Blueberry anthocyanins-enriched extracts attenuate the cyclophosphamide-induced lung toxicity

D, Tan; Liu, Yunen; Shi, Lin; Li, Bin; Liu, Ling; Bai, Bing; Meng, Xianjun; Hou, Mingxiao; Liu, Xiaoxu; Sheng, Lei; Luo, Xinyue

doi:10.1016/j.cbi.2014.10.002

Cited by 14 publications

(12 citation statements)

References 47 publications

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“…AFNC enhanced these levels in the serum or spleen of CP-induced immunosuppressed mice model, indicating AFNC ameliorates the CP-induced immunosuppression. In addition, previous studies also demonstrated that blueberry extract, which is rich in anthocyanins, was effective against CP-induced cardiac injury and lung damage (Liu et al, 2015;Tan et al, 2014).…”

Section: Discussionmentioning

confidence: 93%

The immune‐enhancing effect of anthocyanin‐fucoidan nanocomplex in RAW264.7 macrophages and cyclophosphamide‐induced immunosuppressed mice

et al. 2021

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Aronia, a healthy fruit well known as black chokeberry, has health-promoting effects on hypertension, oxidative stress, and diabetes. Despite many reports of bioactivities of aronia, there is little scientific research on the potential for immune-enhancement.So, anthocyanin-fucoidan nanocomplex (AFNC, a nanocomplex of aronia extract and fucoidan) has been developed to improve immune-enhancement. This study aimed to identify immunomodulatory effects and underlying mechanisms of AFNC using RAW264.7 macrophages and cyclophosphamide-induced immunosuppressed mice.As a result, AFNC-treated RAW264.7 macrophages elevated the production of IL-2, IL-6, tumor necrosis factor (TNF)-α, and nitric oxide (NO). AFNC-enhanced inducible NO synthase expression via nuclear factor-κB signaling pathways. AFNC dosedependently increased levels of IL-2, IL-6, TNF-α, IL-10, IL-12, interferon-γ, or IL-4 in the serum and spleen of immunosuppressed mice. Taken together, AFNC encourages the immune-enhancing activity through immunostimulatory cytokine production by activation of macrophage. Therefore, these results suggest that AFNC is useful for immunodeficiency-related disorders. Practical applicationsIn these days of prevalence of infectious diseases, individual immunity is very important. AFNC has the immune-enhancing effects through immunostimulatory cytokine production by activation of macrophage. Therefore, AFNC could be widely applied to ameliorate a variety of diseases caused by immunosuppression such as infectious diseases.

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Section: Discussionmentioning

confidence: 93%

The immune‐enhancing effect of anthocyanin‐fucoidan nanocomplex in RAW264.7 macrophages and cyclophosphamide‐induced immunosuppressed mice

et al. 2021

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“…ALI is one of the serious adverse effects of the antineoplastic agent CP (Saghir et al, 2020; Suddek et al, 2013) with oxidative stress representing a major culprit behind tissue injury (Tan et al, 2014). This study explored the protective efficacy of the NADPH oxidase inhibitor AV on CP‐induced ALI in rats, focusing on the possible role of PI3K/Akt/mTOR and Nrf2 signaling.…”

Section: Discussionmentioning

confidence: 99%

“…ALI is one of the serious adverse effects of the antineoplastic agent CP (Saghir et al, 2020;Suddek et al, 2013) with oxidative stress representing a major culprit behind tissue injury (Tan et al, 2014) and interalveolar blood vessels and inflammatory cell infiltrates. AV significantly prevented tissue injury and histological alterations, demonstrating its potent protective efficacy against ALI in CP-intoxicated rats.…”

Section: Discussionmentioning

confidence: 99%

“…Lung tissue injury is one of the abundant CP toxic effects, where endothelial damage, granular pneumocyte injury, necrosis, pulmonary edema, hemorrhage, and cellular inflammatory infiltration are common histological findings (Saghir et al, 2020; Suddek, Ashry, & Gameil, 2013). Although the mechanisms underlying CP‐mediated lung injury are incompletely clear, imbalance between the production of reactive oxygen species (ROS) and the activity of the antioxidant defense system is implicated (Tan et al, 2014). Acrolein, a toxic metabolite of CP, is responsible for inducing cytotoxicity through the massive production of ROS (Moghe et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

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Acetovanillone prevents cyclophosphamide‐induced acute lung injury by modulating PI3K/Akt/mTOR and Nrf2 signaling in rats

El-Ghafar

Hassanein

Sayed

et al. 2021

Phytotherapy Research

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Cyclophosphamide (CP) is a medication used as an anticancer drug and to suppress the immune system. However, its clinical applications are restricted because of the toxic and adverse side effects. The present study investigated the protective effect of acetovanillone (AV), a natural NADPH oxidase inhibitor, against acute lung injury (ALI) induced by CP. Rats were administered AV (100 mg/kg) for 10 days and a single injection of CP (200 mg/kg) at day 7. At the end of the experiment, the animals were sacrificed, and lung samples were collected for analyses. CP caused ALI manifested by the histopathological alterations. Lipid peroxidation and NADPH oxidase activity were increased, whereas GSH and antioxidant enzymes were decreased in the lung of CP‐intoxicated rats. Oral administration of AV prevented CP‐induced lung injury and oxidative stress and enhanced antioxidant defenses. AV downregulated Keap1 and upregulated Nrf2, GCLC, HO‐1, and SOD3 mRNA. In addition, AV boosted the expression of PI3K, Akt, mTOR, and cytoglobin. In vitro, AV showed a synergistic anticancer effect when combined with CP. In conclusion, AV protected against CP‐induced ALI by attenuating oxidative stress and boosting Nrf2/HO‐1 and PI3K/Akt/mTOR signaling. Therefore, AV might represent a promising adjuvant to prevent lung injury in patients receiving CP.

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“…Blueberry fruits have been the focus of much recent attention due to numerous reports of their positive effects on human health. These benefits are generally attributed to high levels of flavonoids, AsA, and mineral composition (Prior, Lazarus, Cao, Muccitelli, & Hammerstone, 2001;Rasmussen, Frederiksen, Struntze Krogholm, & Poulsen, 2005;Tan et al, 2014;Taverniti et al, 2014). However, compared with the considerable research focused on the flavonoid metabolism of blueberries, little information is currently available on the mechanism controlling AsA levels in blueberries to date.…”

Section: Introductionmentioning

confidence: 99%

Higher transcription levels in ascorbic acid biosynthetic and recycling genes were associated with higher ascorbic acid accumulation in blueberry

Liu

Wang

et al. 2015

Food Chemistry

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Blueberry anthocyanins-enriched extracts attenuate the cyclophosphamide-induced lung toxicity

Cited by 14 publications

References 47 publications

The immune‐enhancing effect of anthocyanin‐fucoidan nanocomplex in RAW264.7 macrophages and cyclophosphamide‐induced immunosuppressed mice

The immune‐enhancing effect of anthocyanin‐fucoidan nanocomplex in RAW264.7 macrophages and cyclophosphamide‐induced immunosuppressed mice

Acetovanillone prevents cyclophosphamide‐induced acute lung injury by modulating PI3K/Akt/mTOR and Nrf2 signaling in rats

Higher transcription levels in ascorbic acid biosynthetic and recycling genes were associated with higher ascorbic acid accumulation in blueberry

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