cervical, liver, gastric, thyroid, colorectal and bladder), studies have not shown so far a significant effect of selenium nutritional intake or supplementation in the prevention of cancer. Selenium concentrations are significantly lower in hepatitis, cirrhosis of the liver, obesity, autoimmune diseases (Hashimoto's disease, psoriasis, rheumatoid arthritis, ulcerous colitis, Crohn's disease), AIDS, and COVID-19, compared to healthy people. On the other hand, excessive selenium intake can increase the risk of diabetes mellitus type 2. Conclusion: Selenium has a significant physiological role in preserving health, primarily as an antioxidant and in the functioning of the thyroid gland, while selenium deficiency can be manifested by cardiomyopathy and osteoarthritis. Low concentrations of selenium in the body may increase the risk of several diseases: cancer, autoimmune diseases, AIDS and COVID-19. On the other hand, excessively high doses of selenium may increase the risk of diabetes mellitus or even poisoning - selenosis.

show abstract

Blood Trace Element Status in Multiple Sclerosis: a Systematic Review and Meta-analysis

Cited by 26 publications

References 59 publications

Toxic heavy metal concentrations in multiple sclerosis patients: a systematic review and meta-analysis

Toxic heavy metal concentrations in multiple sclerosis patients: a systematic review and meta-analysis

Nutrition and Nutritional Problems in Multiple Sclerosis Disease: Traditional Review

Selenium: Role in preserving and improving health and preventing disease

Contact Info

Product

Resources

About