Blood Volume Regulation

Eb, Reeve; Th, Allen; Je, Roberts

doi:10.1146/annurev.ph.22.030160.002025

Cited by 9 publications

(2 citation statements)

References 100 publications

(129 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When a known quantity of dye ( N ) is injected into the blood stream, after an interval required for complete mixing, the quantity of dye ( n ) in 1 ml of withdrawn blood sample is analyzed. According to the relationship V = N / n , the plasma volume ( V ) can be calculated [ 36 ]. Then the total blood volume can be correctly calculated from the plasma volume according to the value of the hematocrit.…”

Section: Applications Derived From Albumin-binding Characteristic mentioning

confidence: 99%

“…To date, quantitation of EB dye can be optimized in limited tissue samples as much as 30 μ l [ 43 ]. However, since radioisotopic method to measure plasma volume was first introduced by Gibson and his coworkers in 1946, it has gradually replaced the EB dye dilution method [ 36 , 44 ]. Compared with the dye method (which occasionally overestimates the plasma volume), 131 I-labeled protein has been confirmed as an accurate measurement of plasma volume in both dogs and human subjects [ 45 ].…”

Section: Applications Derived From Albumin-binding Characteristic mentioning

confidence: 99%

See 1 more Smart Citation

Evans Blue Dye: A Revisit of Its Applications in Biomedicine

Yao

Xue

et al. 2018

Contrast Media & Molecular Imaging

124

View full text Add to dashboard Cite

Evans blue (EB) dye has owned a long history as a biological dye and diagnostic agent since its first staining application by Herbert McLean Evans in 1914. Due to its high water solubility and slow excretion, as well as its tight binding to serum albumin, EB has been widely used in biomedicine, including its use in estimating blood volume and vascular permeability, detecting lymph nodes, and localizing the tumor lesions. Recently, a series of EB derivatives have been labeled with PET isotopes and can be used as theranostics with a broad potential due to their improved half-life in the blood and reduced release. Some of EB derivatives have even been used in translational applications in clinics. In addition, a novel necrosis-avid feature of EB has recently been reported in some preclinical animal studies. Given all these interesting and important advances in EB study, a comprehensive revisiting of EB has been made in its biomedical applications in the review.

show abstract

Section: Applications Derived From Albumin-binding Characteristic mentioning

confidence: 99%