Blueprints from plane to space: outlook of next‐generation three‐dimensional histopathology

Abstract

Here, we summarize the literature relevant to recent advances in three‐dimensional (3D) histopathology in relation to clinical oncology, highlighting serial sectioning, tissue clearing, light‐sheet microscopy, and digital image analysis with artificial intelligence. We look forward to a future where 3D histopathology expands our understanding of human pathophysiology and improves patient care through cross‐disciplinary collaboration and innovation.