Blood Transfusion-Induced Immunomodulation

Landers, Dennis F.; Hill, Gary E.; Wong, K. C.; Fox, Ira J.

doi:10.1213/00000539-199601000-00035

Cited by 75 publications

(89 citation statements)

References 156 publications

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“…Given the likelihood of a multifactorial etiology, the association of transfusions or the underlying condition that necessitated transfusion to NHL risk is not clear. Interestingly, improved renal graft survival has been demonstrated with pre-transplant transfusions (Opelz et al, 1973), suggesting an immunosuppressive effect subsequent to transfusion that is measurable for extended time periods (Landers et al, 1996;Klein, 1999). The immunomodulatory effects of transfusions are proposed to induce a shift in endogenous cytokine secretion and a downregulation of T-cell activity while promoting a Th2 humoral response (Kirkley et al, 1995).…”

Section: Blood Transfusionsmentioning

confidence: 99%

The epidemiology of non-Hodgkin's lymphoma

2004

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The incidence of non-Hodgkin's lymphoma (NHL) has doubled over the past two decades in the US and most other westernized countries. While improved cancer reporting, changes in lymphoma classification, and increases in AIDS-associated lymphomas have contributed to the startling escalation of disease incidence, these factors are estimated to account for only about 50% of the increase in observed incidence. The elucidation of etiologic factors and their mechanistic role in the pathogenesis of this malignancy are critical to advancements in disease prevention and treatment. Current evidence suggests that factors/conditions that precipitate either chronic antigenic stimulation or immunosuppression may provide a preferential milieu for development of NHL. High rates of lymphoma have been observed among individuals with autoimmune disease, organ transplants, and primary or acquired immunodeficiencies. Ultraviolet radiation, previously demonstrated to have an immunosuppressive effect, has also been suggested as a possible risk factor for NHL. Several pathogens have been linked to the risk of lymphoma, including Epstein-Barr virus, human immunodeficiency virus, human T-cell lymphotropic virus-1, Helicobacter pylori, hepatitis C, and simian virus 40. Whether these microbes are responsible for specific genetic mutations that initiate tumor growth, antigenic stimulation leading to B-cell proliferation, and increased potential of random cell replication errors, or immunosuppression, which thereby promotes tumor growth, has not been clearly delineated. Other exogenous factors which have been implicated in lymphomagenesis are chemicals and agricultural exposures, hair dyes, and blood transfusions. We must build on our current knowledge regarding the etiology of NHL in order that prevention, treatment, and ultimately, cure of this malignancy becomes a reality.

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Section: Blood Transfusionsmentioning

confidence: 99%

The epidemiology of non-Hodgkin's lymphoma

2004

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“…A large body of literature exists showing a relationship between the infusion of red cells in transfusion and early postoperative increased rates of infection. [117][118][119][120] Such infections manifest as wound infections, higher pneumonia rates, dehiscence, and, in orthopedic joint replacements, osteomyelitis. In years past when early renal transplantation was being developed, it was the practice of those performing renal transplants to give every patient a transfusion because they were aware of the immunosuppressive effects of blood.…”

Section: Immunological Risksmentioning

confidence: 99%

Blood Tranfusion in Critically Ill Patients: State of the Art

Hajjar¹,

Jo²,

Santos³

et al. 2007

Clinics

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“…[23][24][25][26] Transfusions of blood and blood products can produce similar immunosuppressive effects. 27 Thus, chronic immune dysregulation from these exposures could increase risk of HD via poor immunologic control of infection with viruses, known or novel, having the potential to contribute to the development of HD. The Los Angeles cluster is consistent with the effects of reactivated EBV infection, as the high proportion of patients with the mixed cellularity subtype is a feature of EBV-positive HD.…”

Section: Dear Sirmentioning

confidence: 99%