Blood vitamin concentrations during the acute-phase response

Louw, J. A.; Werbeck, Anka; Louw, M. E. J.; Kotze, T.; Cooper, Rosemary; Labadarios, Demetre

doi:10.1097/00003246-199207000-00007

Cited by 220 publications

(184 citation statements)

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“…Vir and Love (1978) reported that 18.6% of patients consumed less than 0.66 mg of vitamin B6 per day and only 21.6% of the patients had a vitamin B6 intake higher or equal to 1 mg. In an other study (Louw et al, 1992), 25 subjects who underwent uncomplicated orthopedic surgery had an average of 1.7 and 1.6 mg vitamin B6 intake for men and women, respectively, 3 days after surgery. Elderly patients in the study of Powers et al (1993) consumed about 0.5 -4 mg=day pyridoxine.…”

Section: Discussionmentioning

confidence: 90%

“…They (Vir & Love, 1978) suggested that a diet higher in vitamin B6 should be given to aged patients. Louw et al (1992) found PLP decreased to values below the respective normal range during the acute-phase response. However, little is known about the intake and nutritional status of vitamin B6 in critically ill patients who have more complicated clinical conditions.…”

Section: Introductionmentioning

confidence: 77%

“…Several studies (Potera et al, 1977;Vir & Love, 1978;Louw et al, 1992;Pfitzenmeyer et al, 1997) have reported lower vitamin B6 status in hospitalized patients. Potera et al (1977) reported that advanced breast cancer patients had significantly lower plasma PLP levels than healthy women of similar age.…”

Section: Introductionmentioning

confidence: 99%

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Vitamin B6 intakes and status of mechanically ventilated critically ill patients in Taiwan

Huang¹,

Ph²,

Chen³

et al. 2002

Eur J Clin Nutr

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Objective: To assess vitamin B6 intake and status of critically ill patients. The relationship between vitamin B6 status indicators and the severity of illness and outcome in these patients was also examined. Design: Prospective clinical study. Setting: The study was performed at the Taichung Veteran General Hospital, in the central part of Taiwan. Subjects: Ninety-four patients in the intensive care unit (ICU) entered the study and 46 patients successfully completed this study. Interventions: No intervention. Main outcome measures: Vitamin B6 intake was recorded for 14 days. Vitamin B6 status was assessed by direct measures (plasma pyridoxal 5 0 -phosphate (PLP), pyridoxal (PL), and urinary 4-pyridoxic acid (4-PA)) and indirect measures (erythrocyte alanine (EALT-AC) and aspartate (EAST-AC) aminotransaminase activity coefficient). The severity of illness (APACHE II score), the length of ventilation dependency, and the length of ICU and hospital stay were recorded. Results: Patients had an adequate mean vitamin B6 intake (16.26 AE 19.39 mg) during the 14 day study. Mean vitamin B6 intake was significantly higher on day 14 than on day 1 (P < 0.001). However, plasma PLP and PL concentrations significantly decreased at the 14th day after admission (P < 0.05). Erythrocyte alanine aminotransaminase activity coefficient and EAST-AC did not change significantly. Urinary 4-PA significantly increased at the 14th day (P < 0.001). No significant relationships were found between APACHE II scores and clinical outcomes (the length of ICU and hospital stay, the length of ventilation dependency) of patients, vitamin B6 intake or status indicators. Conclusions: Critically ill patients received nutritional support in the ICU, and had sufficient mean vitamin B6 intake and adequate vitamin B6 status. Therefore, the severity of illness and the results should not be affected by vitamin B6 status. However, we have noted that plasma PLP and PL concentrations significantly decreased while vitamin B6 intake significantly increased on day 14. Critical clinical conditions and complex metabolism in the critically ill may account for the reduction of plasma PLP and PL. Since vitamin B6 deficiency causes profound effects on immune system function, dietary or supplemented vitamin B6 intake is suggested for hospitalized patients.

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Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 77%

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Vitamin B6 intakes and status of mechanically ventilated critically ill patients in Taiwan

Huang¹,

Ph²,

Chen³

et al. 2002

Eur J Clin Nutr

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“…In the study of Gray et al (2004), patients who underwent an elective knee arthroplasty had a significant increase in circulatory CRP concentrations and there was a significant fall in plasma PLP concentration but red cell PLP remained stable. This may be that critically ill patients were under severe stress during the systemic inflammatory response, which may have increased the turnover and utilization of plasma PLP, decreased hepatic PLP reserves (Louw et al, 1992), or redistributed PLP from plasma to erythrocyte (Talwar et al, 2003a;Gray et al, 2004;Quasim et al, 2005). Quasim et al (2005), therefore, suggested that direct measurements of red cell PLP are more responsive to supplementation than plasma measurements in the critically ill patients.…”

Section: Discussionmentioning

confidence: 99%

“…Critically ill patients were under severe stress, inflammation, and clinical conditions, which may increase the utilization and metabolic turnover of plasma PLP or even cause the redistribution of PLP from plasma to erythrocyte (Louw et al, 1992;Talwar et al, 2003a;Huang et al, 2005). It thus would be interesting to know whether a high dose of vitamin B 6 supplement would increase the immune response of critically ill patients.…”

Section: Introductionmentioning

confidence: 99%

Vitamin B6 supplementation increases immune responses in critically ill patients

Cheng

Chang²,

Lee

et al. 2006

Eur J Clin Nutr

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Relationship Between Systemic Markers of Inflammation and Serum β-Carotene Levels

Erlinger¹,

et al. 2001

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The strong and inverse association of serum beta-carotene level with C-reactive protein level and white blood cell count suggests that the relationship between serum beta-carotene concentration and disease risk might be confounded by inflammation. More broadly, for beta-carotene and likely other nutrients, it seems unwise to interpret biomarker data as prima facie evidence of dietary intake without a more complete understanding of the physiologic processes that affect nutrient levels.

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Blood vitamin concentrations during the acute-phase response

Cited by 220 publications

References 0 publications

Vitamin B6 intakes and status of mechanically ventilated critically ill patients in Taiwan

Vitamin B6 intakes and status of mechanically ventilated critically ill patients in Taiwan

Vitamin B6 supplementation increases immune responses in critically ill patients

Relationship Between Systemic Markers of Inflammation and Serum β-Carotene Levels

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