Blood transfusion for preventing primary and secondary stroke in people with sickle cell disease

Estcourt, Lise J; Fortin, P; Hopewell, Sally; Trivella, Marialena; Wang, Winfred C.

doi:10.1002/14651858.cd003146.pub3

Cited by 26 publications

(27 citation statements)

References 92 publications

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“…In addition, the carcinogenic and teratogenic potential of the drug should be considered [21] [23] [27] [34] [45] [46].…”

Section: Discussionmentioning

confidence: 99%

“…In sickle cell anemia, there is an increase of cerebral blood flow speed due to severe anemia. The high blood flow velocity when measured by TCD is a powerful predictor of stroke, which the risk increases in the direct proportion with the increase of the time-averaged of the maximum velocity-TAMMX (21). TAMMX was used in the development of the STOP TCD velocity criteria [7] [31].…”

Section: Diagnostic Imaging Methods Tcdmentioning

confidence: 99%

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Transcranial Doppler Ultrasonography to Prevent Cerebrovascular Accident in Children with Sickle-Cell Disease

Carpentieri-Pipolo¹,

Oliveira²,

Paschoal³

et al. 2019

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Sickle-cell disease (SCD) is the most common cause of ischemic stroke in children and it happens in about 11% of patients between the age of 2 and 20 years old. About 7% of the world population is affected by hemoglobin disorders, mostly sickle cell anemia. SCD has a high prevalence in the population of African offspring and it is a public health problem in Brazil that affects more than 30,000 million people. Prevention of primary stroke might be feasible with a way to identify children at greatest risk. Transcranial Doppler Ultrasonography (TCD) to SCD patients can be a valuable service that results in a significant decrease of first stroke rates. In this work, we present a review about TCD as an effective strategy to detect children with SCD who are at risk for stroke.

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“…In addition, the carcinogenic and teratogenic potential of the drug should be considered [21] [23] [27] [34] [45] [46].…”

Section: Discussionmentioning

confidence: 99%

Section: Diagnostic Imaging Methods Tcdmentioning

confidence: 99%

Transcranial Doppler Ultrasonography to Prevent Cerebrovascular Accident in Children with Sickle-Cell Disease

Carpentieri-Pipolo¹,

Oliveira²,

Paschoal³

et al. 2019

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“…in the treatment of acute SCD-related vaso-occlusive complications. 2,3 While the overall prevalence of vasoocclusive crisis and CVA in SCD are high, the development of MSOF is considered rare.…”

Section: Discussionmentioning

confidence: 99%

“…Specific risk factors for CVA include a history of transient ischemic attack, recent episode of acute chest syndrome, and SCD genotype, with HbSS and HbSβ° carrying the greatest risk . Red blood cell (RBC) transfusion is used in the chronic setting as primary and secondary stroke prophylaxis for patients with SCD, as well as episodically in the treatment of acute SCD‐related vaso‐occlusive complications . While the overall prevalence of vaso‐occlusive crisis and CVA in SCD are high, the development of MSOF is considered rare.…”

mentioning

confidence: 99%

Transfusion‐transmitted malaria masquerading as sickle cell crisis with multisystem organ failure

et al. 2018

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Clinical suspicion for transfusion-related adverse events, including hemolytic transfusion reactions and transfusion-transmitted infections, should be high in typically and atypically immunocompromised patient populations (like SCD), especially those on chronic transfusion protocols. Manual blood smear review aids in the evaluation of patients with SCD presenting with severe vaso-occlusive crisis and MSOF and can alert clinicians to the need for initiating aggressive therapy like RBC exchange and artesunate therapy.

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“…Although the incidence of stroke in SCD has decreased since the implementation of transcranial Doppler screening, some children still have stroke and sequelae of hemiparesis and/or cognitive deficits that require special disability accommodations. 18 The medical team for summer campers with SCD should be prepared to manage unpredictable acute sickle vasoocclusive pain, acute infection, and acute chest syndrome. The medical team must also be ready for emergency trans-port of a camper to a facility familiar with the care of SCD.…”

Section: Manage Bedwettingmentioning

confidence: 99%

Summer Camps for Children with Sickle Cell Disease

Narcisse

Walton²,

Hsu

2018

TOJ

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Background: Children with sickle cell disease (SCD) face unique problems that attendance at a camp with their peers is well suited to address. However, because the staff members at ordinary summer camps are not accustomed to accommodating children with chronic diseases, the potential for significant health consequences exists. Methods: We searched the literature in PubMed and CINAHL using the keywords summer camp, camp, sickle, and anemia to identify the unique characteristics of camps for children with SCD and the recommendations for care and/or lessons learned. Results: Published data are limited. Accommodations to avoid triggering sickle vaso-occlusive pain have been developed empirically and extrapolated from other settings. Camp experiences provide peer learning opportunities, positive role models, and a safe area to explore personal growth. The supportive atmosphere of the camp and escape from social stigma are welcome changes from the daily routine. Camp experiences can help with education on self-care and the transition from adolescent to adult healthcare. Conclusion: Camp offers unique opportunities for care coordination. Camps for children with SCD provide a setting for dissemination of best practices for the disease. Community-based organizations should partner in recruiting young adults with SCD as counselors. Educational material now available could be modified for use in the camp setting. All stakeholders in the care of children with SCD should work in unison to ensure these children enjoy the benefits of summer camp.

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Blood transfusion for preventing primary and secondary stroke in people with sickle cell disease

Abstract: Blood transfusion for preventing primary and secondary stroke in people with sickle cell disease.

Cited by 26 publications

References 92 publications

Transcranial Doppler Ultrasonography to Prevent Cerebrovascular Accident in Children with Sickle-Cell Disease

Transcranial Doppler Ultrasonography to Prevent Cerebrovascular Accident in Children with Sickle-Cell Disease

Transfusion‐transmitted malaria masquerading as sickle cell crisis with multisystem organ failure

Summer Camps for Children with Sickle Cell Disease

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